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Comparison of perfused volume segmentation between cone-beam CT and 99mTc-MAA SPECT/CT for treatment dosimetry before selective internal radiation therapy using 90Y-glass microspheres
hal.structure.identifier | CIC Bordeaux | |
hal.structure.identifier | Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux] | |
dc.contributor.author | MARTIN, M. | |
hal.structure.identifier | Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] [CHUV] | |
dc.contributor.author | HOCQUELET, A. | |
hal.structure.identifier | CIC Bordeaux | |
hal.structure.identifier | Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux] | |
dc.contributor.author | DEBORDEAUX, F. | |
hal.structure.identifier | CIC Bordeaux | |
hal.structure.identifier | Bioingénierie tissulaire [BIOTIS] | |
hal.structure.identifier | Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux] | |
dc.contributor.author | BORDENAVE, L. | |
hal.structure.identifier | Hôpital Haut-Lévêque [CHU Bordeaux] | |
dc.contributor.author | BLANC, J.-F. | |
hal.structure.identifier | CIC Bordeaux | |
hal.structure.identifier | Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux] | |
dc.contributor.author | PAPADOPOULOS, P. | |
hal.structure.identifier | CIC Bordeaux | |
hal.structure.identifier | Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux] | |
dc.contributor.author | LAPUYADE, B. | |
hal.structure.identifier | CIC Bordeaux | |
hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
hal.structure.identifier | Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux] | |
dc.contributor.author | TRILLAUD, H. | |
hal.structure.identifier | CIC Bordeaux | |
hal.structure.identifier | Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux] | |
dc.contributor.author | PINAQUY, J.-B. | |
dc.date.accessioned | 2024-04-04T02:36:48Z | |
dc.date.available | 2024-04-04T02:36:48Z | |
dc.date.issued | 2021-01-31 | |
dc.identifier.issn | 2211-5684 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/190749 | |
dc.description.abstractEn | Purpose: To compare the reliability and accuracy of the pre-treatment dosimetry predictions using cone-beam computed tomography (CBCT) versus 99mTc-labeled macroaggregated albumin (MAA) SPECT/CT for perfused volume segmentation in patients with hepatocellular carcinoma treated by selective internal radiation therapy (SIRT) using 90Y-glass microspheres.Materials and methods: Fifteen patients (8 men, 7 women) with a mean age of 68.3±10.5 (SD) years (range: 47-82 years) who underwent a total of 17 SIRT procedures using 90Y-glass microspheres for unresectable hepatocellular carcinoma were retrospectively included. Pre-treatment dosimetry data were calculated from 99mTc-MAA SPECT/CT using either CBCT or 99mTc-MAA SPECT/CT to segment the perfused volumes. Post-treatment dosimetry data were calculated using 90Y imaging (SPECT/CT or PET/CT). The whole liver, non-tumoral liver, and tumor volumes were segmented on CT or MRI data. The mean absorbed doses of the tumor (DT), non-tumoral liver, perfused liver (DPL) and perfused non-tumoral liver were calculated. Intra- and interobserver reliabilities were investigated by calculating Lin's concordant correlation coefficients (ρc values). The differences (biases) between pre- and post-treatment dosimetry data were assessed using the modified Bland-Altman method (for non-normally distributed variables), and systematic bias was evaluated using Passing-Bablok regression.Results: The intra- and interobserver reliabilities were good-to-excellent (ρc: 0.80-0.99) for all measures using both methods. Compared with 90Y imaging, the median differences were 5.8Gy (IQR: -12.7; 16.1) and 5.6Gy (IQR: -13.6; 10.2) for DPL-CBCT and DPL-99mTc-MAA SPECT/CT, respectively. The median differences were 1.6Gy (IQR: -29; 7.53) and 9.8Gy (IQR: -28.4; 19.9) for DT-CBCT and DT-99mTc-MAA SPECT/CT respectively. Passing-Bablok regression analysis showed that both CBCT and 99mTc-MAA SPECT/CT had proportional biases and thus tendencies to overestimate DT and DPL at higher post-treatment doses.Conclusion: CBCT may be a reliable segmentation method, but it does not significantly increase the accuracy of dose prediction compared with that of 99mTc-MAA SPECT/CT. At higher doses both methods tend to overestimate the doses to tumors and perfused livers. | |
dc.language.iso | en | |
dc.publisher | Elsevier | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/ | |
dc.subject.en | Brachytherapy | |
dc.subject.en | Carcinoma | |
dc.subject.en | hepatocellular | |
dc.subject.en | Cone-beam CT | |
dc.subject.en | Radiation dosimetry | |
dc.subject.en | SPECT CT | |
dc.subject.en | Yttrium-90 | |
dc.title.en | Comparison of perfused volume segmentation between cone-beam CT and 99mTc-MAA SPECT/CT for treatment dosimetry before selective internal radiation therapy using 90Y-glass microspheres | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1016/j.diii.2020.09.003 | |
dc.subject.hal | Sciences du Vivant [q-bio] | |
bordeaux.journal | Diagnostic and Interventional Imaging | |
bordeaux.page | 45 - 52 | |
bordeaux.volume | 102 | |
bordeaux.hal.laboratories | Institut de Mathématiques de Bordeaux (IMB) - UMR 5251 | * |
bordeaux.institution | Université de Bordeaux | |
bordeaux.institution | Bordeaux INP | |
bordeaux.institution | CNRS | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-03493594 | |
hal.version | 1 | |
hal.popular | non | |
hal.audience | Internationale | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-03493594v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Diagnostic%20and%20Interventional%20Imaging&rft.date=2021-01-31&rft.volume=102&rft.spage=45%20-%2052&rft.epage=45%20-%2052&rft.eissn=2211-5684&rft.issn=2211-5684&rft.au=MARTIN,%20M.&HOCQUELET,%20A.&DEBORDEAUX,%20F.&BORDENAVE,%20L.&BLANC,%20J.-F.&rft.genre=article |
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