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Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies

dc.rights.licenseopenen_US
dc.contributor.authorO'KEEFE, James H
dc.contributor.authorTINTLE, Nathan L
dc.contributor.authorHARRIS, William S
dc.contributor.authorO'KEEFE, Evan L
dc.contributor.authorSALA-VILA, Aleix
dc.contributor.authorATTIA, John
dc.contributor.authorGARG, G Manohar
dc.contributor.authorHURE, Alexis
dc.contributor.authorBORK, Christian Sorensen
dc.contributor.authorSCHMIDT, Erik Berg
dc.contributor.authorVENO, Stine Krogh
dc.contributor.authorCHIEN, Kuo-Liong
dc.contributor.authorCHEN, Yun-Yu Amelia
dc.contributor.authorEGERT, Sarah
dc.contributor.authorFELDREICH, Tobias Rudholm
dc.contributor.authorARNLOV, Johan
dc.contributor.authorLIND, Lars
dc.contributor.authorFOROUHI, Nita G
dc.contributor.authorGELEIJNSE, Johanna M
dc.contributor.authorPERTIWI, Kamalita
dc.contributor.authorIMAMURA, Fumiaki
dc.contributor.authorDE MELLO LAAKSONEN, Vanessa
dc.contributor.authorUUSITUPA, W Matti
dc.contributor.authorTUOMILEHTO, Jaakko
dc.contributor.authorLAAKSO, Markku
dc.contributor.authorLANKINEN, Maria Anneli
dc.contributor.authorLAURIN, Danielle
dc.contributor.authorCARMICHAEL, Pierre-Hugues
dc.contributor.authorLINDSAY, Joan
dc.contributor.authorLEANDER, Karin
dc.contributor.authorLAGUZZI, Federica
dc.contributor.authorSWENSON, Brenton R
dc.contributor.authorLONGSTRETH, William T
dc.contributor.authorMANSON, JoAnn E
dc.contributor.authorMORA, Samia
dc.contributor.authorCOOK, Nancy R
dc.contributor.authorMARKLUND, Matti
dc.contributor.authorMELO VAN LENT, Debora
dc.contributor.authorMURPHY, Rachel
dc.contributor.authorGUDNASON, Vilmundur
dc.contributor.authorNINOMIYA, Toshihara
dc.contributor.authorHIRAKAWA, Yoichiro
dc.contributor.authorQIAN, Frank
dc.contributor.authorSUN, Qi
dc.contributor.authorHU, Frank
dc.contributor.authorARDISSON KORAT, Andres V
dc.contributor.authorRISERUS, Ulf
dc.contributor.authorLAZARO, Iolanda
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIERI, Cecilia
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLE GOFF, Melanie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
dc.contributor.authorSTEUR, Marinka
dc.contributor.authorVOORTMAN, Trudy
dc.contributor.authorIKRAM, M Kamran
dc.contributor.authorTANAKA, Toshiko
dc.contributor.authorDAS, Jayanta K
dc.contributor.authorFERRUCCI, Luigi
dc.contributor.authorBANDINELLI, Stefania
dc.contributor.authorTSAI, Michael
dc.contributor.authorGUAN, Weihua
dc.contributor.authorGARG, Parveen
dc.contributor.authorVERSCHUREN, W M Monique
dc.contributor.authorBOER, Jolanda M A
dc.contributor.authorBIOKSTRA, Anneke
dc.contributor.authorVIRTANEN, Jyrki
dc.contributor.authorWAGNER, Michael
dc.contributor.authorWESTRA, Jason
dc.contributor.authorALBUISSON, Luc
dc.contributor.authorYAMAGISHI, Kazumasa
dc.contributor.authorSISCOVICK, David S
dc.contributor.authorLEMAITRE, Rozenn N
dc.contributor.authorMOZAFFARIAN, Dariush
dc.date.accessioned2024-02-19T15:16:33Z
dc.date.available2024-02-19T15:16:33Z
dc.date.issued2024-01-01
dc.identifier.issn1524-4628en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/188241
dc.description.abstractEnBACKGROUND: The effect of marine omega-3 PUFAs on risk of stroke remains unclear.METHODS: We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and hemorrhagic) in 29 international prospective cohorts. Each site conducted a de novo individual-level analysis using a prespecified analytical protocol with defined exposures, covariates, analytical methods, and outcomes; the harmonized data from the studies were then centrally pooled. Multivariable-adjusted HRs and 95% CIs across omega-3 PUFA quintiles were computed for each stroke outcome.RESULTS: Among 183 291 study participants, there were 10 561 total strokes, 8220 ischemic strokes, and 1142 hemorrhagic strokes recorded over a median of 14.3 years follow-up. For eicosapentaenoic acid, comparing quintile 5 (Q5, highest) with quintile 1 (Q1, lowest), total stroke incidence was 17% lower (HR, 0.83 [CI, 0.76-0.91]; P<0.0001), and ischemic stroke was 18% lower (HR, 0.82 [CI, 0.74-0.91]; P<0.0001). For docosahexaenoic acid, comparing Q5 with Q1, there was a 12% lower incidence of total stroke (HR, 0.88 [CI, 0.81-0.96]; P=0.0001) and a 14% lower incidence of ischemic stroke (HR, 0.86 [CI, 0.78-0.95]; P=0.0001). Neither eicosapentaenoic acid nor docosahexaenoic acid was associated with a risk for hemorrhagic stroke. These associations were not modified by either baseline history of AF or prevalent CVD.CONCLUSIONS: Higher omega-3 PUFA levels are associated with lower risks of total and ischemic stroke but have no association with hemorrhagic stroke.
dc.language.isoENen_US
dc.subject.enAtrial fibrillation
dc.subject.enCerebrovascular disease
dc.subject.enFish
dc.subject.enFish oil
dc.subject.enStroke
dc.title.enOmega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies
dc.title.alternativeStrokeen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1161/strokeaha.123.044281en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed38134264en_US
bordeaux.journalStrokeen_US
bordeaux.page50-58en_US
bordeaux.volume55en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04466354
hal.version1
hal.date.transferred2024-05-29T07:29:53Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Stroke&amp;rft.date=2024-01-01&amp;rft.volume=55&amp;rft.issue=1&amp;rft.spage=50-58&amp;rft.epage=50-58&amp;rft.eissn=1524-4628&amp;rft.issn=1524-4628&amp;rft.au=O'KEEFE,%20James%20H&amp;TINTLE,%20Nathan%20L&amp;HARRIS,%20William%20S&amp;O'KEEFE,%20Evan%20L&amp;SALA-VILA,%20Aleix&amp;rft.genre=article


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