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A Mediterranean Diet-Based Metabolomic Score and Cognitive Decline in Older Adults: A Case-Control Analysis Nested within the Three-City Cohort Study

dc.rights.licenseopenen_US
dc.contributor.authorTOR-ROCA, Alba
dc.contributor.authorSÁNCHEZ-PLA, Alex
dc.contributor.authorKOROSI, Aniko
dc.contributor.authorPALLÀS, Mercè
dc.contributor.authorLUCASSEN, Paul J
dc.contributor.authorCASTELLANO-ESCUDER, Pol
dc.contributor.authorAIGNER, Ludwig
dc.contributor.authorGONZÁLEZ-DOMÍNGUEZ, Raúl
dc.contributor.authorMANACH, Claudine
dc.contributor.authorCARMONA, Francisco
dc.contributor.authorVEGAS, Esteban
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFEART-COURET, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEFEVRE ARBOGAST, Sophie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorNEUFFER, Jeanne
dc.contributor.authorLEE, Hyunah
dc.contributor.authorTHURET, Sandrine
dc.contributor.authorANDRES-LACUEVA, Cristina
dc.contributor.authorSAMIERI, Cécilia
dc.contributor.authorURPI-SARDA, Mireia
dc.date.accessioned2023-11-27T14:55:10Z
dc.date.available2023-11-27T14:55:10Z
dc.date.issued2023-10-24
dc.identifier.issn1613-4133en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/186173
dc.description.abstractEnEvidence on the Mediterranean diet (MD) and age-related cognitive decline (CD) is still inconclusive partly due to self-reported dietary assessment. The aim of the current study is to develop an MD- metabolomic score (MDMS) and investigate its association with CD in community-dwelling older adults. This study includes participants from the Three-City Study from the Bordeaux (n = 418) and Dijon (n = 422) cohorts who are free of dementia at baseline. Repeated measures of cognition over 12 years are collected. An MDMS is designed based on serum biomarkers related to MD key food groups and using a targeted metabolomics platform. Associations with CD are investigated through conditional logistic regression (matched on age, sex, and education level) in both sample sets. The MDMS is found to be inversely associated with CD (odds ratio [OR] [95% confidence interval (CI)] = 0.90 [0.80-1.00]; p = 0.048) in the Bordeaux (discovery) cohort. Results are comparable in the Dijon (validation) cohort, with a trend toward significance (OR [95% CI] = 0.91 [0.83-1.01]; p = 0.084). A greater adherence to the MD, here assessed by a serum MDMS, is associated with lower odds of CD in older adults.
dc.description.sponsorshipIdentification of dietary modulators of cognitive ageing and brain plasticity and proof of concept of efficacy for preventing-reversing cognitive declineen_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAlzheimer's disease
dc.subject.enAging
dc.subject.enCognitive dysfunction
dc.subject.enCognitive impairment
dc.subject.enMetabolite
dc.title.enA Mediterranean Diet-Based Metabolomic Score and Cognitive Decline in Older Adults: A Case-Control Analysis Nested within the Three-City Cohort Study
dc.title.alternativeMol Nutr Food Resen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/mnfr.202300271en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37876144en_US
dc.description.sponsorshipEuropeA Healthy Diet for a Healthy Life - Coordination Actionen_US
bordeaux.journalMolecular Nutrition and Food Researchen_US
bordeaux.pagee2300271en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDMedical Research Councilen_US
bordeaux.identifier.funderIDInstituto de Salud Carlos IIIen_US
bordeaux.identifier.funderIDEuropean Regional Development Funden_US
bordeaux.identifier.funderIDGeneralitat de Catalunyaen_US
bordeaux.identifier.funderIDSanofien_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDCaisse nationale de l'Assurance Maladieen_US
bordeaux.identifier.funderIDMutuelle Générale de l'Education Nationaleen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDFondation de Franceen_US
bordeaux.identifier.funderIDCaisse nationale de solidarité pour l'autonomieen_US
bordeaux.identifier.funderIDConseil régional de Bourgogne-Franche-Comtéen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04309990
hal.version1
hal.date.transferred2023-11-27T14:55:14Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
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