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dc.rights.licenseopenen_US
hal.structure.identifierUniversity of California [San Diego] [UC San Diego]
dc.contributor.authorDE GUGLIELMO, Giordano
hal.structure.identifierUniversity of California [San Diego] [UC San Diego]
dc.contributor.authorSIMPSON, Sierra
hal.structure.identifierPurdue University [West Lafayette]
dc.contributor.authorKIMBROUGH, Adam
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCONLISK, Dana
hal.structure.identifierUniversity of California [San Diego] [UC San Diego]
dc.contributor.authorBAKER, Robert
hal.structure.identifierUniversity of California [San Diego] [UC San Diego]
dc.contributor.authorCANTOR, Maxwell
hal.structure.identifierUniversity of California [San Diego] [UC San Diego]
dc.contributor.authorKALLUPI, Marsida
hal.structure.identifierUniversity of California [San Diego] [UC San Diego]
dc.contributor.authorGEORGE, Olivier
dc.date.accessioned2024-01-18T14:46:02Z
dc.date.available2024-01-18T14:46:02Z
dc.date.issued2023-01-01
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/187337
dc.description.abstractEnA major limitation of the most widely used current animal models of alcohol dependence is that they use forced exposure to ethanol including ethanol-containing liquid diet and chronic intermittent ethanol (CIE) vapor to produce clinically relevant blood alcohol levels (BAL) and addiction-like behaviors. We recently developed a novel animal model of voluntary induction of alcohol dependence using ethanol vapor self-administration (EVSA). However, it is unknown whether EVSA leads to an escalation of alcohol drinking per se, and whether such escalation is associated with neuroadaptations in brain regions related to stress, reward, and habit. To address these issues, we compared the levels of alcohol drinking during withdrawal between rats passively exposed to alcohol (CIE) or voluntarily exposed to EVSA and measured the number of Fos+ neurons during acute withdrawal (16 h) in key brain regions important for stress, reward, and habit-related processes. CIE and EVSA rats exhibited similar BAL and similar escalation of alcohol drinking and motivation for alcohol during withdrawal. Acute withdrawal from EVSA and CIE recruited a similar number of Fos+ neurons in the Central Amygdala (CeA), however, acute withdrawal from EVSA recruited a higher number of Fos+ neurons in every other brain region analyzed compared to acute withdrawal from CIE. In summary, while the behavioral measures of alcohol dependence between the voluntary (EVSA) and passive (CIE) model were similar, the recruitment of neuronal ensembles during acute withdrawal was very different. The EVSA model may be particularly useful to unveil the neuronal networks and pharmacology responsible for the voluntary induction and maintenance of alcohol dependence and may improve translational studies by providing preclinical researchers with an animal model that highlights the volitional aspects of alcohol use disorder. © 2022 The Authors
dc.language.isoENen_US
dc.subject.enAdult
dc.subject.enAlcohol consumption
dc.subject.enAlcoholism
dc.subject.enAnimal experiment
dc.subject.enAnimal model
dc.subject.enArticle
dc.subject.enBrain region
dc.subject.enCentral nucleus (amygdala)
dc.subject.enCorpus striatum
dc.subject.enDrinking behavior
dc.subject.enFunctional connectivity
dc.subject.enHabit
dc.subject.enHippocampus
dc.subject.enImmunohistochemistry
dc.subject.enMale
dc.subject.enNerve cell
dc.subject.enNerve cell network
dc.subject.enNonhuman
dc.subject.enNucleus accumbens
dc.subject.enPeriaqueductal gray matter
dc.subject.enPhysiological stress
dc.subject.enPosttraumatic stress disorder
dc.subject.enPrefrontal cortex
dc.subject.enQuantitative analysis
dc.subject.enRat
dc.subject.enReward
dc.subject.enVapor
dc.subject.enAlcohol blood level
dc.subject.enAnimal
dc.subject.enCentral nucleus (amygdala)
dc.subject.enDisease model
dc.subject.enHabit
dc.subject.enReward
dc.title.enVoluntary and forced exposure to ethanol vapor produces similar escalation of alcohol drinking but differential recruitment of brain regions related to stress, habit, and reward in male rats
dc.title.alternativeNeuropharmacologyen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.neuropharm.2022.109309en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed36334765en_US
bordeaux.journalNeuropharmacologyen_US
bordeaux.volume222en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPsychobiologie de la vulnérabilité à l'addiction aux droguesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDNational Institute on Alcohol Abuse and Alcoholismen_US
bordeaux.identifier.funderIDBrain and Behavior Research Foundationen_US
hal.identifierhal-04403498
hal.version1
hal.date.transferred2024-01-18T14:46:06Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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