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Improving the decision to switch from first- to second-line therapy in multiple sclerosis: A dynamic scoring system.

dc.rights.licenseopenen_US
dc.contributor.authorSABATHÉ, Camille
dc.contributor.authorCASEY, Romain
dc.contributor.authorVUKUSIC, Sandra
dc.contributor.authorLERAY, Emmanuelle
dc.contributor.authorMATHEY, Guillaume
dc.contributor.authorDE SÈZE, Jérôme
dc.contributor.authorCIRON, Jonathan
dc.contributor.authorWIERTLEWSKI, Sandrine
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorRUET, Aurélie
dc.contributor.authorPELLETIER, Jean
dc.contributor.authorZÉPHIR, Hélène
dc.contributor.authorMICHEL, Laure
dc.contributor.authorLEBRUN-FRENAY, Christine
dc.contributor.authorMOISSET, Xavier
dc.contributor.authorTHOUVENOT, Eric
dc.contributor.authorCAMDESSANCHÉ, Jean-Philippe
dc.contributor.authorBAKCHINE, Serge
dc.contributor.authorSTANKOFF, Bruno
dc.contributor.authorAL KHEDR, Abdullatif
dc.contributor.authorCABRE, Philippe
dc.contributor.authorMAILLART, Elisabeth
dc.contributor.authorBERGER, Eric
dc.contributor.authorHEINZLEF, Olivier
dc.contributor.authorHANKIEWICZ, Karolina
dc.contributor.authorMOREAU, Thibault
dc.contributor.authorGOUT, Olivier
dc.contributor.authorBOURRE, Bertrand
dc.contributor.authorWAHAB, Abir
dc.contributor.authorLABAUGE, Pierre
dc.contributor.authorMONTCUQUET, Alexis
dc.contributor.authorDEFER, Gilles
dc.contributor.authorMAUROUSSET, Aude
dc.contributor.authorMAUBEUGE, Nicolas
dc.contributor.authorDIMITRI BOULOS, Dalia
dc.contributor.authorBEN NASR, Haïfa
dc.contributor.authorNIFLE, Chantal
dc.contributor.authorCASEZ, Olivier
dc.contributor.authorLAPLAUD, David-Axel
dc.contributor.authorFOUCHER, Yohann
dc.date.accessioned2024-01-08T13:54:39Z
dc.date.available2024-01-08T13:54:39Z
dc.date.issued2023-02-01
dc.identifier.issn1477-0970en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/186942
dc.description.abstractEnIn relapsing-remitting multiple sclerosis (RRMS), early identification of suboptimal responders can prevent disability progression. We aimed to develop and validate a dynamic score to guide the early decision to switch from first- to second-line therapy. Using time-dependent propensity scores (PS) from a French cohort of 12,823 patients with RRMS, we constructed one training and two validation PS-matched cohorts to compare the switched patients to second-line treatment and the maintained patients. We used a frailty Cox model for predicting individual hazard ratios (iHRs). From the validation PS-matched cohort of 348 independent patients with iHR ⩽ 0.69, we reported the 5-year relapse-free survival at 0.14 (95% confidence interval (CI) 0.09-0.22) for the waiting group and 0.40 (95% CI 0.32-0.51) for the switched group. From the validation PS-matched cohort of 518 independent patients with iHR > 0.69, these values were 0.37 (95% CI 0.30-0.46) and 0.44 (95% CI 0.37-0.52), respectively. By using the proposed dynamic score, we estimated that at least one-third of patients could benefit from an earlier switch to prevent relapse.
dc.language.isoENen_US
dc.subjectEpidemiology
dc.subjectSecond-line treatment
dc.subjectTreatment response
dc.subject.enMultiple Sclerosis
dc.title.enImproving the decision to switch from first- to second-line therapy in multiple sclerosis: A dynamic scoring system.
dc.title.alternativeMult Scleren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1177/13524585221139156en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed36515394en_US
bordeaux.journalMultiple Sclerosis Journalen_US
bordeaux.page236-247en_US
bordeaux.volume29en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamRelations glie-neuroneen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
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