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Mitochondria-targeted melatonin photorelease supports the presence of melatonin MT1 receptors in mitochondria inhibiting respiration

dc.rights.licenseopenen_US
hal.structure.identifierInstitut Cochin [IC UM3 (UMR 8104 / U1016)]
dc.contributor.authorSOMALO-BARRANCO, Gloria
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorPAGANO ZOTTOLA, Antonio
hal.structure.identifierInstitut Cochin [IC UM3 (UMR 8104 / U1016)]
dc.contributor.authorABDULRAHMAN, Abdulrasheed
hal.structure.identifierInstitut Cochin [IC UM3 (UMR 8104 / U1016)]
dc.contributor.authorEL ZEIN, Rami
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCANNICH, Astrid
hal.structure.identifierLaboratory of Medicinal Chemistry, Institute for Advanced Chemistry of Catalonia [MCS (IQAC-CSIC)]
dc.contributor.authorMUÑOZ, Lourdes
hal.structure.identifierLaboratory of Medicinal Chemistry, Institute for Advanced Chemistry of Catalonia [MCS (IQAC-CSIC)]
dc.contributor.authorSERRA, Carme
hal.structure.identifierInstitut Cochin [IC UM3 (UMR 8104 / U1016)]
dc.contributor.authorOISHI, Atsuro
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMARSICANO, Giovanni
hal.structure.identifierInstitut Cochin [IC UM3 (UMR 8104 / U1016)]
dc.contributor.authorMASRI, Bernard
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorBELLOCCHIO, Luigi
hal.structure.identifierLaboratory of Medicinal Chemistry, Institute for Advanced Chemistry of Catalonia [MCS (IQAC-CSIC)]
dc.contributor.authorLLEBARIA, Amadeu
hal.structure.identifierInstitut Cochin [IC UM3 (UMR 8104 / U1016)]
dc.contributor.authorJOCKERS, Ralf
dc.date.accessioned2024-01-04T16:51:23Z
dc.date.available2024-01-04T16:51:23Z
dc.date.issued2023-08-17
dc.identifier.issn2451-9456en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/186893
dc.description.abstractEnThe presence of signaling-competent G protein-coupled receptors in intracellular compartments is increasinglyrecognized. Recently, the presence of Gi/o protein-coupled melatonin MT1 receptors in mitochondriahas been revealed, in addition to the plasma membrane. Melatonin is highly cell permeant, activating plasmamembrane and mitochondrial receptors equally. Here, we present MCS-1145, a melatonin derivative bearinga triphenylphosphonium cation for specific mitochondrial targeting and a photocleavable o-nitrobenzylgroup releasing melatonin upon illumination. MCS-1145 displayed low affinity for MT1 and MT2 but spontaneouslyaccumulated in mitochondria, where it was resistant to washout. Uncaged MCS-1145 and exogenousmelatonin recruited b-arrestin 2 toMT1 in mitochondria and inhibited oxygen consumption inmitochondriaisolated from HEK293 cells only when expressing MT1 and from mouse cerebellum of WT mice but notfrom MT1-knockout mice. Overall, we developed the first mitochondria-targeted photoactivatable melatoninligand and demonstrate that melatonin inhibits mitochondrial respiration through mitochondrial MT1receptors.
dc.language.isoENen_US
dc.subject.enMelatonin
dc.subject.enMelatonin receptors
dc.subject.enMitochondria-targeted caged melatonin ligand
dc.subject.enPhotopharmacology
dc.subject.enMitochondrial respiration
dc.title.enMitochondria-targeted melatonin photorelease supports the presence of melatonin MT1 receptors in mitochondria inhibiting respiration
dc.title.alternativeCell Chem Biolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.chembiol.2023.07.009en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed37572668en_US
bordeaux.journalCell Chemical Biologyen_US
bordeaux.page920-932en_US
bordeaux.volume30en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue8en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEndocannabinoïdes et Neuroadaptationen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04273174
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cell%20Chemical%20Biology&rft.date=2023-08-17&rft.volume=30&rft.issue=8&rft.spage=920-932&rft.epage=920-932&rft.eissn=2451-9456&rft.issn=2451-9456&rft.au=SOMALO-BARRANCO,%20Gloria&PAGANO%20ZOTTOLA,%20Antonio&ABDULRAHMAN,%20Abdulrasheed&EL%20ZEIN,%20Rami&CANNICH,%20Astrid&rft.genre=article


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