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Hierarchical superparamagnetic metal–organic framework nanovectors as anti-inflammatory nanomedicines

dc.rights.licenseopenen_US
hal.structure.identifierInstitut des Matériaux Poreux de Paris [IMAP ]
dc.contributor.authorZHAO, Heng
hal.structure.identifierInstitut Lavoisier de Versailles [ILV]
dc.contributor.authorSENE, Saad
hal.structure.identifierInstitut des Matériaux Poreux de Paris [IMAP ]
dc.contributor.authorMIELCAREK, Angelika
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorMIRAUX, Sylvain
hal.structure.identifierSorbonne Université [SU]
hal.structure.identifierInstitut de minéralogie, de physique des matériaux et de cosmochimie [IMPMC]
dc.contributor.authorMENGUY, Nicolas
hal.structure.identifierInstitut de Physique et Chimie des Matériaux de Strasbourg [IPCMS]
dc.contributor.authorIHIAWAKRIM, Dris
hal.structure.identifierInstitut de Physique et Chimie des Matériaux de Strasbourg [IPCMS]
dc.contributor.authorERSEN, Ovidiu
hal.structure.identifierUniversité Paris-Saclay
hal.structure.identifierGénétique Animale et Biologie Intégrative [GABI]
dc.contributor.authorPÉCHOUX, Christine
hal.structure.identifierInstitut Lavoisier de Versailles [ILV]
dc.contributor.authorGUILLOU, Nathalie
hal.structure.identifierGroupe d'Etude de la Matière Condensée [GEMAC]
dc.contributor.authorSCOLA, Joseph
hal.structure.identifierInstitut des Molécules et Matériaux du Mans [IMMM]
dc.contributor.authorGRENÈCHE, Jean-Marc
hal.structure.identifierInstitut des Matériaux Poreux de Paris [IMAP ]
dc.contributor.authorNOUAR, Farid
hal.structure.identifierInstitut Galien Paris-Saclay [IGPS]
dc.contributor.authorMURA, Simona
hal.structure.identifierMatière et Systèmes Complexes [MSC]
dc.contributor.authorCARN, Florent
hal.structure.identifierMatière et Systèmes Complexes [MSC]
dc.contributor.authorGAZEAU, Florence
hal.structure.identifierInstitut Lavoisier de Versailles [ILV]
dc.contributor.authorDUMAS, Eddy
hal.structure.identifierInstitut des Matériaux Poreux de Paris [IMAP ]
dc.contributor.authorSERRE, Christian
hal.structure.identifierInstitut Lavoisier de Versailles [ILV]
hal.structure.identifierInstitut des Matériaux Poreux de Paris [IMAP ]
dc.contributor.authorSTEUNOU, Nathalie
dc.date.accessioned2023-11-16T12:30:50Z
dc.date.available2023-11-16T12:30:50Z
dc.date.issued2023-04-05
dc.identifier.issn2050-750Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184810
dc.description.abstractEnAmong a plethora of drug nanocarriers, biocompatible nanoscale metal-organic frameworks (nanoMOFs) with a large surface area and an amphiphilic internal microenvironment have emerged as promising drug delivery platforms, mainly for cancer therapy. However, their application in biomedicine still suffers from shortcomings such as a limited chemical and/or colloidal stability and/or toxicity. Here, we report the design of a hierarchically porous nano-object (denoted as USPIO@MIL) combining a benchmark nanoMOF (that is, MIL-100(Fe)) and ultra-small superparamagnetic iron oxide (USPIO) nanoparticles (that is, maghemite) that is synthesized through a one-pot, cost-effective and environmentally friendly protocol. The synergistic coupling of the physico-chemical and functional properties of both nanoparticles confers to these nano-objects valuable features such as high colloidal stability, high biodegradability, low toxicity, high drug loading capacity as well as stimuli-responsive drug release and superparamagnetic properties. This bimodal MIL-100(Fe)/maghemite nanocarrier once loaded with anti-tumoral and anti-inflammatory drugs (doxorubicin and methotrexate) shows high anti-inflammatory and anti-tumoral activities. In addition, the USPIO@MIL nano-object exhibits excellent relaxometric properties and its applicability as an efficient contrast agent for magnetic resonance imaging is herein demonstrated. This highlights the high potential of the maghemite@MOF composite integrating the functions of imaging and therapy as a theranostic anti-inflammatory formulation.
dc.language.isoENen_US
dc.title.enHierarchical superparamagnetic metal–organic framework nanovectors as anti-inflammatory nanomedicines
dc.typeArticle de revueen_US
dc.identifier.doi10.1039/d2tb02094gen_US
dc.subject.halChimieen_US
bordeaux.journalJournal of materials chemistry‎ Ben_US
bordeaux.page3195-3211en_US
bordeaux.volume11en_US
bordeaux.hal.laboratoriesCentre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536en_US
bordeaux.issue14en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04068864
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20materials%20chemistry%E2%80%8E%20B&rft.date=2023-04-05&rft.volume=11&rft.issue=14&rft.spage=3195-3211&rft.epage=3195-3211&rft.eissn=2050-750X&rft.issn=2050-750X&rft.au=ZHAO,%20Heng&SENE,%20Saad&MIELCAREK,%20Angelika&MIRAUX,%20Sylvain&MENGUY,%20Nicolas&rft.genre=article


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