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Inter-individual differences in cell composition across the ventricular wall may explain variability in ECG response to serum potassium and calcium variations

hal.structure.identifierAragón Institute of Engineering Research [Zaragoza] [I3A]
hal.structure.identifierBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN]
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorBUKHARI, Hassaan
hal.structure.identifierAragón Institute of Engineering Research [Zaragoza] [I3A]
hal.structure.identifierBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN]
dc.contributor.authorSÁNCHEZ, Carlos
hal.structure.identifierAragón Institute of Engineering Research [Zaragoza] [I3A]
hal.structure.identifierBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN]
dc.contributor.authorLAGUNA, Pablo
hal.structure.identifierIHU-LIRYC
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorPOTSE, Mark
hal.structure.identifierAragón Institute of Engineering Research [Zaragoza] [I3A]
hal.structure.identifierCentro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina [CIBER-BBN]
dc.contributor.authorPUEYO, Esther
dc.date.accessioned2024-04-04T02:36:09Z
dc.date.available2024-04-04T02:36:09Z
dc.date.conference2022-09-05
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/190704
dc.description.abstractEnNon-invasive monitoring of serum potassium ([K + ]) and calcium ([Ca 2+ ]) concentration can help to prevent arrhythmia in kidney patients. Current electrocardiogram (ECG) markers, including the T wave width (T w) and its time-warped temporal morphological variability (d U w), correlate significantly with [K + ] and [Ca 2+ ] but these relations vary strongly between patients. We hypothesized that inter-individual differences in cell type distribution across the ventricular wall can explain this variability. We computed T w and d U w in simulated ECGs from a human heart-torso model at different proportions of endo-, mid-, and epicardial cells, while varying [K + ] (3 to 6.2 mM) and [Ca 2+ ] (1.4 to 3.2 mM). Electrical activity was simulated with a reaction-diffusion model with modified Ten Tusscher-Panfilov dynamics. Results were compared to data from 29 patients. T w and d U w correlated strongly with [K + ] (absolute median Pearson coefficient r = 0.70 to 0.93) and [Ca 2+ ] (r = 0.69 to 0.86) in simulations and in patients. Different cell type distributions reproduced inter-patient variability, with the same sign and magnitude of r. In conclusion, the inter-patient variability in the relation between serum electrolytes and their ECG markers can indeed be explained by inter-individual differences in cell type distribution across the ventricular wall.
dc.description.sponsorshipL'Institut de Rythmologie et modélisation Cardiaque - ANR-10-IAHU-0004
dc.language.isoen
dc.title.enInter-individual differences in cell composition across the ventricular wall may explain variability in ECG response to serum potassium and calcium variations
dc.typeCommunication dans un congrès
dc.subject.halInformatique [cs]
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
dc.description.sponsorshipEuropePersonalised In-Silico Cardiology
dc.description.sponsorshipEuropeIs your heart aging well? A systems biology approach to characterize cardiac aging from the cell to the body surface
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.conference.titleComputing in Cardiology 2022
bordeaux.countryFI
bordeaux.conference.cityTampere
bordeaux.peerReviewedoui
hal.identifierhal-03936957
hal.version1
hal.invitednon
hal.proceedingsnon
hal.conference.end2022-09-07
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-03936957v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.au=BUKHARI,%20Hassaan&S%C3%81NCHEZ,%20Carlos&LAGUNA,%20Pablo&POTSE,%20Mark&PUEYO,%20Esther&rft.genre=unknown


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