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Multi-omics quantitative data of tomato fruit unveils regulation modes of least variable metabolites

hal.structure.identifierBiologie du fruit et pathologie [BFP]
hal.structure.identifierPlateforme Bordeaux Metabolome
dc.contributor.authorMOING, Annick
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorBERTON, Thierry
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorROCH, Léa
hal.structure.identifierBiologie du fruit et pathologie [BFP]
hal.structure.identifierLaboratoire de Recherche en Sciences Végétales [LRSV]
dc.contributor.authorDIARRASSOUBA, Salimata
hal.structure.identifierUnité de recherche Mycologie et Sécurité des Aliments [MycSA]
hal.structure.identifierBiologie du fruit et pathologie [BFP]
hal.structure.identifierPlateforme Bordeaux Metabolome
dc.contributor.authorBERNILLON, Stéphane
hal.structure.identifierMax Planck Institute of Molecular Plant Physiology [MPI-MP]
dc.contributor.authorARRIVAULT, Stéphanie
hal.structure.identifierBiologie du fruit et pathologie [BFP]
hal.structure.identifierBioInformatique et BioStatistiques [CIRI] [BIBS]
hal.structure.identifierPlateforme Bordeaux Metabolome
dc.contributor.authorDEBORDE, Catherine
hal.structure.identifierBiologie du fruit et pathologie [BFP]
hal.structure.identifierPlateforme Bordeaux Metabolome
dc.contributor.authorMAUCOURT, Mickaël
hal.structure.identifierPlateforme Bordeaux Metabolome
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorCABASSON, Cecile
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorBÉNARD, Camille
hal.structure.identifierBiologie du fruit et pathologie [BFP]
hal.structure.identifierPlateforme Bordeaux Metabolome
dc.contributor.authorPRIGENT, Sylvain
hal.structure.identifierBiologie du fruit et pathologie [BFP]
hal.structure.identifierPlateforme Bordeaux Metabolome
dc.contributor.authorJACOB, Daniel
hal.structure.identifierBiologie du fruit et pathologie [BFP]
hal.structure.identifierPlateforme Bordeaux Metabolome
dc.contributor.authorGIBON, Yves
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorLEMAIRE-CHAMLEY, Martine
dc.date.issued2023-07-22
dc.identifier.issn1471-2229
dc.description.abstractEnBackground The composition of ripe fruits depends on various metabolites which content evolves greatly throughout fruit development and may be influenced by the environment. The corresponding metabolism regulations have been widely described in tomato during fruit growth and ripening. However, the regulation of other metabolites that do not show large changes in content have scarcely been studied. Results We analysed the metabolites of tomato fruits collected on different trusses during fruit development, using complementary analytical strategies. We identified the 22 least variable metabolites, based on their coefficients of variation. We first verified that they had a limited functional link with the least variable proteins and transcripts. We then posited that metabolite contents could be stabilized through complex regulations and combined their data with the quantitative proteome or transcriptome data, using sparse partial-least-square analyses. This showed shared regulations between several metabolites, which interestingly remained linked to early fruit development. We also examined regulations in specific metabolites using correlations with individual proteins and transcripts, which revealed that a stable metabolite does not always correlate with proteins and transcripts of its known related pathways. Conclusions The regulation of the least variable metabolites was then interpreted regarding their roles as hubs in metabolic pathways or as signalling molecules.
dc.description.sponsorshipModélisation intégrative du fruit pour un système de sélection unifié
dc.description.sponsorshipCentre français de phénomique végétale
dc.description.sponsorshipDéveloppement d'une infrastructure française distribuée pour la métabolomique dédiée à l'innovation
dc.language.isoen
dc.publisherBioMed Central
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.enFruit
dc.subject.enLC-MS
dc.subject.enMetabolism regulation
dc.subject.enProton NMR
dc.subject.enOmics
dc.subject.enSolanum lycopersicum
dc.title.enMulti-omics quantitative data of tomato fruit unveils regulation modes of least variable metabolites
dc.typeArticle de revue
dc.identifier.doi10.1186/s12870-023-04370-0
dc.subject.halSciences du Vivant [q-bio]
dc.subject.halSciences du Vivant [q-bio]/Biologie végétale
bordeaux.journalBMC Plant Biology
bordeaux.volume23
bordeaux.issue365
bordeaux.peerReviewedoui
hal.identifierhal-04183193
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04183193v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BMC%20Plant%20Biology&rft.date=2023-07-22&rft.volume=23&rft.issue=365&rft.eissn=1471-2229&rft.issn=1471-2229&rft.au=MOING,%20Annick&BERTON,%20Thierry&ROCH,%20L%C3%A9a&DIARRASSOUBA,%20Salimata&BERNILLON,%20St%C3%A9phane&rft.genre=article


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