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dc.rights.licenseopenen_US
dc.contributor.authorOBENAUS, Andre
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorRODRIGUEZ-GRANDE, Beatriz
dc.contributor.authorLEE, Jeong Bin
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorDUBOIS, Christophe
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorFOURNIER, Marie-Line
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCADOR, Martine
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCAILLE, Stéphanie
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorBADAUT, Jerome
dc.date.accessioned2023-11-15T16:45:09Z
dc.date.available2023-11-15T16:45:09Z
dc.date.issued2023-03-01
dc.identifier.issn2051-5960en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184777
dc.description.abstractEnTraumatic brain injury (TBI) has the highest incidence amongst the pediatric population and its mild severity represents the most frequent cases. Moderate and severe injuries as well as repetitive mild TBI result in lasting morbidity. However, whether a single mild TBI sustained during childhood can produce long-lasting modifications within the brain is still debated. We aimed to assess the consequences of a single juvenile mild TBI (jmTBI) at 12 months post-injury in a mouse model. Non-invasive diffusion tensor imaging (DTI) revealed significant microstructural alterations in the hippocampus and the in the substantia innominata/nucleus basalis (SI/NB), structures known to be involved in spatial learning and memory. DTI changes paralled neuronal loss, increased astrocytic AQP4 and microglial activation in the hippocampus. In contrast, decreased astrocytic AQP4 expression and microglia activation were observed in SI/NB. Spatial learning and memory were impaired and correlated with alterations in DTI-derived derived fractional ansiotropy (FA) and axial diffusivity (AD). This study found that a single juvenile mild TBI leads to significant region-specific DTI microstructural alterations, distant from the site of impact, that correlated with cognitive discriminative novel object testing and spatial memory impairments at 12 months after a single concussive injury. Our findings suggest that exposure to jmTBI leads to a chronic abnormality, which confirms the need for continued monitoring of symptoms and the development of long-term treatment strategies to intervene in children with concussions.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAnimals
dc.subject.enMale
dc.subject.enMice
dc.subject.enBrain
dc.subject.enBrain Concussion
dc.subject.enBrain Injuries
dc.subject.enTraumatic
dc.subject.enCognitive Dysfunction
dc.subject.enDiffusion Tensor Imaging
dc.titleA single mild juvenile TBI in male mice leads to regional brain tissue abnormalities at 12 months of age that correlate with cognitive impairment at the middle age
dc.title.alternativeActa Neuropathol Communen_US
dc.typeArticle de revueen_US
dc.subject.halSciences du Vivant [q-bio]en_US
dc.subject.halSciences de l'ingénieur [physics]en_US
dc.identifier.pubmed36859364en_US
bordeaux.journalActa Neuropathologica Communicationsen_US
bordeaux.page32en_US
bordeaux.volume11en_US
bordeaux.hal.laboratoriesCentre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536en_US
bordeaux.hal.laboratoriesInstitut de neurosciences cognitives et intégratives d'Aquitaine (INCIA) - UMR 5287en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04287914
hal.version1
hal.date.transferred2023-11-15T16:45:13Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.title=A%20single%20mild%20juvenile%20TBI%20in%20male%20mice%20leads%20to%20regional%20brain%20tissue%20abnormalities%20at%2012%20months%20of%20age%20that%20correlate%20with%20c&rft.atitle=A%20single%20mild%20juvenile%20TBI%20in%20male%20mice%20leads%20to%20regional%20brain%20tissue%20abnormalities%20at%2012%20months%20of%20age%20that%20correlate%20with%20&rft.jtitle=Acta%20Neuropathologica%20Communications&rft.date=2023-03-01&rft.volume=11&rft.issue=1&rft.spage=32&rft.epage=32&rft.eissn=2051-5960&rft.issn=2051-5960&rft.au=OBENAUS,%20Andre&RODRIGUEZ-GRANDE,%20Beatriz&LEE,%20Jeong%20Bin&DUBOIS,%20Christophe&FOURNIER,%20Marie-Line&rft.genre=article


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