Juvenile mild traumatic brain injury elicits distinct spatiotemporal astrocyte responses
dc.rights.license | open | en_US |
hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
dc.contributor.author | CLEMENT, Tifenn | |
hal.structure.identifier | Loma Linda University | |
dc.contributor.author | LEE, Jeong Bin | |
hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
dc.contributor.author | ICHKOVA, Aleksandra | |
hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
dc.contributor.author | RODRIGUEZ-GRANDE, Beatriz | |
hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
dc.contributor.author | FOURNIER, Marie-Line | |
hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
dc.contributor.author | AUSSUDRE, Justine | |
hal.structure.identifier | Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] [IRBA] | |
dc.contributor.author | OGIER, Michael | |
dc.contributor.author | HADDAD, Elizabeth | |
hal.structure.identifier | Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] [IRBA] | |
dc.contributor.author | CANINI, Frederic | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | KOEHL, Muriel | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | ABROUS, Nora | |
hal.structure.identifier | Loma Linda University | |
dc.contributor.author | OBENAUS, Andre | |
hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
dc.contributor.author | BADAUT, Jerome | |
dc.date.accessioned | 2023-12-07T15:40:17Z | |
dc.date.available | 2023-12-07T15:40:17Z | |
dc.date.issued | 2020-03 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/186446 | |
dc.description.abstractEn | Mild-traumatic brain injury (mTBI) represents ~80% of all emergency room visits and increases the probability of developing long-term cognitive disorders in children. To date, molecular and cellular mechanisms underlying post-mTBI cognitive dysfunction are unknown. Astrogliosis has been shown to significantly alter astrocytes' properties following brain injury, potentially leading to significant brain dysfunction. However, such alterations have never been investigated in the context of juvenile mTBI (jmTBI). A closed-head injury model was used to study jmTBI on postnatal-day 17 mice. Astrogliosis was evaluated using glial fibrillary acidic protein (GFAP), vimentin, and nestin immunolabeling in somatosensory cortex (SSC), dentate gyrus (DG), amygdala (AMY), and infralimbic area (ILA) of prefrontal cortex in both hemispheres from 1 to 30 days postinjury (dpi). In vivo T2-weighted-imaging (T2WI) and diffusion tensor imaging (DTI) were performed at 7 and 30 dpi to examine tissue level structural alterations. Increased GFAP-labeling was observed up to 30 dpi in the ipsilateral SSC, the initial site of the impact. However, vimentin and nestin expression was not perturbed by jmTBI. The morphology of GFAP positive cells was significantly altered in the SSC, DG, AMY, and ILA up to 7 dpi that some correlated with magnetic resonance imaging changes. T2WI and DTI values were significantly altered at 30 dpi within these brain regions most prominently in regions distant from the impact site. Our data show that jmTBI triggers changes in astrocytic phenotype with a distinct spatiotemporal pattern. We speculate that the presence and time course of astrogliosis may contribute to pathophysiological processes and long-term structural alterations following jmTBI. © 2019 Wiley Periodicals, Inc. | |
dc.description.sponsorship | Translational Research and Advanced Imaging Laboratory - ANR-10-LABX-0057 | en_US |
dc.description.sponsorship | Bordeaux Region Aquitaine Initiative for Neuroscience | en_US |
dc.language.iso | EN | en_US |
dc.subject.en | MRI | |
dc.subject.en | Histology | |
dc.subject.en | Neuroinflammation | |
dc.subject.en | Traumatic brain injury | |
dc.title.en | Juvenile mild traumatic brain injury elicits distinct spatiotemporal astrocyte responses | |
dc.title.alternative | Glia | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1002/glia.23736 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
dc.identifier.pubmed | 31670865 | en_US |
bordeaux.journal | Glia | en_US |
bordeaux.page | 528-542 | en_US |
bordeaux.volume | 68 | en_US |
bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
bordeaux.issue | 3 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.institution | CNRS | |
bordeaux.team | Neurogénèse et physiopathologie | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.identifier.funderID | Direction Générale de l’Armement | en_US |
hal.popular | non | en_US |
hal.audience | Internationale | en_US |
hal.export | false | |
dc.rights.cc | Pas de Licence CC | en_US |
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