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When should a trophically and vertically transmitted parasite manipulate its intermediate host? The case of Toxoplasma gondii.

hal.structure.identifierNational Institute for Mathematical and Biological Synthesis [NIMBioS]
dc.contributor.authorLÉLU, Maud
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorLANGLAIS, Michel
hal.structure.identifierCentre de Recherche et de Formation en Eco-éthologie [2C2A-CERFE]
dc.contributor.authorPOULLE, Marie-Lazarine
hal.structure.identifierBiodémographie évolutive [LBBE]
dc.contributor.authorGILOT-FROMONT, Emmanuelle
hal.structure.identifierCentre d’Ecologie Fonctionnelle et Evolutive [CEFE]
dc.contributor.authorGANDON, Sylvain
dc.date.accessioned2024-04-04T02:18:32Z
dc.date.available2024-04-04T02:18:32Z
dc.date.issued2013-08-22
dc.identifier.issn1744-9561
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/189323
dc.description.abstractEnParasites with complex life cycles are expected to manipulate the behaviour of their intermediate hosts (IHs), which increase their predation rate and facilitate the transmission to definitive hosts (DHs). This ability, however, is a double-edged sword when the parasite can also be transmitted vertically in the IH. In this situation, as the manipulation of the IH behaviour increases the IH death rate, it conflicts with vertical transmission, which requires healthy and reproducing IHs. The protozoan Toxoplasma gondii, a widespread pathogen, combines both trophic and vertical transmission strategies. Is parasite manipulation of host behaviour still adaptive in this situation? We model the evolution of the IH manipulation by T. gondii to study the conflict between these two routes of transmission under different epidemiological situations. Model outputs show that manipulation is particularly advantageous for virulent strains and in epidemic situations, and that different levels of manipulation may evolve depending on the sex of the IH and the transmission routes considered. These results may help to understand the variability of strain characteristics encountered for T. gondii and may extend to other trophically transmitted parasites.
dc.language.isoen
dc.publisherRoyal Society, The
dc.subject.meshAnimals
dc.subject.meshCats
dc.subject.meshModels, Biological
dc.subject.meshPopulation Dynamics
dc.subject.meshRats
dc.subject.meshToxoplasma
dc.subject.meshToxoplasmosis, Animal
dc.subject.meshVirulence
dc.subject.meshFemale
dc.subject.meshHost-Parasite Interactions
dc.subject.meshInfectious Disease Transmission, Vertical
dc.subject.meshLife Cycle Stages
dc.subject.meshMale
dc.title.enWhen should a trophically and vertically transmitted parasite manipulate its intermediate host? The case of Toxoplasma gondii.
dc.typeArticle de revue
dc.identifier.doi10.1098/rspb.2013.1143
dc.subject.halSciences du Vivant [q-bio]
bordeaux.journalBiology Letters
bordeaux.page20131143
bordeaux.volume280
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue1765
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-00972562
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00972562v1
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