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Lifetime Ambient Ultraviolet Radiation Exposure and Incidence of Age-Related Macular Degeneration

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorAMARI, Bouchra
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMERLE, Benedicte
ORCID: 0000-0003-1332-0954
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorKOROBELNIK, Jean-Francois
ORCID: 0000-0002-4438-9535
IDREF: 028739272
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELYFER, Marie-Noelle
dc.contributor.authorBONIOL, Mathieu
dc.contributor.authorDORE, Jean-Francois
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELCOURT, Cecile
ORCID: 0000-0002-2099-0481
IDREF: 035105291
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOUGNARD-GREGOIRE, Audrey
dc.date.accessioned2024-02-20T08:14:26Z
dc.date.available2024-02-20T08:14:26Z
dc.date.issued2024-01-01
dc.identifier.issn1539-2864en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/188247
dc.description.abstractEnSupplemental Digital Content is Available in the Text.This article reports associations between lifetime ambient ultraviolet radiation exposure and incidence of age-related macular degeneration. The study identified an increased risk of early age-related macular degeneration with moderate lifetime ultraviolet radiation exposure, but no dose-response relationship was established. Furthermore, no significant association was discerned between cumulative lifetime ultraviolet radiation exposure and incident advanced age-related macular degeneration. Purpose:To investigate the link between lifelong exposure to ultraviolet radiation (UVR) and the development of age-related macular degeneration (AMD).Methods:The Alienor study is a prospective population-based cohort involving 963 residents of Bordeaux, France, older than 73 years. A subset of 614 participants for advanced AMD and 422 participants for early AMD were included in the analysis. The participants' residential history combined with UVR estimates from the EuroSun satellite were used to estimate the amount of ambient UVR they have been exposed to over their lifetime. Age-related macular degeneration was classified from retinal fundus photographs and spectral domain optical coherence tomography at 2 to 3 years intervals over the 2006 to 2017 period. Associations between cumulative exposure to ultraviolet A, ultraviolet B, and total (total UV) and the incidence of early and advanced AMD were estimated using multivariate Cox models.Results:Intermediate quartiles of total UV, ultraviolet A, and ultraviolet B exposures were associated with a higher risk for incident early AMD (Hazard Ratio [HR] =2.01 [95% confidence interval [CI] = 1.27-3.13], HR = 2.20 [95% CI = 1.38-3.50], HR = 1.79 [95% CI = 1.13-2.80], respectively) as compared with the lower quartile. However, this risk did not further increase in the highest quartiles of exposure. None of the three types of UVR exposure was significantly associated with incident advanced AMD.Conclusion:Despite an increased risk with intermediate compared with low UVR exposure, our study cannot confirm a dose-response relationship of UVR exposure with early AMD onset.
dc.language.isoENen_US
dc.title.enLifetime Ambient Ultraviolet Radiation Exposure and Incidence of Age-Related Macular Degeneration
dc.title.alternativeRetinaen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/iae.0000000000003917en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed38117581en_US
bordeaux.journalRETINA. The Journal of Retinal and Vitreous Diseasesen_US
bordeaux.page28-36en_US
bordeaux.volume44en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04467313
hal.version1
hal.date.transferred2024-02-20T08:14:28Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=RETINA.%20The%20Journal%20of%20Retinal%20and%20Vitreous%20Diseases&rft.date=2024-01-01&rft.volume=44&rft.issue=1&rft.spage=28-36&rft.epage=28-36&rft.eissn=1539-2864&rft.issn=1539-2864&rft.au=AMARI,%20Bouchra&MERLE,%20Benedicte&KOROBELNIK,%20Jean-Francois&DELYFER,%20Marie-Noelle&BONIOL,%20Mathieu&rft.genre=article


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