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Association between Helicobacter pylori infection and incident risk of dementia: The AMI cohort

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHERNANDEZ-RUIZ, Virgilio
hal.structure.identifierBoRdeaux Institute in onCology [Inserm U1312 - BRIC]
dc.contributor.authorROUBAUD-BAUDRON, Claire
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorVON CAMPE, Hugo
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRETUERTO, Noelia
dc.contributor.authorMEGRAUD, Francis
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorAMIEVA, Helene
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPERES, Karine
ORCID: 0000-0002-0720-0684
IDREF: 080634001
dc.date.accessioned2024-02-22T11:49:21Z
dc.date.available2024-02-22T11:49:21Z
dc.date.issued2024-01-23
dc.identifier.issn1532-5415en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/188309
dc.description.abstractEnBACKGROUND: Chronic infectious diseases are increasingly being considered as potential contributors to dementia risk. Among those infections, Helicobacter pylori, the main cause of chronic gastritis worldwide, has been suggested. As the prevalence of H. pylori infection has decreased, the main objective of this work was to reconsider the association between H. pylori infection and the risk of incident dementia, including Alzheimer's disease. METHODS: Prospective cohort of 689 older (≥65 years) agricultural workers from Southwest France. Descriptive and comparative analyses were performed according to H. pylori status determined by serology at baseline. The risk of incident dementia according to H. pylori status over a 7-year follow-up was explored by survival analyses: Kaplan-Meier curve and Cox proportional hazards models. RESULTS: Two-hundred (29.0%) participants were H. pylori-positive at baseline. Compared to H. pylori-negative participants, they showed worse cognitive performances at baseline. Eighty-five incident dementia cases were diagnosed during the follow-up period. After adjustment for age, sex, education, apolipoprotein ε4, and several cardiovascular risk factors, H. pylori remained associated with an increased risk of dementia (HR 1.70, 95% CI, 1.05-2.74). The risk was stronger for Alzheimer's disease (HR 2.85, 95% CI, 1.58-5.12). CONCLUSIONS: Despite an observed decrease in H. pylori infection prevalence, this study provides evidence for the association between H. pylori infection and dementia. These results should encourage further research on the mechanisms underlying the contribution of infectious diseases to pathological brain aging, especially the influence of gut inflammation on the brain.
dc.language.isoENen_US
dc.subject.enAlzheimer's disease
dc.subject.enH. pylori
dc.subject.enDementia
dc.title.enAssociation between Helicobacter pylori infection and incident risk of dementia: The AMI cohort
dc.title.alternativeJ Am Geriatr Socen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/jgs.18748en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed38258504en_US
bordeaux.journalJournal of the American Geriatrics Societyen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamACTIVE_BPHen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04472757
hal.version1
hal.date.transferred2024-02-22T11:49:24Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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