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dc.rights.licenseopenen_US
dc.contributor.authorCHAMBORD, Jeremy
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorCHAUVEAU, Bertrand
hal.structure.identifierBoRdeaux Institute in onCology [Inserm U1312 - BRIC]
dc.contributor.authorDJABAROUTI, Sarah
dc.contributor.authorVIGNAUD, Jean
dc.contributor.authorTATON, Benjamin
dc.contributor.authorMOREAU, Karine
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorVISENTIN, Jonathan
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorMERVILLE, Pierre
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorXUEREB, Fabien
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorCOUZI, Lionel
dc.date.accessioned2024-03-11T15:29:32Z
dc.date.available2024-03-11T15:29:32Z
dc.date.issued2023-01-01
dc.identifier.issn1432-2277en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/188690
dc.description.abstractEnOur objective was to calculate an immunosuppressant possession ratio (IPR) to diagnose non-adherence at the time of antibody-mediated rejection (ABMR). IPR was defined as the ratio of number of pills collected at the pharmacy to the number of pills prescribed over a defined period. In a first cohort of 91 kidney transplant recipients (KTRs), those with an IPR 30% than patients with an IPR = 100% (66.7% vs. 29.4%, = 0.05). In a case-control study, 26 KTRs with ABMR had lower 6 months IPRs than 26 controls (76% vs. 99%, < 0.001). In KTRs with ABMR, non-adherence was more often diagnosed by a 6 months IPR < 90% than by clinical suspicion (73.1% vs 30.8%, = 0.02). In the multivariable analysis, only DSA and 6 months IPR < 90% were independently associated with ABMR, whereas clinical suspicion was not (odds ratio, 4.73; 95% CI, 1.17-21.88; = 0.03; and odds ratio, 6.34; 95% CI, 1.73-25.59; = 0.007, respectively). In summary, IPR < 90% is a quantifiable tool to measure immunosuppressant non-adherence. It is better associated with ABMR than clinical suspicion of non-adherence.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectarticle clinique
dc.subject.enHumans
dc.subject.enImmunosuppressive Agents
dc.subject.enCase-Control Studies
dc.subject.enPharmacists
dc.subject.enKidney Transplantation
dc.subject.enAntibodies
dc.subject.enGraft Rejection
dc.subject.enIsoantibodies
dc.title.enMeasurement of the Immunosuppressant Possession Ratio by Transplant Clinical Pharmacists Captures a Non-Adherence Associated With Antibody-Mediated Rejection.
dc.title.alternativeTranspl Inten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3389/ti.2023.11962en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
dc.identifier.pubmed38089004en_US
bordeaux.journalTransplant Internationalen_US
bordeaux.page11962en_US
bordeaux.volume36en_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires (BMC) - UMR 1034en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04500021
hal.version1
hal.date.transferred2024-03-11T15:29:34Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Transplant%20International&amp;rft.date=2023-01-01&amp;rft.volume=36&amp;rft.spage=11962&amp;rft.epage=11962&amp;rft.eissn=1432-2277&amp;rft.issn=1432-2277&amp;rft.au=CHAMBORD,%20Jeremy&amp;CHAUVEAU,%20Bertrand&amp;DJABAROUTI,%20Sarah&amp;VIGNAUD,%20Jean&amp;TATON,%20Benjamin&amp;rft.genre=article


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