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Healthcare-associated infections in patients with severe COVID-19 supported with extracorporeal membrane oxygenation: a nationwide cohort study
dc.rights.license | open | en_US |
hal.structure.identifier | Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] | |
hal.structure.identifier | Centre d'Investigation Clinique [Rennes] [CIC] | |
hal.structure.identifier | Nutrition, Métabolismes et Cancer [NuMeCan] | |
dc.contributor.author | NESSELER, Nicolas | |
hal.structure.identifier | Institut de recherche en santé, environnement et travail [Irset] | |
hal.structure.identifier | Centre d'Investigation Clinique [Rennes] [CIC] | |
hal.structure.identifier | Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] | |
dc.contributor.author | MANSOUR, Alexandre | |
hal.structure.identifier | Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases [ICAN] | |
dc.contributor.author | SCHMIDT, Matthieu | |
hal.structure.identifier | Laboratoire de Recherche Vasculaire Translationnelle [LVTS (UMR_S_1148 / U1148)] | |
dc.contributor.author | PARA, Marylou | |
hal.structure.identifier | Assistance Publique - Hôpitaux de Marseille [APHM] | |
dc.contributor.author | PORTO, Alizée | |
hal.structure.identifier | Nanomédecine Régénérative [NanoRegMed] | |
dc.contributor.author | FALCOZ, Pierre-Emmanuel | |
hal.structure.identifier | Institut Mondor de Recherche Biomédicale [IMRB] | |
dc.contributor.author | MONGARDON, Nicolas | |
hal.structure.identifier | Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] | |
hal.structure.identifier | Centre d'Investigation Clinique [Rennes] [CIC] | |
dc.contributor.author | FOUGEROU, Claire | |
hal.structure.identifier | Case Western Reserve University [Cleveland] | |
dc.contributor.author | ROSS, James | |
hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
dc.contributor.author | BEURTON, Antoine | |
hal.structure.identifier | Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA] | |
dc.contributor.author | GAIDE-CHEVRONNAY, Lucie | |
dc.contributor.author | GUINOT, Pierre-Grégoire | |
hal.structure.identifier | Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases [ICAN] | |
dc.contributor.author | LEBRETON, Guillaume | |
hal.structure.identifier | Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] | |
hal.structure.identifier | Laboratoire Traitement du Signal et de l'Image [LTSI] | |
dc.contributor.author | FLECHER, Erwan | |
hal.structure.identifier | Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD] | |
dc.contributor.author | VINCENTELLI, André | |
hal.structure.identifier | Centre hospitalier de Saint-Brieuc [Hôpital Yves Le Foll] [CH Saint-Brieuc] | |
dc.contributor.author | MASSART, Nicolas | |
dc.contributor.author | FOUQUET, Olivier | |
dc.contributor.author | PIERROT, Marc | |
dc.contributor.author | CHOCRON, Sidney | |
dc.contributor.author | FLICOTEAUX, Guillaume | |
dc.contributor.author | MAURIAT, Philippe | |
dc.contributor.author | OUATTARA, Alexandre | |
dc.contributor.author | ROZE, Hadrien | |
dc.contributor.author | HUET, Olivier | |
dc.contributor.author | FISCHER, Marc-Olivier | |
dc.contributor.author | BELLAÏCHE, Raphel | |
dc.contributor.author | CONSTANT, Ophélie | |
dc.contributor.author | DE ROUX, Quentin | |
dc.contributor.author | ANDRÉ, L. | |
dc.contributor.author | MEFFERT, Arnaud | |
dc.contributor.author | MERLE, Jean-Claude | |
dc.contributor.author | PICARD, Lucile | |
dc.contributor.author | SKRIPKINA, Elena | |
dc.contributor.author | FOLLIGUET, Thierry | |
dc.contributor.author | FIORE, Antonio | |
dc.contributor.author | D’OSTREVY, Nicolas | |
dc.contributor.author | MORGAN, Marie-Catherine | |
dc.contributor.author | NGUYEN, Maxime | |
dc.contributor.author | TERZI, Nicolas | |
dc.contributor.author | COLIN, Gwenhaël | |
dc.contributor.author | FABRE, Olivier | |
dc.contributor.author | ASTANEH, Arash | |
dc.contributor.author | ISSARD, Justin | |
dc.contributor.author | FADEL, Elie | |
dc.contributor.author | FABRE, Dominique | |
dc.contributor.author | GUIHAIRE, Julien | |
