Afficher la notice abrégée

Central Regulation of Brown Fat Thermogenesis in Response to Saturated or Unsaturated Long-Chain Fatty Acids

dc.rights.licenseopenen_US
hal.structure.identifierUniversitat Internacional de Catalunya [Barcelona] [UIC]
dc.contributor.authorFOSCH, Anna
hal.structure.identifierUniversitat Internacional de Catalunya [Barcelona] [UIC]
dc.contributor.authorRODRIGUEZ-GARCIA, Maria
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMIRALPEIX, Cristina
hal.structure.identifierUniversitat Internacional de Catalunya [Barcelona] [UIC]
dc.contributor.authorZAGMUTT, Sebastián
hal.structure.identifierUniversitat Internacional de Catalunya [Barcelona] [UIC]
dc.contributor.authorLARRAÑAGA, Maite
hal.structure.identifierUniversitat Internacional de Catalunya [Barcelona] [UIC]
dc.contributor.authorREGUERA, Ana Cristina
hal.structure.identifierUniversitat Internacional de Catalunya [Barcelona] [UIC]
dc.contributor.authorGARCIA-CHICA, Jesus
hal.structure.identifierUniversitat de Barcelona [UB]
dc.contributor.authorHERRERO, Laura
hal.structure.identifierUniversitat de Barcelona [UB]
dc.contributor.authorSERRA, Dolors
hal.structure.identifierUniversitat Internacional de Catalunya [Barcelona] [UIC]
dc.contributor.authorCASALS, Nuria
hal.structure.identifierUniversitat Internacional de Catalunya [Barcelona] [UIC]
dc.contributor.authorRODRIGUEZ-RODRIGUEZ, Rosalia
dc.date.accessioned2024-01-26T14:04:05Z
dc.date.available2024-01-26T14:04:05Z
dc.date.issued2023-01-15
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/187559
dc.description.abstractEnSensing of long-chain fatty acids (LCFA) in the hypothalamus modulates energy balance, and its disruption leads to obesity. To date, the effects of saturated or unsaturated LCFA on hypothalamic-brown adipose tissue (BAT) axis and the underlying mechanisms have remained largely unclear. Our aim was to characterize the main molecular pathways involved in the hypothalamic regulation of BAT thermogenesis in response to LCFA with different lengths and degrees of saturation. One-week administration of high-fat diet enriched in monounsaturated FA led to higher BAT thermogenesis compared to a saturated FA-enriched diet. Intracerebroventricular infusion of oleic and linoleic acids upregulated thermogenesis markers and temperature in brown fat of mice, and triggered neuronal activation of paraventricular (PaV), ventromedial (VMH) and arcuate (ARC) hypothalamic nuclei, which was not found with saturated FAs. The neuron-specific protein carnitine palmitoyltransferase 1-C (CPT1C) was a crucial effector of oleic acid since the FA action was blunted in CPT1C-KO mice. Moreover, changes in the AMPK/ACC/malonyl-CoA pathway and fatty acid synthase expression were evoked by oleic acid. Altogether, central infusion of unsaturated but not saturated LCFA increases BAT thermogenesis through CPT1C-mediated sensing of FA metabolism shift, which in turn drive melanocortin system activation. These findings add new insight into neuronal circuitries activated by LCFA to drive thermogenesis. © 2023 by the authors.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enLong-chain fatty acids
dc.subject.enHypothalamus
dc.subject.enThermogenesis
dc.subject.enBrown adipose tissue
dc.subject.enCPT1C
dc.subject.enObesity
dc.title.enCentral Regulation of Brown Fat Thermogenesis in Response to Saturated or Unsaturated Long-Chain Fatty Acids
dc.title.alternativeInt J Mol Scien_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/ijms24021697en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed36675212en_US
bordeaux.journalInternational Journal of Molecular Sciencesen_US
bordeaux.page1697en_US
bordeaux.volume24en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPhysiopathologie de l'équilibre énergétique et obésitéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstituto de Salud Carlos IIIen_US
bordeaux.identifier.funderIDMinisterio de Ciencia e Innovaciónen_US
hal.identifierhal-04419832
hal.version1
hal.date.transferred2024-01-26T14:04:09Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International%20Journal%20of%20Molecular%20Sciences&rft.date=2023-01-15&rft.volume=24&rft.issue=2&rft.spage=1697&rft.epage=1697&rft.au=FOSCH,%20Anna&RODRIGUEZ-GARCIA,%20Maria&MIRALPEIX,%20Cristina&ZAGMUTT,%20Sebasti%C3%A1n&LARRA%C3%91AGA,%20Maite&rft.genre=article


Fichier(s) constituant ce document

Thumbnail
Nom:
MAGENDIE_ IntJMolSci_2023_Fosch.pdf
Taille:
2.778Mo
Format:
PDF
Voir/Ouvrir
Thumbnail
Nom:
license_rdf
Taille:
914octets
Format:
application/rdf+xml
Voir/Ouvrir

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée