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Metastatic osteosarcoma, patterns of care and outcomes of patients in a real-life setting: The Metabone national observational study

dc.rights.licenseopenen_US
dc.contributor.authorREICH, M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDINART, Derek
dc.contributor.authorBELLIO, H.
dc.contributor.authorBERCHOUD, J.
dc.contributor.authorJEAN-DENIS, M.
dc.contributor.authorBONNEAU, M.
dc.contributor.authorWINTER, S.
dc.contributor.authorLARROQUETTE, Mathieu
dc.contributor.authorDUONG, R.
dc.contributor.authorNANNINI, S.
dc.contributor.authorGANTZER, J.
dc.contributor.authorNARCISO, B.
dc.contributor.authorPIPERNO-NEUMANN, S.
dc.contributor.authorVALENTIN, T.
dc.contributor.authorBRAHMI, M.
dc.contributor.authorBOMPAS, E.
dc.contributor.authorLE CESNE, A.
dc.contributor.authorROUQUETTE, P. B.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBELLERA, Carine
dc.contributor.authorTOULMONDE, Maud
dc.date.accessioned2024-01-22T15:50:10Z
dc.date.available2024-01-22T15:50:10Z
dc.date.issued2023-10
dc.date.conference2023-10-20
dc.identifier.issn0923-7534en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/187382
dc.description.abstractEnBackground: Metastatic osteosarcoma (MOS) has a poor prognosis, and treatment options are scarce in this rare disease. Large observational studies are needed to improve patients (pts) care and help designing future clinical trials. Methods: Treatment characteristics, outcomes, and prognostic factors of pts > 12 year-old treated for a MOS in 10 French centers from 2008 to 2018 and included in the prospective database of the French Sarcoma Group were analyzed. The primary objective was to describe treatment modalities of pts with MOS in a real-life setting, including systemic treatment (ST) regimen, access to clinical trials (CT) and locoregional (LR) procedures. Secondary objectives were to assess pts outcome in terms of time to next treatment (TNT), progression free survival (PFS) and overall survival (OS) for each line of ST, as well as the impact of CT access and LR procedures on TNT, PFS and OS in the metastatic setting. Results: 262 pts with MOS were included, 86 pts were metastatic from diagnosis, 176 pts had a metastatic relapse. Median follow-up was 59.7 months [51.3; 68.4]. Median age was 26 years (12-85), 48 (18.3%) pts were < 18 year old at metastasis diagnostic. Main histology was conventional OS (60.3%) and main primary location was inferior limb (60.3%). 227 (86.6%) pts received ST in the metastatic setting, with a median of 2 lines (IQR 1-3). 101 (38.5%) pts received more than 2 lines. 153 (58.4%) of pts underwent LR procedure for metastasis, including surgery (49.0%), radiation therapy (41.8%) or radiological procedures (13.1%); 46 (30.1%) pts had multiple procedures. Median OS from metastasis diagnosis was 21.5 months [95%CI 18.9-27.0]. Median TNT was 4.9 months [95%CI 4.3-5.7] for 1rst line, 5.6 months [95%CI 4.6-6.3] for 2nd line and 3.9 months [95%CI 3.5-5.1] and 2.9 months [95%CI 1.8-4.2] for 3rd and 4rth lines. 56 (24.7%) pts were included in a CT at least once in the metastatic setting, 29 in 1rst line, 27 in 2nd line and 15 in 3rd line. Conclusions: This large multicentric observational study details real-world data on patterns of treatments for pts with MOS in France. Detailed ST regimens used, median TNT, PFS and OS according to line and ST regimen as well as factors associated with TNT, PFS and OS will be presented at the meeting. Legal entity responsible for the study: Institut Bergonie. Funding: This study received a funding from Bayer and a grant from INCA. Disclosure: All authors have declared no conflicts of interest.
dc.language.isoENen_US
dc.title.enMetastatic osteosarcoma, patterns of care and outcomes of patients in a real-life setting: The Metabone national observational study
dc.typeCommunication dans un congrèsen_US
dc.identifier.doi10.1016/j.annonc.2023.09.1200en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
bordeaux.pageS1053-S1053en_US
bordeaux.volume34en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issuesupplement 2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.conference.titleESMO Congress 2023en_US
bordeaux.countryesen_US
bordeaux.title.proceedingAbstract Book of the ESMO Congress 2023, 20 - 24 October 2023en_US
bordeaux.teamEPICENE_BPHen_US
bordeaux.conference.cityMadriden_US
bordeaux.identifier.funderIDInstitut National Du Canceren_US
hal.identifierhal-04410484
hal.version1
hal.date.transferred2024-01-22T15:50:12Z
hal.invitedouien_US
hal.proceedingsouien_US
hal.conference.organizerEuropean Society For Medical Oncologyen_US
hal.conference.end2023-10-24
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.date=2023-10&amp;rft.volume=34&amp;rft.issue=supplement%202&amp;rft.spage=S1053-S1053&amp;rft.epage=S1053-S1053&amp;rft.eissn=0923-7534&amp;rft.issn=0923-7534&amp;rft.au=REICH,%20M.&amp;DINART,%20Derek&amp;BELLIO,%20H.&amp;BERCHOUD,%20J.&amp;JEAN-DENIS,%20M.&amp;rft.genre=unknown


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