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Clinical and imaging biomarkers of response to intravitreal dexamethasone implant in eyes with non-infectious uveitic macular oedema
| dc.rights.license | open | en_US |
| dc.contributor.author | CICINELLI, Maria Vittoria | |
| dc.contributor.author | GEROSOLIMA, Claudia | |
| dc.contributor.author | SCANDALE, Pierluigi | |
| dc.contributor.author | TOUHAMI, Sarah | |
| dc.contributor.author | POHLMANN, Dominika | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | GIOCANTI, Audrey | |
| dc.contributor.author | ROSENBLATT, Amir | |
| dc.contributor.author | LOEWENSTEIN, Anat | |
| dc.contributor.author | BANDELLO, Francesco | |
| dc.contributor.author | MISEROCCHI, Elisabetta | |
| dc.date.accessioned | 2023-12-06T14:10:15Z | |
| dc.date.available | 2023-12-06T14:10:15Z | |
| dc.date.issued | 2023-10-30 | |
| dc.identifier.issn | 0950-222X | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/186410 | |
| dc.description.abstractEn | OBJECTIVE: To investigate clinical and spectral-domain optical coherence tomography (SD-OCT) biomarkers correlating with pre-injection visual acuity (VA), post-injection VA, and the likelihood of macular oedema (MO) regression following dexamethasone (DEX) implant injection in non-infectious uveitic (NIU) patients. METHODS: Patient data from Uveitis Services in Milan, Paris, and Berlin were analysed. Eligible participants were NIU patients aged >18 years with MO as the primary indication for DEX treatment. SD-OCT scans and clinical data were collected at the time of DEX injection (pre-injection visit) and after 3 months (post-injection visit). Multivariable regression models, adjusted for pre-injection VA and lens status, were employed to explore associations. MO regression was defined as the absence of intraretinal/subretinal fluid at the post-injection visit. RESULTS: Our analysis comprised data from 173 DEX treatments, encompassing 103 eyes from 80 patients, with 38 eyes (37%) receiving repeated DEX injections. The absence of the ellipsoid zone (EZ) layer and disorganisation of the inner retinal layers (DRIL) were associated with worse pre- (+0.19 LogMAR, 95% CI 0.01-0.38, p = 0.06, and +0.10 LogMAR, 95% CI 0.02-0.21, p = 0.01) and post-injection VA (+0.33 LogMAR, 95% CI 0.08-0.57, p = 0.01, and +0.17 LogMAR, 95% CI 0.01-0.32, p = 0.04). EZ disruption and DRIL increased significantly (p = 0.01 and p = 0.04), and the chance of gaining ≥5 letters declined in eyes undergoing repeated DEX (p = 0.002). The rate of MO regression after each DEX was 67%. Prolonged MO duration (OR = 0.75/each year, p = 0.02) was associated with reduced likelihood of MO regression. Subretinal fluid was associated with higher rate of MO regression (OR = 6.09, p = 0.01). CONCLUSION: Integrity of the inner and outer retina is associated with better visual response to DEX. Long-standing or recurrent MO is associated with less chance of both visual and anatomic response. Timely treatment is necessary to maximise the outcomes of MO in NIU patients. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Macular oedema | |
| dc.subject.en | Non-infectious uveitis | |
| dc.subject.en | Dexamethasone implant | |
| dc.subject.en | Optical coherence tomography | |
| dc.title.en | Clinical and imaging biomarkers of response to intravitreal dexamethasone implant in eyes with non-infectious uveitic macular oedema | |
| dc.title.alternative | Eye (Lond) | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1038/s41433-023-02802-7 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 37904001 | en_US |
| bordeaux.journal | Eye | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | LEHA_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-04328544 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-12-07T09:29:13Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Eye&rft.date=2023-10-30&rft.eissn=0950-222X&rft.issn=0950-222X&rft.au=CICINELLI,%20Maria%20Vittoria&GEROSOLIMA,%20Claudia&SCANDALE,%20Pierluigi&TOUHAMI,%20Sarah&POHLMANN,%20Dominika&rft.genre=article |
