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Estimation of Improvements in Mortality in Spectrum Among Adults With HIV Receiving Antiretroviral Therapy in High-Income Countries

dc.rights.licenseopenen_US
dc.contributor.authorTRICKEY, Adam
dc.contributor.authorGLAUBIUS, Robert
dc.contributor.authorPANTAZIS, Nikos
dc.contributor.authorZANGERLE, Robert
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorWITTKOP, Linda
dc.contributor.authorVEHRESCHILD, Janne
dc.contributor.authorGRABAR, Sophie
dc.contributor.authorCAVASSINI, Matthias
dc.contributor.authorTEIRA, Ramon
dc.contributor.authorD'ARMINIO MONFORTE, Antonella
dc.contributor.authorCASABONA, Jordi
dc.contributor.authorVAN SIGHEM, Ard
dc.contributor.authorJARRIN, Inma
dc.contributor.authorINGLE, Suzanne M
dc.contributor.authorSTERNE, Jonathan A C
dc.contributor.authorIMAI-EATON, Jeffrey W
dc.contributor.authorJOHNSON, Leigh F
dc.date.accessioned2024-02-20T10:37:55Z
dc.date.available2024-02-20T10:37:55Z
dc.date.issued2024-01-01
dc.identifier.issn1944-7884en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/188254
dc.description.abstractEnINTRODUCTION: Mortality rates for people living with HIV (PLHIV) on antiretroviral therapy (ART) in high-income countries continue to decline. We compared mortality rates among PLHIV on ART in Europe for 2016-2020 with Spectrum's estimates. METHODS: The AIDS Impact Module in Spectrum is a compartmental HIV epidemic model coupled with a demographic population projection model. We used national Spectrum projections developed for the 2022 HIV estimates round to calculate mortality rates among PLHIV on ART, adjusting to the age/country distribution of PLHIV starting ART from 1996 to 2020 in the Antiretroviral Therapy Cohort Collaboration (ART-CC)'s European cohorts. RESULTS: In the ART-CC, 11,504 of 162,835 PLHIV died. Between 1996-1999 and 2016-2020, AIDS-related mortality in the ART-CC decreased from 8.8 (95% CI: 7.6 to 10.1) to 1.0 (0.9-1.2) and from 5.9 (4.4-8.1) to 1.1 (0.9-1.4) deaths per 1000 person-years among men and women, respectively. Non-AIDS-related mortality decreased from 9.1 (7.9-10.5) to 6.1 (5.8-6.5) and from 7.0 (5.2-9.3) to 4.8 (4.3-5.2) deaths per 1000 person-years among men and women, respectively. Adjusted all-cause mortality rates in Spectrum among men were near ART-CC estimates for 2016-2020 (Spectrum: 7.02-7.47 deaths per 1000 person-years) but approximately 20% lower in women (Spectrum: 4.66-4.70). Adjusted excess mortality rates in Spectrum were 2.5-fold higher in women and 3.1-3.4-fold higher in men in comparison to the ART-CC's AIDS-specific mortality rates. DISCUSSION: Spectrum's all-cause mortality estimates among PLHIV are consistent with age/country-controlled mortality observed in ART-CC, with some underestimation of mortality among women. Comparing results suggest that 60%-70% of excess deaths among PLHIV on ART in Spectrum are from non-AIDS causes.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAIDS mortality
dc.subject.enexcess mortality
dc.subject.enmodelling
dc.subject.enparameters
dc.subject.enEurope
dc.subject.enhigh income
dc.title.enEstimation of Improvements in Mortality in Spectrum Among Adults With HIV Receiving Antiretroviral Therapy in High-Income Countries
dc.title.alternativeJ Acquir Immune Defic Syndren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/qai.0000000000003326en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed38180742en_US
bordeaux.journalJournal of Acquired Immune Deficiency Syndromes - JAIDSen_US
bordeaux.pagee89-e96en_US
bordeaux.volume95en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1Sen_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionINRIAen_US
bordeaux.teamSISTM_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04467807
hal.version1
hal.date.transferred2024-02-20T10:37:59Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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