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Agricultural exposure and risk of ovarian cancer in the AGRIculture and CANcer (AGRICAN) cohort

dc.rights.licenseopenen_US
dc.contributor.authorRENIER, Marine
dc.contributor.authorHIPPERT, Juliette
dc.contributor.authorLOUIS-BASTIEN, Weiswald
dc.contributor.authorTUAL, Severine
dc.contributor.authorMERYET-FIGUIERE, Matthieu
dc.contributor.authorVIGNERON, Nicolas
dc.contributor.authorMARCOTULLIO, Elisabeth
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBALDI, Isabelle
dc.contributor.authorLEBAILLY, Pierre
dc.date.accessioned2024-02-20T13:08:46Z
dc.date.available2024-02-20T13:08:46Z
dc.date.issued2024-02-01
dc.identifier.issn1470-7926en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/188259
dc.description.abstractEnBACKGROUND: Ovarian cancer is rare with a poor prognosis and few established risk factors. Hormones and reproductive factors significantly impact its development, suggesting a potential link with endocrine disrupters. METHODS: In the AGRICAN cohort, 59 391 female farmers completed data on lifelong agricultural exposures and reproductive life. Cox models with attained age as timescale (HR and 95% CI) were used. The role of hormonal factors as potential confounders was considered along with specific time windows for exposure (childhood, puberty and menopause). Female farmers were the reference group (for the principal analyses). RESULTS: Between enrolment (2005-2007) and the end of follow-up (31 December 2017), 262 incident ovarian cancers were identified. An increased risk was observed for females involved in pigs (HR=2.12 (95% CI 1.27 to 3.52)) including during puberty (HR=1.83 (95% CI 1.13 to 2.94)), fruit-growing (HR=2.17 (95% CI 1.09 to 4.30)) and potato seed treatment (HR=2.81 (95% CI 1.29 to 6.09)). Conversely, females born on farms growing grain cereals (HR=0.64 (95% CI 0.46 to 0.90)) or pig-breeding (HR=0.78 (95% CI 0.55 to 1.12)) presented a reduced risk of ovarian cancer. Triazine herbicide exposure was not associated with ovarian cancer. The effect of agricultural exposures remained unchanged in multivariate models considering contraception, parity, puberty age, menopause age and body mass index. CONCLUSION: This study is the first to assess the association between specific agricultural exposures and ovarian cancer comprehensively. Some of the positive associations observed suggest that some pesticide exposure (especially during puberty) could play a role in the development of ovarian cancer. On the other hand, agricultural exposure during early life could have a protective effect, as observed for lung cancer among farmers. Finally, we did not confirm the previous putative effect of exposure to triazine herbicides.
dc.language.isoENen_US
dc.subject.enAgriculture
dc.subject.enFarmers
dc.subject.enPesticides
dc.title.enAgricultural exposure and risk of ovarian cancer in the AGRIculture and CANcer (AGRICAN) cohort
dc.title.alternativeOccup Environ Meden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1136/oemed-2023-109089en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed38199811en_US
bordeaux.journalOccupational and Environmental Medicineen_US
bordeaux.page75-83en_US
bordeaux.volume81en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDLigue Contre le Canceren_US
bordeaux.identifier.funderIDMutualité Sociale Agricoleen_US
bordeaux.identifier.funderIDFondation de Franceen_US
bordeaux.identifier.funderIDAssociation pour la Recherche sur le Canceren_US
bordeaux.identifier.funderIDAgence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travailen_US
bordeaux.identifier.funderIDOffice National de l’Eau et des Milieux Aquatiquesen_US
hal.identifierhal-04468339
hal.version1
hal.date.transferred2024-02-20T13:08:48Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Occupational%20and%20Environmental%20Medicine&rft.date=2024-02-01&rft.volume=81&rft.issue=2&rft.spage=75-83&rft.epage=75-83&rft.eissn=1470-7926&rft.issn=1470-7926&rft.au=RENIER,%20Marine&HIPPERT,%20Juliette&LOUIS-BASTIEN,%20Weiswald&TUAL,%20Severine&MERYET-FIGUIERE,%20Matthieu&rft.genre=article


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