Afficher la notice abrégée

An individual-based model to explore the impact of psychological stress on immune infiltration into tumour spheroids

hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierModélisation Mathématique pour l'Oncologie [MONC]
dc.contributor.authorLESCHIERA, Emma
hal.structure.identifierUniversity of Brighton
dc.contributor.authorAL-HITY, Gheed
hal.structure.identifierUniversity of Brighton
dc.contributor.authorFLINT, Melanie S.
hal.structure.identifierUniversity of Sussex
dc.contributor.authorVENKATARAMAN, Chandrasekhar
hal.structure.identifierPolitecnico di Torino = Polytechnic of Turin [Polito]
dc.contributor.authorLORENZI, Tommaso
hal.structure.identifierLaboratoire Jacques-Louis Lions [LJLL (UMR_7598)]
dc.contributor.authorALMEIDA, Luis
hal.structure.identifierLaboratoire Jacques-Louis Lions [LJLL (UMR_7598)]
hal.structure.identifierMathematical Modeling in Biology [LCQB] [LCQB-MMB]
dc.contributor.authorAUDEBERT, Chloe
dc.date.accessioned2024-04-04T02:33:33Z
dc.date.available2024-04-04T02:33:33Z
dc.date.created2023-07-21
dc.date.issued2023-07-24
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/190492
dc.description.abstractEnIn recent in vitro experiments on co-culture between breast tumour spheroids and activated immune cells, it was observed that the introduction of the stress hormone cortisol resulted in a decreased immune cell infiltration into the spheroids. Moreover, the presence of cortisol deregulated the normal levels of the pro- and anti-inflammatory cytokines IFN-{\gamma} and IL-10. We present an individual-based model to explore the interaction dynamics between tumour and immune cells under psychological stress conditions. With our model, we explore the processes underlying the emergence of different levels of immune infiltration, with particular focus on the biological mechanisms regulated by IFN-{\gamma} and IL-10. The set-up of numerical simulations is defined to mimic the scenarios considered in the experimental study. Similarly to the experimental quantitative analysis, we compute a score that quantifies the level of immune cell infiltration into the tumour. The results of numerical simulations indicate that the motility of immune cells, their capability to infiltrate through tumour cells, their growth rate and the interplay between these cell parameters can affect the level of immune cell infiltration in different ways. Ultimately, numerical simulations of this model support a deeper understanding of the impact of biological stress-induced mechanisms on immune infiltration.
dc.description.sponsorshipCenters of Hosting and International Mathematical Encounters - ANR-10-LABX-0059
dc.language.isoen
dc.subject.enNumerical simulations
dc.subject.enImmune infiltration
dc.subject.enPsychological stress
dc.subject.enIndividual- based models
dc.subject.enTumour-Immune interactions
dc.title.enAn individual-based model to explore the impact of psychological stress on immune infiltration into tumour spheroids
dc.typeDocument de travail - Pré-publication
dc.subject.halSciences du Vivant [q-bio]
dc.subject.halMathématiques [math]
dc.identifier.arxiv2307.12627
dc.description.sponsorshipEuropeAsymptotic approach to spatial and dynamical organizations
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
hal.identifierhal-04170128
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04170128v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2023-07-24&rft.au=LESCHIERA,%20Emma&AL-HITY,%20Gheed&FLINT,%20Melanie%20S.&VENKATARAMAN,%20Chandrasekhar&LORENZI,%20Tommaso&rft.genre=preprint


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée