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Inter-operator segmentation variability induces high premature ventricular contractions localization uncertainty at the heart base

hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierInstitut de rythmologie et modélisation cardiaque [Pessac] [IHU Liryc]
dc.contributor.authorGASSA, Narimane
hal.structure.identifierScientific Computing and Imaging Institute [SCI Institute]
dc.contributor.authorTATE, Jess
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorBOONSTRA, Machteld
hal.structure.identifierInstitute of Measurement Science [IMS]
dc.contributor.authorONDRUSOVA, Beata
hal.structure.identifierInstitute of Measurement Science [IMS]
dc.contributor.authorSVEHLIKOVA, Jana
hal.structure.identifierUniversity of Utah
dc.contributor.authorMACLEOD, Rob
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorZEMZEMI, Nejib
dc.date.accessioned2024-04-04T02:34:02Z
dc.date.available2024-04-04T02:34:02Z
dc.date.issued2023-05
dc.date.conference2023-05-19
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/190525
dc.description.abstractEnBackgroundElectrocardiographic imaging (ECGI) is a promising tool for the treatment and diagnosis of cardiac arrhythmias. ECGI estimates non-invasively the electrical activity of the heart using body surface potentials (BSPs) obtained at the body surface in combination with a specific CT/MRI based anatomical models and defined electrode positions. In order to solve the ECGI inverse problem the first step to be considered is indeed the image segmentation and mesh generation.ObjectiveOur main purpose is to evaluate the effect of the inter-operator segmentation variability on the PVC localization.MethodsEight different cardiac segmentations from the same single subject CT-scans were performed by researchers within the consortium for Electrocardiographic Imaging. For all generated meshes, eight ventricular stimulation protocols were used; left and right ventricular free walls (LV, RV), apex, left and right ventricular outflow tract (LVOT, RVOT), septum, and two locations at the left and right heart base (LVB, RVB). BSPs were generated using computational models. We designed two test cases: with and without segmentation uncertainty. In test A, no segmentation uncertainty is considered. In test B, we solve the inverse problem for the eight geometries starting from one single BSP generated with a reference heart geometry. For each test case and for each stimulation protocol we computed the inverse solution using the Method of Fundamental Solutions and assessed the Localization Error (LE) of the pacing sites. In order to quantify the effect of segmentation uncertainty we also computed the difference between LEs obtained in tests B and A.ResultsIn test A, the mean LEs for LV, RV, apex, LVOT, RVOT, septum, LVB and RVB pacings are 7, 7, 5, 12, 14, 18, 13, 15 mm, respectively. In test B, the mean LEs are 7, 7, 5, 17, 23, 17, 16, 23 mm, respectively. The average differences between LEs are 0, 0, -1,5, 8, -1, 3, 8 mm, respectively.ConclusionThis study shows that the effect of the segmentation uncertainty on the localization of PVC is more important for RVOT, LVOT, RVB and LVB. We believe that the high uncertainty is due to the variability of segmentations at the base of the heart. These findings suggest that uncertainty in cardiac segmentation can have a significant impact on ECGI and its interpretability in clinical applications; therefore, careful segmentation is strongly recommended, especially at the base of the heart.
dc.language.isoen
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.title.enInter-operator segmentation variability induces high premature ventricular contractions localization uncertainty at the heart base
dc.typeAutre communication scientifique (congrès sans actes - poster - séminaire...)
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale
dc.description.sponsorshipEuropePersonalized Therapies for Atrial Fibrillation. A Translational Approach
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.conference.titleHeart Rhythm 2023 - The Society's 44th annual meeting
bordeaux.countryUS
bordeaux.conference.cityNew Orleans (LA)
bordeaux.peerReviewedoui
hal.identifierhal-04124313
hal.version1
hal.invitednon
hal.proceedingsnon
hal.conference.end2023-05-21
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04124313v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2023-05&rft.au=GASSA,%20Narimane&TATE,%20Jess&BOONSTRA,%20Machteld&ONDRUSOVA,%20Beata&SVEHLIKOVA,%20Jana&rft.genre=conference


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