Inter-individual differences in cell composition across the ventricular wall may explain variability in ECG response to serum potassium and calcium variations
hal.structure.identifier | Aragón Institute of Engineering Research [Zaragoza] [I3A] | |
hal.structure.identifier | Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN] | |
hal.structure.identifier | Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN] | |
hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
dc.contributor.author | BUKHARI, Hassaan | |
hal.structure.identifier | Aragón Institute of Engineering Research [Zaragoza] [I3A] | |
hal.structure.identifier | Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN] | |
dc.contributor.author | SÁNCHEZ, Carlos | |
hal.structure.identifier | Aragón Institute of Engineering Research [Zaragoza] [I3A] | |
hal.structure.identifier | Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN] | |
dc.contributor.author | LAGUNA, Pablo | |
hal.structure.identifier | IHU-LIRYC | |
hal.structure.identifier | Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN] | |
hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
dc.contributor.author | POTSE, Mark | |
hal.structure.identifier | Aragón Institute of Engineering Research [Zaragoza] [I3A] | |
hal.structure.identifier | Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina [CIBER-BBN] | |
dc.contributor.author | PUEYO, Esther | |
dc.date.accessioned | 2024-04-04T02:36:09Z | |
dc.date.available | 2024-04-04T02:36:09Z | |
dc.date.conference | 2022-09-05 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/190704 | |
dc.description.abstractEn | Non-invasive monitoring of serum potassium ([K + ]) and calcium ([Ca 2+ ]) concentration can help to prevent arrhythmia in kidney patients. Current electrocardiogram (ECG) markers, including the T wave width (T w) and its time-warped temporal morphological variability (d U w), correlate significantly with [K + ] and [Ca 2+ ] but these relations vary strongly between patients. We hypothesized that inter-individual differences in cell type distribution across the ventricular wall can explain this variability. We computed T w and d U w in simulated ECGs from a human heart-torso model at different proportions of endo-, mid-, and epicardial cells, while varying [K + ] (3 to 6.2 mM) and [Ca 2+ ] (1.4 to 3.2 mM). Electrical activity was simulated with a reaction-diffusion model with modified Ten Tusscher-Panfilov dynamics. Results were compared to data from 29 patients. T w and d U w correlated strongly with [K + ] (absolute median Pearson coefficient r = 0.70 to 0.93) and [Ca 2+ ] (r = 0.69 to 0.86) in simulations and in patients. Different cell type distributions reproduced inter-patient variability, with the same sign and magnitude of r. In conclusion, the inter-patient variability in the relation between serum electrolytes and their ECG markers can indeed be explained by inter-individual differences in cell type distribution across the ventricular wall. | |
dc.description.sponsorship | L'Institut de Rythmologie et modélisation Cardiaque - ANR-10-IAHU-0004 | |
dc.language.iso | en | |
dc.title.en | Inter-individual differences in cell composition across the ventricular wall may explain variability in ECG response to serum potassium and calcium variations | |
dc.type | Communication dans un congrès | |
dc.subject.hal | Informatique [cs] | |
dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire | |
dc.description.sponsorshipEurope | Personalised In-Silico Cardiology | |
dc.description.sponsorshipEurope | Is your heart aging well? A systems biology approach to characterize cardiac aging from the cell to the body surface | |
bordeaux.hal.laboratories | Institut de Mathématiques de Bordeaux (IMB) - UMR 5251 | * |
bordeaux.institution | Université de Bordeaux | |
bordeaux.institution | Bordeaux INP | |
bordeaux.institution | CNRS | |
bordeaux.conference.title | Computing in Cardiology 2022 | |
bordeaux.country | FI | |
bordeaux.conference.city | Tampere | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-03936957 | |
hal.version | 1 | |
hal.invited | non | |
hal.proceedings | non | |
hal.conference.end | 2022-09-07 | |
hal.popular | non | |
hal.audience | Internationale | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-03936957v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.au=BUKHARI,%20Hassaan&S%C3%81NCHEZ,%20Carlos&LAGUNA,%20Pablo&POTSE,%20Mark&PUEYO,%20Esther&rft.genre=unknown |
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