Endocannabinoid-related molecules predict the metabolic efficacy of GLP-1 receptor agonism in humans with obesity
dc.rights.license | open | en_US |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | MATIAS, Isabelle | |
hal.structure.identifier | University of Copenhagen = Københavns Universitet [UCPH] | |
dc.contributor.author | LEHMANN, E.W. | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | ZIZZARI, Philippe | |
hal.structure.identifier | University of Copenhagen = Københavns Universitet [UCPH] | |
dc.contributor.author | BYBERG, Sarah | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | COTA, Daniela | |
hal.structure.identifier | University of Copenhagen = Københavns Universitet [UCPH] | |
dc.contributor.author | TOREKOV, Signe Sørensen | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | QUARTA, Carmelo | |
dc.date.accessioned | 2024-01-30T13:13:05Z | |
dc.date.available | 2024-01-30T13:13:05Z | |
dc.date.issued | 2023-11-04 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/187635 | |
dc.description.abstractEn | Objective: N-acylethanolamines (NAEs) include endocannabinoid (EC) and EC-related molecules that impact the anti-obesity and anti-diabetic efficacy of glucagon-like peptide-1 receptor agonists (GLP-1RA) in animal studies. However, the clinical relevance of these findings remains to be determined. Here, we tested whether GLP-1RA treatment affects circulating NAE levels and whether NAEs may predict the efficacy of GLP-1RA treatment in humans with obesity undergoing weight loss maintenance. Materials and methods: We profiled plasma levels of NAEs in participants with obesity undergoing weight loss maintenance with (n = 23)/or without (n = 20) treatment with the GLP-1RA liraglutide. NAE levels were measured at three different time points: before the start of the study, at the end of the diet-induced weight loss, and after 52-weeks treatment. Linear regression analyses were used to investigate whether pharmacological responses could be predicted by NAEs levels. Results: Liraglutide treatment reduced plasma concentrations of the NAE and oleoyl-ethanolamide (OEA), without altering arachidonoyl-ethanolamide (AEA) levels and palmitoyl-ethanolamide (PEA) levels. High pre-treatment levels of OEA were predictive of superior compound-mediated effects on fasting insulin and triglyceride levels. High pre-treatment PEA and AEA levels were also predictive of superior Liraglutide-mediated effects on triglyceride levels. Conclusions: Our data suggests that specific NAEs such as OEA and AEA are promising biomarkers of GLP-1RA metabolic efficacy in humans with obesity during weight loss maintenance. Plasma profiling of EC-related molecules may be a promising strategy to tailor GLP-1R-based therapies to individual needs in obesity and diabetes management. © 2023, The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE). | |
dc.language.iso | EN | en_US |
dc.subject.en | Endocannabinoid-related molecules | |
dc.subject.en | Endocannabinoids | |
dc.subject.en | GLP-1R agonist | |
dc.subject.en | Obesity | |
dc.title.en | Endocannabinoid-related molecules predict the metabolic efficacy of GLP-1 receptor agonism in humans with obesity | |
dc.title.alternative | J Endocrinol Invest | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1007/s40618-023-02228-8 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
bordeaux.journal | Journal of Endocrinological Investigation | en_US |
bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.team | Physiopathologie de l'équilibre énergétique et obésité | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.identifier | hal-04426376 | |
hal.version | 1 | |
hal.date.transferred | 2024-01-30T13:13:07Z | |
hal.popular | non | en_US |
hal.audience | Internationale | en_US |
hal.export | true | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Endocrinological%20Investigation&rft.date=2023-11-04&rft.au=MATIAS,%20Isabelle&LEHMANN,%20E.W.&ZIZZARI,%20Philippe&BYBERG,%20Sarah&COTA,%20Daniela&rft.genre=article |
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