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dc.rights.licenseopenen_US
dc.contributor.authorCAVAILLES, Clemence
dc.contributor.authorLETELLIER, Noemie
dc.contributor.authorBERR, Claudine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIERI, Cecilia
dc.contributor.authorEMPANA, Jean-Philippe
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTZOURIO, Christophe
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
ORCID: 0000-0001-9482-5529
IDREF: 058586105
dc.contributor.authorBENMARHNIA, Tarik
dc.contributor.authorDAUVILLIERS, Yves
dc.contributor.authorJAUSSENT, Isabelle
dc.date.accessioned2023-12-06T13:31:44Z
dc.date.available2023-12-06T13:31:44Z
dc.date.issued2023-10-11
dc.identifier.issn1365-2869en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/186409
dc.description.abstractEnMany studies suggest a relationship between excessive daytime sleepiness (EDS) and dementia incidence, but the underlying mechanisms remain uncertain. The study aimed to investigate the role of cardiovascular burden in the relationship between EDS and dementia incidence over a 12-year follow-up in community-dwelling older adults. We performed analyses on 6171 subjects (aged ≥65 years) free of dementia and vascular disease at baseline. Participants self-reported EDS at baseline and an expert committee validated both prevalent and incident dementia. We defined cardiovascular burden by a low Cardiovascular Health score, constructed using the American Heart Association metrics, and incident vascular events. To explore the potential role of the cardiovascular burden in the relationship between EDS and dementia, we conducted mediation analyses with inverse odds ratio-weighted estimation, using multivariable-adjusted proportional hazard Cox and logistic regression models. Subjects with EDS had a higher risk of all-cause dementia (hazard ratio [HR] 1.39, 95% confidence interval [CI] 1.13-1.69) and dementia with vascular component (DVC) (HR 2.14, 95% CI 1.30-3.51), but not Alzheimer's disease (HR 1.18, 95% CI 0.93-1.51). Cardiovascular burden explained 5% (95% CI 4.1-5.2) and 11% (95% CI 9.7-11.3) of the relationship between EDS and all-cause dementia and DVC, respectively. These findings confirm that EDS may be implicated in the development of dementia and indicate a weaker than expected role of cardiovascular burden in the relationship between EDS and DVC.
dc.description.sponsorshipCOGINUT : Cognition, anti-oxydants, acides gras: approche interdisciplinaire du rôle de la nutrition dans le vieillissement du cerveau - ANR-06-PNRA-0005en_US
dc.description.sponsorshipInteraction entre la vulnérabilité génétique, la dysrégulation biologique et le stress dans la dépression du sujet âgéen_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enCardiovascular disease
dc.subject.enDementia
dc.subject.enExcessive daytime sleepiness
dc.subject.enMediation analysis
dc.subject.enOlder people
dc.title.enThe role of cardiovascular health and vascular events in the relationship between excessive daytime sleepiness and dementia risk
dc.title.alternativeJ Sleep Resen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/jsr.14053en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37822116en_US
bordeaux.journalJournal of Sleep Researchen_US
bordeaux.pagee14053en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamACTIVE_BPHen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.teamHEALTHY_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
hal.identifierhal-04326867
hal.version1
hal.date.transferred2023-12-06T13:31:46Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Sleep%20Research&rft.date=2023-10-11&rft.spage=e14053&rft.epage=e14053&rft.eissn=1365-2869&rft.issn=1365-2869&rft.au=CAVAILLES,%20Clemence&LETELLIER,%20Noemie&BERR,%20Claudine&SAMIERI,%20Cecilia&EMPANA,%20Jean-Philippe&rft.genre=article


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