Mostrar el registro sencillo del ítem

Serum vitamins and retinal nerve fiber layer changes on SD-OCT: the Alienor study

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMERLE, Benedicte
ORCID: 0000-0003-1332-0954
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorROUGIER, Marie-Benedicte
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFEART-COURET, Catherine
ORCID: 0000-0002-7959-1610
IDREF: 08195848X
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLE GOFF, Melanie
ORCID: 0000-0003-2848-6287
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGAYRAUD, Laure
ORCID: 0000-0002-4381-7980
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELYFER, Marie-Noelle
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSCHWEITZER, Cedric
ORCID: 0000-0002-2162-9479
IDREF: 133631583
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELCOURT, Cecile
ORCID: 0000-0002-2099-0481
IDREF: 035105291
dc.date.accessioned2023-12-20T14:39:58Z
dc.date.available2023-12-20T14:39:58Z
dc.date.issued2023-06
dc.date.conference2023-04-23
dc.identifier.issn0146-0404en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/186755
dc.description.abstractEnPurpose : Glaucoma, a multifactorial neurodegenerative disease, characterized by a progressive loss of retinal ganglion cells and a progressive thinning of the retinal nerve fiber layer (RNFL) on optical coherence tomography (OCT). Vitamins B6, B9 and B12 may contribute to retinal vascular diseases and optic neuropathies through their contribution to the homeostasis of homocysteine levels. Vitamins A, D and E may also be important for the protection of optic nerve due to their strong antioxidant properties. There are few epidemiological studies on this emerging topic. Thus, the aim of our study was to investigate the relationship between serum vitamins A, D, E, B6, B9, B12 and longitudinal changes in RNFL thickness in the Alienor study. Methods : The Alienor study is an ongoing population-based cohort of 963 older residents of Bordeaux (France) followed since 2006. RNFL thickness was measured with spectral domain-optical coherence tomography (SD-OCT) every 2 years over an 8-year period. Serum vitamins A, D, E, B6, B9 and B12 were measured at baseline from fasting blood sample. Linear mixed models were used to assess the association between serum vitamin levels and RNFL changes over time, adjusted for age, gender, axial length, family history of glaucoma, alcohol consumption and vitamin D supplement use. Results : This study included 1 187 eyes (624 participants). Among all nutrients assessed, vitamins E and B9 were significantly associated with longitudinal changes in RNFL thickness. A 1-standard deviation (SD) increase of vitamin E (11 nmol/L) and of vitamin B9 (11 nmol/L) were associated with slower RNFL thinning by 0.15 µm/year (95% confidence interval (CI), 0.02-0.28, p=0.03), 0.12 µm/year (95% CI, 0.01-0.23, p=0.03), respectively. No significant association was observed for vitamins A, D, B6 and B12 with RNFL either at baseline or with longitudinal changes. Conclusions : Higher levels of vitamins E and B9 were associated with a slower RNFL thickness on SD-OCT over time, suggesting that those vitamins may contribute to the neuroprotection of the optic nerve head and may be interesting in glaucoma management.
dc.language.isoENen_US
dc.title.enSerum vitamins and retinal nerve fiber layer changes on SD-OCT: the Alienor study
dc.typeCommunication dans un congrèsen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
bordeaux.volume64en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue8en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.conference.titleThe Beauty of Diversity in Science and Nature : ARVO Annual Meetingen_US
bordeaux.countryusen_US
bordeaux.title.proceedingARVO Annual Meeting Abstracten_US
bordeaux.teamLEHA_BPHen_US
bordeaux.conference.cityNew Orleansen_US
hal.identifierhal-04356369
hal.version1
hal.date.transferred2024-05-29T08:53:42Z
hal.invitedouien_US
hal.proceedingsouien_US
hal.conference.end2023-04-27
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2023-06&rft.volume=64&rft.issue=8&rft.eissn=0146-0404&rft.issn=0146-0404&rft.au=MERLE,%20Benedicte&ROUGIER,%20Marie-Benedicte&FEART-COURET,%20Catherine&LE%20GOFF,%20Melanie&GAYRAUD,%20Laure&rft.genre=unknown


Archivos en el ítem

ArchivosTamañoFormatoVer

No hay archivos asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem