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A Bayesian framework for estimating parameters of a generic toxicokinetic model for the bioaccumulation of organic chemicals by benthic invertebrates: Proof of concept with PCB153 and two freshwater species

dc.rights.licenseopenen_US
dc.contributor.authorRATIER, Aude
hal.structure.identifierModélisation et écotoxicologie prédictives [LBBE]
dc.contributor.authorLOPES, Christelle
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorLABADIE, Pierre
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorBUDZINSKI, Hélène
ORCID: 0000-0003-1028-9154
IDREF: 070478090
hal.structure.identifierRiverLy - Fonctionnement des hydrosystèmes
dc.contributor.authorDELORME, Nicolas
hal.structure.identifierMilieux aquatiques, écologie et pollutions [UR MALY]
dc.contributor.authorQUEAU, Herve
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorPELUHET, Laurent
hal.structure.identifierMilieux aquatiques, écologie et pollutions [UR MALY]
dc.contributor.authorGEFFARD, Olivier
hal.structure.identifierBiologie des écosystèmes aquatiques [UR BELY]
dc.contributor.authorBABUT, Marc
dc.date.accessioned2024-01-30T08:37:35Z
dc.date.available2024-01-30T08:37:35Z
dc.date.issued2019-09
dc.identifier.issn0147-6513en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/187620
dc.description.abstractEnToxicokinetic (TK) models are relevant and widely used to predict chemical concentrations in biological organisms. The importance of dietary uptake for aquatic invertebrates has been increasingly assessed in recent years. However, the model parameters are estimated on limited specific laboratory data sets that are bounded by several uncertainties. The aim of this study was to implement a Bayesian framework for simultaneously estimating the parameters of a generic TK model for benthic invertebrate species from all data collected. We illustrate our approach on the bioaccumulation of PCB153 by two species with different life traits and therefore exposure routes: Chironomus riparius larvae exposed to spiked sediment for 7 days and Gammarus fossarum exposed to spiked sediment and/or leaves for 7 days and then transferred to a clean media for 7 more days. The TK models assuming first-order kinetics were fitted to the data using Bayesian inference. The median model predictions and their 95% credibility intervals showed that the model fit the data well. From a methodological point of view, this paper illustrates that simultaneously estimating all model parameters from all available data by Bayesian inference, while considering the correlation between parameters and different types of data, is a real added value for TK modeling. Moreover, we demonstrated the ability of a generic TK model considering uptake and elimination routes as modules to add according to the availability of the data measured. From an ecotoxicological point of view, we show differences in PCB153 bioaccumulation between chironomids and gammarids, explained by the different life traits of these two organisms.
dc.language.isoENen_US
dc.title.enA Bayesian framework for estimating parameters of a generic toxicokinetic model for the bioaccumulation of organic chemicals by benthic invertebrates: Proof of concept with PCB153 and two freshwater species
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.ecoenv.2019.04.080en_US
dc.subject.halSciences de l'environnementen_US
bordeaux.journalEcotoxicology and Environmental Safetyen_US
bordeaux.page33-42en_US
bordeaux.volume180en_US
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamLPTCen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-02145836
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Ecotoxicology%20and%20Environmental%20Safety&rft.date=2019-09&rft.volume=180&rft.spage=33-42&rft.epage=33-42&rft.eissn=0147-6513&rft.issn=0147-6513&rft.au=RATIER,%20Aude&LOPES,%20Christelle&LABADIE,%20Pierre&BUDZINSKI,%20H%C3%A9l%C3%A8ne&DELORME,%20Nicolas&rft.genre=article


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