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4-Amino-TEMPO loaded liposomes as sensitive EPR and OMRI probes for the detection of phospholipase A2 activity.

dc.rights.licenseopenen_US
dc.contributor.authorALBERTI, Diego
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorTHIAUDIERE, Eric
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorPARZY, Elodie
dc.contributor.authorELKHANOUFI, Sabrina
dc.contributor.authorRAKHSHAN, Sahar
dc.contributor.authorSTEFANIA, Rachele
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorMASSOT, Philippe
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorMELLET, Philippe
dc.contributor.authorAIME, Silvio
dc.contributor.authorGENINATTI CRICH, Simonetta
dc.date.accessioned2023-11-15T13:56:42Z
dc.date.available2023-11-15T13:56:42Z
dc.date.issued2023-08-22
dc.identifier.issn2045-2322en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184772
dc.description.abstractEnThis work aims at developing a diagnostic method based on Electron Paramagnetic Resonance (EPR) measurements of stable nitroxide radicals released from "EPR silent" liposomes. The liposome destabilisation and consequent radical release is enzymatically triggered by the action of phospholipase A2 (PLA2) present in the biological sample of interest. PLA2 are involved in a broad range of processes, and changes in their activity may be considered as a unique valuable biomarker for early diagnoses. The minimum amount of PLA2 measured "in vitro" was 0.09 U/mL. Moreover, the liposomes were successfully used to perform Overhauser-enhanced Magnetic Resonance Imaging (OMRI) in vitro at 0.2 T. The amount of radicals released by PLA2 driven liposome destabilization was sufficient to generate a well detectable contrast enhancement in the corresponding OMRI image.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enElectron Spin Resonance Spectroscopy
dc.subject.enLiposomes
dc.subject.enCyclic N-Oxides
dc.subject.enMagnetic Resonance Imaging
dc.title.en4-Amino-TEMPO loaded liposomes as sensitive EPR and OMRI probes for the detection of phospholipase A2 activity.
dc.title.alternativeSci Repen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41598-023-40857-4en_US
dc.subject.halSciences de l'ingénieur [physics]en_US
dc.subject.halSciences du Vivant [q-bio]en_US
dc.identifier.pubmed37608036en_US
bordeaux.journalScientific Reportsen_US
bordeaux.page13725en_US
bordeaux.volume13en_US
bordeaux.hal.laboratoriesCentre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDHORIZON EUROPE Framework Programmeen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04287359
hal.version1
hal.date.transferred2023-11-15T13:56:46Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific%20Reports&rft.date=2023-08-22&rft.volume=13&rft.issue=1&rft.spage=13725&rft.epage=13725&rft.eissn=2045-2322&rft.issn=2045-2322&rft.au=ALBERTI,%20Diego&THIAUDIERE,%20Eric&PARZY,%20Elodie&ELKHANOUFI,%20Sabrina&RAKHSHAN,%20Sahar&rft.genre=article


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