Afficher la notice abrégée

dc.rights.licenseopenen_US
dc.contributor.authorROZE, Jean-Christophe
dc.contributor.authorBACCHETTA, Justine
dc.contributor.authorLAPILLONNE, Alexandre
dc.contributor.authorBOUDRED, Farid
dc.contributor.authorPICAUD, Jean-Charles
dc.contributor.authorMARCHAND-MARTIN, Laetitia
dc.contributor.authorBRUEL-TESSOULIN, Alexandra
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHARAMBAT, Jerome
IDREF: 110567358
dc.contributor.authorBIRAN, Valerie
dc.contributor.authorNUYT, Anne-Monique
dc.contributor.authorDARMAUN, Dominique
dc.contributor.authorANCEL, Pierre-Yves
dc.date.accessioned2024-02-20T08:44:42Z
dc.date.available2024-02-20T08:44:42Z
dc.date.issued2024-01-02
dc.identifier.issn2047-9980en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/188249
dc.description.abstractEnBACKGROUND: The life course of individuals born very premature is a topic of increasing concern. The association between high early amino acid intake and later high blood pressure (HBP) in preterm neonates is debated. METHODS AND RESULTS: In a national, prospective, population-based birth cohort, EPIPAGE-2 (Etude Epidémiologique sur Petits Ages Gestationnels), we assessed blood pressure at 5 years. Eligible infants were those born between 24 and 29 weeks of gestation. Infants were distributed in 2 groups of 717 infants matched on propensity score on whether or not they were exposed to high amino acid intake (>3.5 g/kg per day at day 7); 455 control term infants were also enrolled. A value ≥95th percentile of reference values for age and height defined systolic or diastolic HBP. Blood pressure at 5 years of age was assessed for 389 and 385 children in the exposed and nonexposed groups, respectively. Rates (in percent) of systolic and diastolic HBP were 18.0% (95% CI, 14.5%-22.2%), 13.3% (95% CI, 10.3%-17.0%), 8.5% (95% CI, 6.5%-11.1%), and 9.0% (95% CI, 6.6%-12.3%), 10.2% (95% CI, 7.5%-13.6%), and 5.4% (95% CI, 3.8%-7.6%) in exposed, nonexposed, and term-born groups, respectively. Exposure to high early amino acid intake and maximal serum creatinine (by 50 μmol/L) between day 3 and day 7 were 2 independent risk factors for systolic HBP (adjusted odds ratio [aOR], 1.60 [95% CI, 1.05-2.43] and aOR, 1.59 [95% CI, 1.12-2.26], respectively) but not for diastolic HBP (aOR, 0.84 [95% CI, 0.50-1.39] and aOR, 1.09 [95% CI, 0.71-1.67], respectively). After adjustment for 5-year weight Z score, the aOR between high early amino acid intake and systolic HBP was 1.50 [95% CI, 0.98-2.30]. CONCLUSIONS: These results suggest that mechanisms of childhood systolic HBP involve neonatal renal challenge by high amino acid intake or dysfunction.
dc.description.sponsorshipPlateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssanceen_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enAmino acid intake
dc.subject.enFollow-up
dc.subject.enHigh blood pressure
dc.subject.enPreterm infants
dc.subject.enProtein intake
dc.title.enHigh Amino Acid Intake in Early Life Is Associated With Systolic but Not Diastolic Arterial Hypertension at 5 Years of Age in Children Born Very Preterm
dc.title.alternativeJ Am Heart Assocen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1161/jaha.123.032804en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed38156453en_US
bordeaux.journalJournal of the American Heart Associationen_US
bordeaux.pagee032804en_US
bordeaux.volume13en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_ BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut pour la Recherche en Santé Publiqueen_US
bordeaux.identifier.funderIDInstitut National Du Canceren_US
bordeaux.identifier.funderIDMinistère de la Santéen_US
bordeaux.identifier.funderIDCaisse nationale de solidarité pour l'autonomieen_US
hal.identifierhal-04467383
hal.version1
hal.date.transferred2024-02-20T08:44:46Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20the%20American%20Heart%20Association&rft.date=2024-01-02&rft.volume=13&rft.issue=1&rft.spage=e032804&rft.epage=e032804&rft.eissn=2047-9980&rft.issn=2047-9980&rft.au=ROZE,%20Jean-Christophe&BACCHETTA,%20Justine&LAPILLONNE,%20Alexandre&BOUDRED,%20Farid&PICAUD,%20Jean-Charles&rft.genre=article


Fichier(s) constituant ce document

Thumbnail
Thumbnail

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée