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Continuity of Mircoscopic Cardiac Conduction in a Computational Cell-by-Cell Model

hal.structure.identifierKarlsruhe Institute of Technology = Karlsruher Institut für Technologie [KIT]
dc.contributor.authorSTEYER, Joshua
hal.structure.identifierZuse Institute Berlin [ZIB]
dc.contributor.authorCHEGINI, Fatemeh
hal.structure.identifierIHU-LIRYC
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorPOTSE, Mark
hal.structure.identifierKarlsruhe Institute of Technology = Karlsruher Institut für Technologie [KIT]
dc.contributor.authorLOEWE, Axel
hal.structure.identifierZuse Institute Berlin [ZIB]
dc.contributor.authorWEISER, Martin
dc.date.accessioned2024-04-04T02:30:57Z
dc.date.available2024-04-04T02:30:57Z
dc.date.conference2023-10-01
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/190277
dc.description.abstractEnConduction velocity in cardiac tissue is a crucial electrophysiological parameter for arrhythmia vulnerability. Pathologically reduced conduction velocity facilitates arrhythmogenesis because such conduction velocities decrease the wavelength with which re-entry may occur. Computational studies on CV and how it changes regionally in models at spatial scales multiple times larger than actual cardiac cells exist. However, microscopic conduction within cells and between them have been studied less in simulations. In this work, we study the relation of microscopic conduction patterns and clinically observable macroscopic conduction using an extracellular-membrane-intracellular model which represents cardiac tissue with these subdomains at subcellular resolution. By considering cell arrangement and non-uniform gap junction distribution, it yields anisotropic excitation propagation. This novel kind of model can for example be used to understand how discontinuous conduction on the microscopic level affects fractionation of electrograms in healthy and fibrotic tissue. Along the membrane of a cell, we observed a continuously propagating activation wavefront. When transitioning from one cell to the neighbouring one, jumps in local activation times occurred, which led to lower global conduction velocities than locally within each cell.
dc.description.sponsorshipL'Institut de Rythmologie et modélisation Cardiaque - ANR-10-IAHU-0004
dc.language.isoen
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.title.enContinuity of Mircoscopic Cardiac Conduction in a Computational Cell-by-Cell Model
dc.typeCommunication dans un congrès
dc.identifier.doi10.22489/CinC.2023.385
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
dc.subject.halInformatique [cs]/Modélisation et simulation
dc.description.sponsorshipEuropeNumerical modeling of cardiac electrophysiology at the cellular scale
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.conference.titleCinC 2023 - 50th Computing in Cardiology Conference
bordeaux.countryUS
bordeaux.conference.cityAtlanta (GA)
bordeaux.peerReviewedoui
hal.identifierhal-04407818
hal.version1
hal.invitednon
hal.proceedingsoui
hal.conference.end2023-10-04
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04407818v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.au=STEYER,%20Joshua&CHEGINI,%20Fatemeh&POTSE,%20Mark&LOEWE,%20Axel&WEISER,%20Martin&rft.genre=unknown


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