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dc.rights.licenseopenen_US
dc.contributor.authorCOLOM-ROCHA, Carles
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorBIS-HUMBERT, Cristian
dc.contributor.authorGARCÍA-FUSTER, Julia
dc.date.accessioned2024-02-19T11:50:26Z
dc.date.available2024-02-19T11:50:26Z
dc.date.issued2023-04
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/188232
dc.description.abstractEnBackground: Binge alcohol drinking is considered a prominent risk factor for the development of alcohol-use disorders, and could be model in rodents through the standard two-bottle preference choice test. The goal was to recreate an intermittent use of alcohol during 3 consecutive days each week to ascertain its potential impact on hippocampal neurotoxicity (neurogenesis and other neuroplasticity markers), and including sex as a biological variable, given the well-known sex differences in alcohol consumption. Methods: Ethanol access was granted to adult Sprague–Dawley rats for 3 consecutive days per week, followed by 4 days of withdrawal, during 6 weeks, mimicking the most common pattern of intake in people, drinking over the weekends in an intensive manner. Hippocampal samples were collected to evaluate signs of neurotoxicity. Results: Female rats consumed significantly more ethanol than males, although intake did not escalate over time. Ethanol preference levels remained below 40% over time and did not differ between sexes. Moderate signs of ethanol neurotoxicity were observed in hippocampus at the level of decreased neuronal progenitors (NeuroD + cells), and these effects were independent of sex. No other signs of neurotoxicity were induced by ethanol voluntary consumption when measured through several key cell fate markers (i.e., FADD, Cyt c, Cdk5, NF-L) by western blot analysis. Conclusions: Overall, the present results suggest that even though we modeled a situation where no escalation in ethanol intake occurred across time, mild signs of neurotoxicity emerged, suggesting that even the use of ethanol during adulthood in a recreational way could lead to certain brain harm. © 2023, The Author(s).
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAlcohol voluntary drinking
dc.subject.enHippocampus
dc.subject.enNeurogenesis
dc.subject.enRat
dc.subject.enSex differences
dc.title.enEvaluating signs of hippocampal neurotoxicity induced by a revisited paradigm of voluntary ethanol consumption in adult male and female Sprague-Dawley rats
dc.title.alternativePharmacol Repen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s43440-023-00464-6en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed36807777en_US
bordeaux.journalPharmacological Reportsen_US
bordeaux.page320-330en_US
bordeaux.volume75en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPsychobiologie de la vulnérabilité à l'addiction aux droguesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDMinisterio de Sanidad, Consumo y Bienestar Socialen_US
hal.identifierhal-04465529
hal.version1
hal.date.transferred2024-02-19T11:50:28Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Pharmacological%20Reports&rft.date=2023-04&rft.volume=75&rft.issue=2&rft.spage=320-330&rft.epage=320-330&rft.au=COLOM-ROCHA,%20Carles&BIS-HUMBERT,%20Cristian&GARC%C3%8DA-FUSTER,%20Julia&rft.genre=article


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