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Urine Protein/Creatinine Ratio in Thrombotic Microangiopathies: A Simple Test to Facilitate Thrombotic Thrombocytopenic Purpura and Hemolytic and Uremic Syndrome Diagnosis

hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorBURGUET, Laure
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorTATON, Benjamin
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorPREZELIN-REYDIT, Mathilde
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorRUBIN, Sebastien
dc.contributor.authorPICARD, Walter
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorGRUSON, Didier
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
hal.structure.identifierCHU Saint-Antoine [AP-HP]
dc.contributor.authorRYMAN, Anne
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
hal.structure.identifierCHU Saint-Antoine [AP-HP]
dc.contributor.authorCONTIN BORDES, Cecile
hal.structure.identifierCHU Saint-Antoine [AP-HP]
dc.contributor.authorCOPPO, Paul
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorCOMBE, Christian
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
hal.structure.identifierCHU Saint-Antoine [AP-HP]
dc.contributor.authorDELMAS, Yahsou
dc.date.accessioned2024-04-04T02:34:36Z
dc.date.available2024-04-04T02:34:36Z
dc.date.issued2022-01
dc.identifier.issn2077-0383
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/190567
dc.description.abstractEnBackground: Early diagnosis of thrombotic thrombocytopenic purpura (TTP) versus hemolytic and uremic syndrome (HUS) is critical for the prompt initiation of specific therapies.Objective: To evaluate the diagnostic performance of the proteinuria/creatininuria ratio (PU/CU) for TTP versus HUS. Patients/Methods: In a retrospective study, in association with the “French Score” (FS) (platelets < 30 G/L and serum creatinine level < 200 µmol/L), we assessed PU/CU for the diagnosis of TTP in patients above the age of 15 with thrombotic microangiopathy (TMA). Patients with a history of kidney disease or with on-going cancer, allograft or pregnancy were excluded from the analysis.Results: Between February 2011 and April 2019, we identified 124 TMA. Fifty-six TMA patients for whom PU/CU were available, including 35 TTP and 21 HUS cases, were considered. Using receiver–operating characteristic curves (ROC), those with a threshold of 1.5 g/g for the PU/CU had a 77% sensitivity (95% CI (63, 94)) and a 90% specificity (95% CI (71, 100)) for TTP diagnosis compared with those having an 80% sensitivity (95% CI (66, 92)) and a 90% specificity (95% CI (76, 100) with a FS of 2. In comparison, a composite score, defined as a FS of 2 or a PU/CU ≤ 1.5 g/g, improved sensitivity to 99.6% (95% CI (93, 100)) for TTP diagnosis and enabled us to reclassify seven false-negative TTP patients.Conclusions: The addition of urinary PU/CU upon admission of patients with TMA is a fast and readily available test that can aid in the differential diagnosis of TTP versus HUS alongside traditional scoring.
dc.language.isoen
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.endiagnosis
dc.subject.endifferential
dc.subject.enhemolytic-uremic syndrome
dc.subject.enproteinuria
dc.subject.enpurpura
dc.subject.enthrombotic microangiopathies
dc.subject.enthrombotic thrombocytopenic
dc.title.enUrine Protein/Creatinine Ratio in Thrombotic Microangiopathies: A Simple Test to Facilitate Thrombotic Thrombocytopenic Purpura and Hemolytic and Uremic Syndrome Diagnosis
dc.typeArticle de revue
dc.identifier.doi10.3390/jcm11030648
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Hématologie
bordeaux.journalJournal of Clinical Medicine
bordeaux.page648
bordeaux.volume11
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue3
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-04057640
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04057640v1
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Journal%20of%20Clinical%20Medicine&amp;rft.date=2022-01&amp;rft.volume=11&amp;rft.issue=3&amp;rft.spage=648&amp;rft.epage=648&amp;rft.eissn=2077-0383&amp;rft.issn=2077-0383&amp;rft.au=BURGUET,%20Laure&amp;TATON,%20Benjamin&amp;PREZELIN-REYDIT,%20Mathilde&amp;RUBIN,%20Sebastien&amp;PICARD,%20Walter&amp;rft.genre=article


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