Sex-specific DNA methylation and transcription of zbtb38 and effects of gene–environment interactions on its natural antisense transcript in zebrafish
| dc.rights.license | open | en_US |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | PIERRON, Fabien | |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | DARAMY, Flore | |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | HEROIN, Debora | |
| hal.structure.identifier | Pluridisciplinarité au service de l’observation et de la recherche en environnement et astronomie [UMS POREA] | |
| dc.contributor.author | DAFFE, Guillemine | |
| hal.structure.identifier | Centre de Bioinformatique de Bordeaux [CBIB] | |
| hal.structure.identifier | Université de Bordeaux [UB] | |
| dc.contributor.author | BARRÉ, Aurélien | |
| hal.structure.identifier | Génome et Transcriptome - Plateforme Génomique [GeT-PlaGe] | |
| dc.contributor.author | BOUCHEZ, Olivier | |
| hal.structure.identifier | Centre de Bioinformatique de Bordeaux [CBIB] | |
| hal.structure.identifier | Institut de biochimie et génétique cellulaires [IBGC] | |
| dc.contributor.author | NIKOLSKI, Macha
IDREF: 134506049 | |
| dc.date.accessioned | 2024-03-07T09:18:20Z | |
| dc.date.available | 2024-03-07T09:18:20Z | |
| dc.date.issued | 2023 | |
| dc.identifier.issn | 1559-2294 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/188616 | |
| dc.description.abstractEn | There is increasing evidence for the involvement of epigenetics in sex determination, maintenance and plasticity, from plants to humans. In our previous work we reported a transgenerational feminization of a zebrafish population for which the first generation was exposed to cadmium, a metal with endocrine disrupting effects. In this study, starting from the previously performed whole methylome analysis, we focused on the zbtb38 gene and hypothesized that it could be involved in sex differentiation and Cd-induced offspring feminization. We observed sex-specific patterns of both DNA methylation and RNA transcription levels of zbtb38. We also discovered that the non-coding exon 3 of zbtb38 encodes for a natural antisense transcript (NAT). The activity of this NAT was found to be influenced by both genetic and environmental factors. Furthermore, increasing transcription levels of this NAT in parental gametes was highly correlated with offspring sex ratios. Since zbtb38 itself encodes for a transcription factor that binds methylated DNA, our results support a non-negligible role of zbtb38 not only in orchestrating the sex-specific transcriptome (i.e. sex differentiation) but also, via its NAT, offspring sex ratios. | |
| dc.description.sponsorship | Effets transgénérationnels des polluants chez les poissons: l'épigénétique et son implication en écotoxicologie - ANR-16-CE34-0008 | en_US |
| dc.language.iso | EN | en_US |
| dc.subject.en | Sex determination | |
| dc.subject.en | epigenetics | |
| dc.subject.en | offspring sex ratio | |
| dc.subject.en | environment | |
| dc.subject.en | transgenerational | |
| dc.subject.en | pollutant | |
| dc.title.en | Sex-specific DNA methylation and transcription of zbtb38 and effects of gene–environment interactions on its natural antisense transcript in zebrafish | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1080/15592294.2023.2260963 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Toxicologie/Ecotoxicologie | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Biologie animale/Zoologie des vertébrés | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Génomique, Transcriptomique et Protéomique [q-bio.GN] | en_US |
| bordeaux.journal | Epigenetics | en_US |
| bordeaux.page | 2260963 | en_US |
| bordeaux.volume | 18 | en_US |
| bordeaux.hal.laboratories | EPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.team | EA | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-04237564 | |
| hal.version | 1 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Epigenetics&rft.date=2023&rft.volume=18&rft.issue=1&rft.spage=2260963&rft.epage=2260963&rft.eissn=1559-2294&rft.issn=1559-2294&rft.au=PIERRON,%20Fabien&DARAMY,%20Flore&HEROIN,%20Debora&DAFFE,%20Guillemine&BARR%C3%89,%20Aur%C3%A9lien&rft.genre=article |
