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Transgenerational epigenetic sex determination: Environment experienced by female zebrafish affects offspring sex ratio

dc.rights.licenseopenen_US
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorPIERRON, Fabien
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorLORIOUX, Sophie
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorHEROIN, Debora
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorDAFFE, Guillemine
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorETCHEVERRIA, Bruno
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorCACHOT, Jérôme
ORCID: 0000-0002-1492-9684
IDREF: 19667672X
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorMORIN, Benedicte
IDREF: 178000892
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorDUFOUR, Sylvie
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorGONZALEZ, Patrice
ORCID: 0000-0003-2628-2993
IDREF: 14341917X
dc.date.accessioned2024-02-07T13:49:50Z
dc.date.available2024-02-07T13:49:50Z
dc.date.issued2021
dc.identifier.issn0269-7491en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/187981
dc.description.abstractEnSex determination is a complex process that can be influenced by environment in various taxa. Disturbed environments can affect population sex ratios and thus threaten their viability. Emerging evidences support a role of epigenetic mechanisms, notably DNA methylation, in environmental sex determination (ESD). In this work, using zebrafish as model and a transgenerational experiment comprising 4 successive generations, we report a strength link between the promotor methylation level of three genes in female gonads and population sex ratio. One generation of zebrafish was exposed throughout its lifetime to cadmium (Cd), a non-essential metal, at an environmentally relevant concentration. The subsequent generations were not exposed. At the first and the third generation a subset of individuals was exposed to an elevated temperature, a well-known masculinizing factor in zebrafish. While heat was associated to an increase in the methylation level of cyp19a1a gene and population masculinization, foxl2a/dmrt1 methylation levels appeared to be influenced by Cd and fish density leading to offspring feminization. Ancestral Cd exposure indeed led to a progressive feminization of the population over generations and affected the sex plastic response of zebrafish in response to heat. The effect of Cd on the methylation level of foxl2a was observed until the third generation, supporting potential transgenerational inheritance. Our results support (i) a key role of cyp19a1a methylation in SD in zebrafish in response to environmental cues and (ii) the fact that the environment experienced by parents, namely mothers in the present case, can affect their offspring sex ratio via environment-induced DNA methylation changes in gonads.
dc.description.sponsorshipEffets transgénérationnels des polluants chez les poissons: l'épigénétique et son implication en écotoxicologie - ANR-16-CE34-0008en_US
dc.language.isoENen_US
dc.subject.enDNA methylation
dc.subject.entransgenerational
dc.subject.ensex determination
dc.subject.enplasticity
dc.subject.enecotoxicology
dc.title.enTransgenerational epigenetic sex determination: Environment experienced by female zebrafish affects offspring sex ratio
dc.title.alternativeEnviron. Pollut.en_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.envpol.2021.116864en_US
dc.subject.halSciences du Vivant [q-bio]/Toxicologie/Ecotoxicologieen_US
dc.subject.halSciences du Vivant [q-bio]/Biologie animale/Zoologie des vertébrésen_US
bordeaux.journalEnvironmental Pollutionen_US
bordeaux.page116864en_US
bordeaux.volume277en_US
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamEAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-03434098
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Environmental%20Pollution&rft.date=2021&rft.volume=277&rft.spage=116864&rft.epage=116864&rft.eissn=0269-7491&rft.issn=0269-7491&rft.au=PIERRON,%20Fabien&LORIOUX,%20Sophie&HEROIN,%20Debora&DAFFE,%20Guillemine&ETCHEVERRIA,%20Bruno&rft.genre=article


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