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Non-Contrast-Enhanced Functional Lung MRI to Evaluate Treatment Response of Allergic Bronchopulmonary Aspergillosis in Patients With Cystic Fibrosis: A Pilot Study

hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
hal.structure.identifierLudwig Maximilian University [Munich] = Ludwig Maximilians Universität München [LMU]
dc.contributor.authorBENLALA, Ilyes
hal.structure.identifierLudwig Maximilian University [Munich] = Ludwig Maximilians Universität München [LMU]
dc.contributor.authorKLAAR, Rabea
hal.structure.identifierLudwig Maximilian University [Munich] = Ludwig Maximilians Universität München [LMU]
dc.contributor.authorGAASS, Thomas
hal.structure.identifierCHU Bordeaux
hal.structure.identifierCIC Bordeaux
dc.contributor.authorMACEY, Julie
hal.structure.identifierCHU Bordeaux
hal.structure.identifierCIC Bordeaux
dc.contributor.authorBUI, Stéphanie
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierModélisation Mathématique pour l'Oncologie [MONC]
dc.contributor.authorDENIS DE SENNEVILLE, Baudouin
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
hal.structure.identifierCIC Bordeaux
dc.contributor.authorBERGER, Patrick
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
hal.structure.identifierCIC Bordeaux
dc.contributor.authorLAURENT, François
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
hal.structure.identifierCIC Bordeaux
dc.contributor.authorDOURNES, Gael
hal.structure.identifierLudwig Maximilian University [Munich] = Ludwig Maximilians Universität München [LMU]
dc.contributor.authorDINKEL, Julien
dc.date2023-06
dc.date.accessioned2024-04-04T02:32:52Z
dc.date.available2024-04-04T02:32:52Z
dc.date.issued2023-06
dc.identifier.issn1053-1807
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/190422
dc.description.abstractEnBackground: Allergic bronchopulmonary aspergillosis (ABPA) in cystic fibrosis (CF) patients is associated with severe lung damage and requires specific therapeutic management. Repeated imaging is recommended to both diagnose and follow-up response to treatment of ABPA in CF. However, high risk of cumulative radiation exposure requires evaluation of free-radiation techniques in the follow-up of CF patients with ABPA.Purpose: To evaluate whether Fourier decomposition (FD) functional lung MRI can detect response to treatment of ABPA in CF patients.Study Type: Retrospective longitudinal.Population: Twelve patients (7M, median-age:14 years) with CF and ABPA with pre- and post-treatment MRI.Field Strength/Sequence: 2D-balanced-steady-state free-precession (bSSFP) sequence with FD at 1.5T.Assessment: Ventilation-weighted (V) and perfusion-weighted (Q) maps were obtained after FD processing of 2D-coronal bSSFP time-resolved images acquired before and 3–9 months after treatment. Defects extent was assessed on the functional maps using a qualitative semi-quantitative score (0 = absence/negligible, 1 = <50%, 2 = >50%). Mean and coefficient of variation (CV) of the ventilation signal-intensity (VSI) and the perfusion signal-intensity (QSI) were calculated. Measurements were performed independently by three readers and averaged. Inter-reader reproducibility of the measurements was assessed. Pulmonary function tests (PFTs) were performed within 1 week of both MRI studies as markers of the airflow-limitation severity.Statistical Tests: Comparisons of medians were performed using the paired Wilcoxon-test. Reproducibility was assessed using intraclass correlation coefficient (ICC). Correlations between MRI and PFT parameters were assessed using the Spearman-test (rho correlation-coefficient). A P-value <0.05 was considered as significant.Results: Defects extent on both V and Q maps showed a significant reduction after ABPA treatment (4.25 vs. 1.92 for V-defect-score and 5 vs. 2.75 for Q-defect-score). VSI_mean was significantly increased after treatment (280 vs. 167). Qualitative analyses reproducibility showed an ICC > 0.90, while the ICCs of the quantitative measurements was almost perfect (>0.99). Changes in VSI_cv and QSI_cv before and after treatment correlated inversely with changes of FEV1%p (rho = −0.68 for both).Data Conclusion: Non-contrast-enhanced FD lung MRI has potential to reproducibly assess response to treatment of ABPA in CF patients and correlates with PFT obstructive parameters.Evidence Level: 4Technical Efficacy: Stage 3
dc.language.isoen
dc.publisherWiley-Blackwell
dc.subject.enABPA
dc.subject.enCF
dc.subject.enventilation
dc.subject.enperfusion
dc.subject.enFourier decomposition
dc.title.enNon-Contrast-Enhanced Functional Lung MRI to Evaluate Treatment Response of Allergic Bronchopulmonary Aspergillosis in Patients With Cystic Fibrosis: A Pilot Study
dc.typeArticle de revue
dc.identifier.doi10.1002/jmri.28844
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale/Imagerie
dc.subject.halSciences du Vivant [q-bio]/Immunologie/Allergologie
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieuses
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Pneumologie et système respiratoire
bordeaux.journalJournal of Magnetic Resonance Imaging
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-04268654
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04268654v1
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