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Left Ventricular Abnormal Substrate in Brugada Syndrome

dc.rights.licenseopenen_US
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorCHENITI, Ghassen
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorHAISSAGUERRE, Michel
dc.contributor.authorDINA, Christian
dc.contributor.authorKAMAKURA, Tsukasa
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorDUCHATEAU, Josselin
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorSACHER, Frederic
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorRACINE, Hugo-Pierre
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorSURGET, Elodie
dc.contributor.authorSIMONET, Floriane
dc.contributor.authorGOURRAUD, Jean-Baptiste
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorSRIDI, Soumaya
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorCOCHET, Hubert
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorANDRE, Clementine
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBOUYER, Benjamin
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorCHAUVEL, Remi
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorTIXIER, Romain
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorDERVAL, Nicolas
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorPAMBRUN, Thomas
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorDUBOIS, Remi
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorJAIS, Pierre
dc.contributor.authorNADEMANEE, Koonlawee
dc.contributor.authorREDON, Richard
dc.contributor.authorSCHOTT, Jean-Jacques
dc.contributor.authorPROBST, Vincent
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorHOCINI, Meleze
dc.contributor.authorBARC, Julien
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorBERNUS, Olivier
dc.date.accessioned2024-01-22T08:10:27Z
dc.date.available2024-01-22T08:10:27Z
dc.date.issued2023-10
dc.identifier.issn2405-5018en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/187357
dc.description.abstractEnBackgroundSlow-conductive structural abnormalities located in the epicardium of the right ventricle (RV) underlie Brugada syndrome (BrS). The extent of such substrate in the left ventricle (LV) has not been investigated.Objectives This study sought to characterize the extent of epicardial substrate abnormalities in BrS.Methods We evaluated 22 consecutive patients (mean age 46 +/- 11 years, 21 male) referred for recurrent ventricular arrhythmias (mean 10 +/- 13 episodes) in the setting of BrS. The patients underwent clinical investigations and wide genetic screening to identify SCN5A mutations and common risk variants. High-density biventricular epicardial mapping was performed to detect prolonged (>70 ms) fragmented electrograms, indicating abnormal substrate area.Results All patients presented with abnormal substrate in the epicardial anterior RV (27 +/- 11 cm(2)). Abnormal substrate was also identified on the LV epicardium in 10 patients (45%), 9 at baseline and 1 after ajmaline infusion, covering 15 +/- 11 cm(2). Of these, 4 had severe LV fascicular blocks. Patients with LV substrate had a longer history of arrhythmia (11.4 +/- 6.7 years vs 4.3 +/- 4.3 years; P = 0.003), longer PR (217 +/- 24 ms vs 171 +/- 14 ms; P < 0.001) and HV (60 +/- 12 ms vs 46 +/- 5 ms; P = 0.005) intervals, and abnormal substrate also extending into the inferior RV (100% vs 33%; P = 0.001). SCN5A mutation was present in 70% of patients with LV substrate (vs 25%; P = 0.035). SCN5A BrS patients with recurrent ventricular arrhythmias present a higher polygenic risk score compared with a nonselected BrS population (median of differences: -0.86; 95% CI: -1.48 to -0.27; P = 0.02).Conclusions A subset of patients with BrS present an abnormal substrate extending onto the LV epicardium and inferior RV that is associated with SCN5A mutations and multigenic variants.
dc.description.sponsorshipL'Institut de Rythmologie et modélisation Cardiaque - ANR-10-IAHU-0004en_US
dc.language.isoENen_US
dc.subject.enBrugada syndrome
dc.subject.enSCN5A mutation
dc.subject.enVentricular fibrillation
dc.title.enLeft Ventricular Abnormal Substrate in Brugada Syndrome
dc.title.alternativeJACC Clin Electrophysiolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jacep.2023.05.039en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37480873en_US
bordeaux.journalJACC: Clinical Electrophysiologyen_US
bordeaux.page2041-2051en_US
bordeaux.volume9en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue10en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamAHEAD_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04408764
hal.version1
hal.date.transferred2024-01-22T08:10:31Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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