Plasma carotenoids and risk of depressive symptomatology in a population-based cohort of older adults
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BARDINET, Jeanne | |
| dc.contributor.author | POUCHIEU, Camille | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | CHUY, Virginie
IDREF: 234159758 | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | HELMER, Catherine | |
| dc.contributor.author | ETHEVE, Stephane | |
| dc.contributor.author | GAUDOUT, David | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SAMIERI, Cecilia | |
| dc.contributor.author | BERR, Claudine | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DELCOURT, Cecile
ORCID: 0000-0002-2099-0481 IDREF: 035105291 | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | COUGNARD-GREGOIRE, Audrey | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | FEART-COURET, Catherine
ORCID: 0000-0002-7959-1610 IDREF: 08195848X | |
| dc.date.accessioned | 2023-12-13T12:09:09Z | |
| dc.date.available | 2023-12-13T12:09:09Z | |
| dc.date.issued | 2023-10-15 | |
| dc.identifier.issn | 1573-2517 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/186594 | |
| dc.description.abstractEn | BACKGROUND: As part of a healthy diet, higher carotenoid intakes have been associated with a reduced risk of depression, mainly in adults, while prospective studies on plasma carotenoids in older adults are lacking. The aim of this study was to assess the prospective association between plasma carotenoids and the risk of Depressive Symptomatology (DS) in older adults. METHODS: The study sample was based on the Three-City cohort of adults aged 65y+ free from DS at enrollment in 1999. Plasma carotenoids were measured at baseline. DS was assessed every 2-3 years over 17 years and defined by a Center for Epidemiologic Studies-Depression Scale score ≥ 16 and/or by antidepressant use. The association between plasma carotenoids or carotenoid/lipids (cholesterol and triglycerides) ratio and the risk for DS was assessed through multiple random-effect logistic regression. RESULTS: The study sample was composed of 1010 participants (mean age 74 y (±4.9), 58 % of women) followed-up during a median time of 13.4 years. Plasma zeaxanthin and ratios of zeaxanthin/lipids, lutein+zeaxanthin/lipids and β-carotene/lipids were independently associated with a significant reduced risk of DS over time (Odds ratio (OR) = 0.81, 95 % Confidence Interval (CI) [0.67;0.99], OR = 0.79 [0.67;0.98], OR = 0.79 [0.64;0.94] and OR = 0.80 [0.66;0.97] for +1 standard deviation of each exposure respectively). LIMITATIONS: Plasma carotenoids were only available at study baseline. CONCLUSION: Focusing on circulating carotenoids and considering lipids levels, the present results suggested an association between higher levels of plasma zeaxanthin, combined lutein+zeaxanthin and β-carotene and a decreased risk of DS over time in older adults. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Cohort | |
| dc.subject.en | Depressive symptomatology | |
| dc.subject.en | Older adults | |
| dc.subject.en | Plasma carotenoids | |
| dc.subject.en | Three-City | |
| dc.title.en | Plasma carotenoids and risk of depressive symptomatology in a population-based cohort of older adults | |
| dc.title.alternative | J Affect Disord | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.jad.2023.07.076 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 37467792 | en_US |
| bordeaux.journal | Journal of Affective Disorders | en_US |
| bordeaux.page | 615-623 | en_US |
| bordeaux.volume | 339 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | ELEANOR_BPH | en_US |
| bordeaux.team | LEHA_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Sanofi | en_US |
| bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Mutuelle Générale de l'Education Nationale | en_US |
| bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
| hal.identifier | hal-04342276 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-12-13T12:09:11Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Affective%20Disorders&rft.date=2023-10-15&rft.volume=339&rft.spage=615-623&rft.epage=615-623&rft.eissn=1573-2517&rft.issn=1573-2517&rft.au=BARDINET,%20Jeanne&POUCHIEU,%20Camille&CHUY,%20Virginie&HELMER,%20Catherine&ETHEVE,%20Stephane&rft.genre=article |
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