dc.contributor.author | ION, Iolande | |
dc.contributor.author | MENAGER, Jean Baptiste | |
dc.contributor.author | MITILIAN, Delphine | |
dc.contributor.author | MERCIER, Olaf | |
dc.contributor.author | STEPHAN, François | |
dc.contributor.author | THES, Jacques | |
dc.contributor.author | JOUAN, Jerôme | |
dc.contributor.author | DUBURCQ, Thibault | |
dc.contributor.author | LOOBUYCK, Valentin | |
dc.contributor.author | MOUSSA, Mouhammed | |
dc.contributor.author | MANGANIELLO, Sabrina | |
dc.contributor.author | MUGNIER, Agnes | |
dc.contributor.author | ROUSSE, Natacha | |
dc.contributor.author | DESEBBE, Olivier | |
dc.contributor.author | FELLAHI, Jean-Luc | |
dc.contributor.author | HENAINE, Roland | |
dc.contributor.author | POZZI, Matteo | |
dc.contributor.author | RIAD, Zakaria | |
dc.contributor.author | GUERVILLY, Christophe | |
dc.contributor.author | HRAIECH, Sami | |
dc.contributor.author | PAPAZIAN, Laurent | |
dc.contributor.author | CASTANIER, Matthias | |
dc.contributor.author | CHANAVAZ, Charles | |
dc.contributor.author | CADOZ, Cyril | |
dc.contributor.author | GETTE, Sebastien | |
dc.contributor.author | LOUIS, Guillaume | |
dc.contributor.author | PORTOCARRERO, Erick | |
dc.contributor.author | GAUDARD, Philippe | |
dc.contributor.author | BRINI, Kais | |
dc.contributor.author | BISCHOFF, Nicolas | |
dc.contributor.author | KIMMOUN, Antoine | |
dc.contributor.author | LEVY, Bruno | |
dc.contributor.author | PEREZ, Pierre | |
dc.contributor.author | BOURDIOL, Alexandre | |
dc.contributor.author | HOURMANT, Yannick | |
dc.contributor.author | MAHÉ, Pierre-Joachim | |
dc.contributor.author | ROZEC, Bertrand | |
dc.contributor.author | VOURC’H, Mickaël | |
dc.contributor.author | AUBERT, Stéphane | |
dc.contributor.author | BAZALGETTE, Florian | |
dc.contributor.author | ROGER, Claire | |
dc.contributor.author | JAQUET, Pierre | |
dc.contributor.author | LORTAT-JACOB, Brice | |
dc.contributor.author | MORDANT, Pierre | |
dc.contributor.author | NATAF, Patrick | |
dc.contributor.author | PATRIER, Juliette | |
dc.contributor.author | PROVENCHERE, Sophie | |
dc.contributor.author | ROUÉ, Morgan | |
dc.contributor.author | SONNEVILLE, Romain | |
dc.contributor.author | TRAN-DINH, Alexy | |
dc.contributor.author | WICKY, Paul-Henri | |
dc.contributor.author | AL ZREIBI, Charles | |
dc.contributor.author | CHOLLEY, Bernard | |
dc.contributor.author | GUYONVARCH, Yannis | |
dc.contributor.author | HAMADA, Sophie | |
dc.contributor.author | BARBANTI, Claudio | |
dc.contributor.author | BERTIER, Astrid | |
dc.contributor.author | HARROIS, Anatole | |
dc.contributor.author | MATIELLO, Jordi | |
dc.contributor.author | KERFORNE, Thomas | |
dc.contributor.author | LACROIX, Corentin | |
dc.contributor.author | BRECHOT, Nicolas | |
dc.contributor.author | COMBES, Alain | |
dc.contributor.author | CHOMMELOUX, Juliette | |
dc.contributor.author | D’ALESSANDRO, Cosimo | |
dc.contributor.author | DEMONDION, Pierre | |
dc.contributor.author | DEMOULE, Alexandre | |
dc.contributor.author | DRES, Martin | |
dc.contributor.author | FADEL, Guillaume | |
dc.contributor.author | FARTOUKH, Muriel | |
dc.contributor.author | HEKIMIAN, Guillaume | |
dc.contributor.author | JUVIN, Charles | |
dc.contributor.author | LEPRINCE, Pascal | |
dc.contributor.author | LEVY, David | |
dc.contributor.author | LUYT, Charles Edouard | |
dc.contributor.author | SCHOELL, Thibaut | |
dc.contributor.author | FILLÂTRE, Pierre | |
dc.contributor.author | JONAS, Maud | |
dc.contributor.author | ALLOU, Nicolas | |
dc.contributor.author | MUCCIO, Salvatore | |
dc.contributor.author | DI PERNA, Dario | |
dc.contributor.author | RUGGIERI, Vito-Giovanni | |
dc.contributor.author | MOURVILLIER, Bruno | |
dc.contributor.author | ANSELMI, Amedeo | |
dc.contributor.author | BOUNADER, Karl | |
dc.contributor.author | LAUNEY, Yoann | |
dc.contributor.author | LEBOUVIER, Thomas | |
dc.contributor.author | PARASIDO, Alessandro | |
dc.contributor.author | REIZINE, Florian | |
dc.contributor.author | ESVAN, Maxime | |
