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dc.rights.licenseopenen_US
dc.contributor.authorNEVES SILVA, Sara
dc.contributor.authorAVILES VERDERA, Jordina
dc.contributor.authorTOMI-TRICOT, Raphael
dc.contributor.authorNEJI, Radhouene
dc.contributor.authorUUS, Alena
dc.contributor.authorGRIGORESCU, Irina
dc.contributor.authorWILKINSON, Thomas
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorOZENNE, Valery
dc.contributor.authorLEWIN, Alexander
dc.contributor.authorSTORY, Lisa
dc.contributor.authorDE VITA, Enrico
dc.contributor.authorRUTHERFORD, Mary
dc.contributor.authorPUSHPARAJAH, Kuberan
dc.contributor.authorHAJNAL, Jo
dc.contributor.authorHUTTER, Jana
dc.date.accessioned2023-11-16T12:05:25Z
dc.date.available2023-11-16T12:05:25Z
dc.date.issued2023-12-01
dc.identifier.issn1522-2594en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184807
dc.description.abstractEnTo improve motion robustness of functional fetal MRI scans by developing an intrinsic real-time motion correction method. MRI provides an ideal tool to characterize fetal brain development and growth. It is, however, a relatively slow imaging technique and therefore extremely susceptible to subject motion, particularly in functional MRI experiments acquiring multiple Echo-Planar-Imaging-based repetitions, for example, diffusion MRI or blood-oxygen-level-dependency MRI. A 3D UNet was trained on 125 fetal datasets to track the fetal brain position in each repetition of the scan in real time. This tracking, inserted into a Gadgetron pipeline on a clinical scanner, allows updating the position of the field of view in a modified echo-planar imaging sequence. The method was evaluated in real-time in controlled-motion phantom experiments and ten fetal MR studies (17 + 4-34 + 3 gestational weeks) at 3T. The localization network was additionally tested retrospectively on 29 low-field (0.55T) datasets. Our method achieved real-time fetal head tracking and prospective correction of the acquisition geometry. Localization performance achieved Dice scores of 84.4% and 82.3%, respectively for both the unseen 1.5T/3T and 0.55T fetal data, with values higher for cephalic fetuses and increasing with gestational age. Our technique was able to follow the fetal brain even for fetuses under 18 weeks GA in real-time at 3T and was successfully applied "offline" to new cohorts on 0.55T. Next, it will be deployed to other modalities such as fetal diffusion MRI and to cohorts of pregnant participants diagnosed with pregnancy complications, for example, pre-eclampsia and congenital heart disease.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enFemale
dc.subject.enHumans
dc.subject.enPregnancy
dc.subject.enProspective Studies
dc.subject.enRetrospective Studies
dc.subject.enMagnetic Resonance Imaging
dc.subject.enFetus
dc.subject.enBrain
dc.subject.enMotion
dc.title.enReal-time fetal brain tracking for functional fetal MRI
dc.title.alternativeMagn Reson Meden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/mrm.29803en_US
dc.subject.halSciences du Vivant [q-bio]en_US
dc.subject.halSciences de l'ingénieur [physics]en_US
dc.identifier.pubmed37465882en_US
bordeaux.journalMagnetic Resonance in Medicineen_US
bordeaux.page2306-2320en_US
bordeaux.volume90en_US
bordeaux.hal.laboratoriesCentre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536en_US
bordeaux.issue6en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDWellcome Trusten_US
bordeaux.identifier.funderIDWellcome EPSRC Centre for Medical Engineeringen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04290138
hal.version2
hal.date.transferred2023-11-18T04:48:06Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Magnetic%20Resonance%20in%20Medicine&rft.date=2023-12-01&rft.volume=90&rft.issue=6&rft.spage=2306-2320&rft.epage=2306-2320&rft.eissn=1522-2594&rft.issn=1522-2594&rft.au=NEVES%20SILVA,%20Sara&AVILES%20VERDERA,%20Jordina&TOMI-TRICOT,%20Raphael&NEJI,%20Radhouene&UUS,%20Alena&rft.genre=article


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