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dc.rights.licenseopenen_US
hal.structure.identifierUniversité de Bordeaux Ségalen [Bordeaux 2]
dc.contributor.authorSAGASPE, Patricia
hal.structure.identifierUniversité de Genève = University of Geneva [UNIGE]
dc.contributor.authorSCHWARTZ, Sophie
hal.structure.identifierUniversité de Genève = University of Geneva [UNIGE]
dc.contributor.authorVUILLEUMIER, Patrik
dc.date.accessioned2023-12-18T14:39:40Z
dc.date.available2023-12-18T14:39:40Z
dc.date.issued2011-04-15
dc.identifier.issn1095-9572en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/186706
dc.description.abstractEnRapid interruption of ongoing motor actions is crucial to respond to unexpected and potentially threatening situations. Yet, it remains unclear how motor inhibition interacts with emotional processes. Here we used a modified stop-signal task including an emotional component (fearful faces) to investigate whether neural circuits engaged by action suppression are modulated by task-irrelevant threat-related signals. Behavioral performance showed that reaction times were prolonged in the presence of incidental threat information, and this emotional slowing was enhanced when incorrect responses were made following stop signals. However, the speed and efficacy of voluntary inhibition was unaffected by emotion. Brain imaging data revealed that emotional cues during stop trials interacted with activity in limbic regions encompassing the basal amygdala and sublenticular extended amygdala region, as well as with the supplementary motor area (SMA). In addition, successful motor inhibition to threat signals selectively recruited a region in lateral orbitofrontal cortex, distinct from areas in inferior frontal gyrus typically associated with voluntary inhibition. Activity in primary motor cortex was lower when incorrect responses were made on stop signal trials accompanied by a fearful face, relative to neutral, in parallel with the slower response times observed behaviorally. Taken together, our findings suggest that the amygdala may not only promote protective motor reactions in emotionally-significant contexts (such as freezing or defensive behavior) but also influence the execution of ongoing actions by modulating brain circuits involved in motor control, so as to afford quick and adaptive changes in current behavior.
dc.language.isoENen_US
dc.subject.enAdolescent
dc.subject.enAdult
dc.subject.enAmygdala
dc.subject.enDecision Making
dc.subject.enFear
dc.subject.enFemale
dc.subject.enHumans
dc.subject.enMagnetic Resonance Imaging
dc.subject.enMale
dc.subject.enMovement
dc.subject.enNeural Inhibition
dc.subject.enYoung Adult
dc.subject.enFunctional MRI
dc.subject.enFrontal cortex
dc.subject.enEmotion
dc.subject.enMotor inhibition
dc.title.enFear and stop: a role for the amygdala in motor inhibition by emotional signals.
dc.title.alternativeNeuroimageen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.neuroimage.2011.01.027en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed21272655en_US
bordeaux.journalNeuroImageen_US
bordeaux.page1825-35en_US
bordeaux.volume55en_US
bordeaux.hal.laboratoriesAnciens laboratoires de l'Université de Bordeauxen_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04350966
hal.version1
hal.date.transferred2023-12-18T14:39:42Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=NeuroImage&rft.date=2011-04-15&rft.volume=55&rft.issue=4&rft.spage=1825-35&rft.epage=1825-35&rft.eissn=1095-9572&rft.issn=1095-9572&rft.au=SAGASPE,%20Patricia&SCHWARTZ,%20Sophie&VUILLEUMIER,%20Patrik&rft.genre=article


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