dc.contributor.author | SEGUIN, Philippe | |
dc.contributor.author | BESNIER, Emmanuel | |
dc.contributor.author | CARPENTIER, Dorothée | |
dc.contributor.author | CLAVIER, Thomas | |
dc.contributor.author | OLLAND, Anne | |
dc.contributor.author | VILLARD, Marion | |
dc.contributor.author | BOUNES, Fanny | |
dc.contributor.author | LABASTE, François | |
dc.contributor.author | MINVILLE, Vincent | |
dc.contributor.author | GUILLON, Antoine | |
dc.contributor.author | FEDUN, Yannick | |
dc.date.accessioned | 2024-03-11T14:28:35Z | |
dc.date.available | 2024-03-11T14:28:35Z | |
dc.date.issued | 2024-02-20 | |
dc.identifier.issn | 1364-8535 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/188685 | |
dc.description.abstractEn | Background Both critically ill patients with coronavirus disease 2019 (COVID-19) and patients receiving extracorporeal membrane oxygenation (ECMO) support exhibit a high incidence of healthcare-associated infections (HAI). However, data on incidence, microbiology, resistance patterns, and the impact of HAI on outcomes in patients receiving ECMO for severe COVID-19 remain limited. We aimed to report HAI incidence and microbiology in patients receiving ECMO for severe COVID-19 and to evaluate the impact of ECMO-associated infections (ECMO-AI) on in-hospital mortality. Methods For this study, we analyzed data from 701 patients included in the ECMOSARS registry which included COVID-19 patients supported by ECMO in France. Results Among 602 analyzed patients for whom HAI and hospital mortality data were available, 214 (36%) had ECMO-AI, resulting in an incidence rate of 27 ECMO-AI per 1000 ECMO days at risk. Of these, 154 patients had bloodstream infection (BSI) and 117 patients had ventilator-associated pneumonia (VAP). The responsible microorganisms were Enterobacteriaceae (34% for BSI and 48% for VAP), Enterococcus species (25% and 6%, respectively) and non-fermenting Gram-negative bacilli (13% and 20%, respectively). Fungal infections were also observed (10% for BSI and 3% for VAP), as were multidrug-resistant organisms (21% and 15%, respectively). Using a Cox multistate model, ECMO-AI were not found associated with hospital death (HR = 1.00 95% CI [0.79–1.26], p = 0.986). Conclusions In a nationwide cohort of COVID-19 patients receiving ECMO support, we observed a high incidence of ECMO-AI. ECMO-AI were not found associated with hospital death. Trial registration number NCT04397588 (May 21, 2020). | |
dc.language.iso | EN | en_US |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject.en | Bloodstream infections | |
dc.subject.en | ECLS | |
dc.subject.en | Nosocomial infections | |
dc.subject.en | SARS-CoV 2 | |
dc.subject.en | Ventilator-associated pneumonia | |
dc.subject.mesh | Humans | |
dc.subject.mesh | COVID-19 | |
dc.subject.mesh | Cohort Studies | |
dc.subject.mesh | Extracorporeal Membrane Oxygenation | |
dc.subject.mesh | Cross Infection | |
dc.subject.mesh | Pneumonia, Ventilator-Associated | |
dc.subject.mesh | Sepsis | |
dc.subject.mesh | Delivery of Health Care | |
dc.subject.mesh | Retrospective Studies | |
dc.title.en | Healthcare-associated infections in patients with severe COVID-19 supported with extracorporeal membrane oxygenation: a nationwide cohort study | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1186/s13054-024-04832-3 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Ingénierie biomédicale | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
dc.identifier.pubmed | 38374103 | en_US |
bordeaux.journal | Critical Care | en_US |
bordeaux.page | 54 | en_US |
bordeaux.volume | 28 | en_US |
bordeaux.hal.laboratories | Biologie des maladies cardiovasculaires (BMC) - UMR 1034 | en_US |
bordeaux.issue | 1 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.import.source | hal | |
hal.identifier | hal-04477794 | |
hal.version | 1 | |
hal.popular | non | en_US |
hal.audience | Internationale | en_US |
hal.export | false | |
workflow.import.source | hal | |
dc.rights.cc | CC BY | en_US |
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