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Long-term Effects of Kidney Transplantation Compared With Dialysis on Intima-media Thickness in Children-Results From the 4C-T Study

dc.rights.licenseopenen_US
dc.contributor.authorGRABITZ, Carl
dc.contributor.authorSUGIANTO, Rizky I
dc.contributor.authorDOYON, Anke
dc.contributor.authorAZUKAITIS, Karolis
dc.contributor.authorANARAT, Ali
dc.contributor.authorBACCHETTA, Justine
dc.contributor.authorBAYAZIT, Aysun K
dc.contributor.authorBULUT, Ipek K
dc.contributor.authorCALISKAN, Salim
dc.contributor.authorCANPOLAT, Nur
dc.contributor.authorDUZOVA, Ali
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHARAMBAT, Jerome
dc.contributor.authorKIYAK, Aysel
dc.contributor.authorLONGO, Germana
dc.contributor.authorOBRYCKI, Lukasz
dc.contributor.authorPARIPOVIC, Dusan
dc.contributor.authorTHURN-VALSASSINA, Daniela
dc.contributor.authorYILMAZ, Alev
dc.contributor.authorSHROFF, Rukshana
dc.contributor.authorSCHAEFER, Franz
dc.contributor.authorSCHMIDT, Bernhard M W
dc.contributor.authorMELK, Anette
dc.date.accessioned2024-02-20T11:03:38Z
dc.date.available2024-02-20T11:03:38Z
dc.date.issued2024-01-16
dc.identifier.issn1534-6080en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/188256
dc.description.abstractEnBACKGROUND: Children requiring kidney replacement therapy experience high burden of cardiovascular (CV) disease leading to increased mortality. Intima-media thickness (IMT) indicating atherosclerosis is a validated surrogate marker for future CV events. METHODS: We investigated the effect of different treatment modalities (dialysis, preemptive kidney transplantation (KTx), late KTx after dialysis) on IMT by multivariable linear mixed-effect modeling. Patients were enrolled in a prospective cohort study. RESULTS: A total of 261 analyzed children had a mean follow-up of 3 y. Children after preemptive and late KTx had lower levels of IMT when compared with dialysis. Using an interaction term, a significant progression of IMT over time was seen during dialysis (β = 0.0053 mm/y, P  =  0.004). IMT before the start of therapy was the most influential determinant in all models. Low IMT was associated with maintenance steroid treatment after preemptive KTx. High IMT on dialysis was associated with higher systolic blood pressure, lower body mass index, lower serum albumin, and lower bicarbonate. CONCLUSIONS: IMT remained rather stable in children several years after KTx. In contrast, children on dialysis had higher IMT values, which increased over time. In these children, blood pressure control, calorie and protein intake, and acid-base homeostasis seem important. Taken together, children might profit from early transplantation to limit accumulation of CV risk.
dc.language.isoENen_US
dc.title.enLong-term Effects of Kidney Transplantation Compared With Dialysis on Intima-media Thickness in Children-Results From the 4C-T Study
dc.title.alternativeTransplantationen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/tp.0000000000004881en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed38227773en_US
bordeaux.journalTransplantationen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04467939
hal.version1
hal.date.transferred2024-02-20T11:03:41Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Transplantation&rft.date=2024-01-16&rft.eissn=1534-6080&rft.issn=1534-6080&rft.au=GRABITZ,%20Carl&SUGIANTO,%20Rizky%20I&DOYON,%20Anke&AZUKAITIS,%20Karolis&ANARAT,%20Ali&rft.genre=article


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