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Stricter Blood Pressure Control Is Associated With Lower Left Ventricular Mass in Children After Kidney Transplantation: A Longitudinal Analysis of the 4C-T Study

dc.rights.licenseopenen_US
dc.contributor.authorSUGIANTO, Rizky I
dc.contributor.authorGRABITZ, Carl
dc.contributor.authorBAYAZIT, Aysun
dc.contributor.authorDUZOVA, Ali
dc.contributor.authorTHURN-VALSASSINA, Daniela
dc.contributor.authorMEMARAN, Nima
dc.contributor.authorDOYON, Anke
dc.contributor.authorCANPOLAT, Nur
dc.contributor.authorKAPLAN BULUT, Ipek
dc.contributor.authorAZUKAITIS, Karolis
dc.contributor.authorOBRYCKI, Łukasz
dc.contributor.authorANARAT, Ali
dc.contributor.authorBÜSCHER, Rainer
dc.contributor.authorCALISKAN, Salim
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHARAMBAT, Jerome
IDREF: 110567358
dc.contributor.authorLUGANI, Francesca
dc.contributor.authorOZCAKAR, Zeynep B
dc.contributor.authorPARIPOVIĆ, Dušan
dc.contributor.authorRANCHIN, Bruno
dc.contributor.authorQUERFELD, Uwe
dc.contributor.authorSCHAEFER, Franz
dc.contributor.authorSCHMIDT, Bernhard M W
dc.contributor.authorMELK, Anette
dc.date.accessioned2023-11-14T10:26:31Z
dc.date.available2023-11-14T10:26:31Z
dc.date.issued2023-09-01
dc.identifier.issn1524-4563en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184751
dc.description.abstractEnWe assessed the effect of blood pressure (BP) control on left ventricular mass index (LVMI) and left ventricular hypertrophy (LVH). Ninety-six patients (64 males) ≥9 months post-kidney transplantation from the 4C-T (Cardiovascular Comorbidity in Children with Chronic Kidney Disease and Transplantation) study were analyzed longitudinally (mean follow-up, 2.6±1.3 years). Cumulative systolic blood pressure (SBP)/diastolic BP exposure was calculated as a time-averaged area under the curve and categorized: ≤50th, 50th to ≤75th, 75th to ≤90th, and >90th percentile (pct). We performed adjusted linear and logistic mixed models for LVMI and LVH, respectively. At baseline, LVMI was 49.7±12.7g/m with 64% (n=61) kidney transplantation recipients displaying LVH. Compared with patients with cumulative SBP exposure >90th pct, patients with cumulative SBP of 50th to ≤75th showed a significant LVMI reduction of -5.24g/m (=0.007). A similar tendency was seen for cumulative SBP≤50th (β=-3.70 g/m; =0.067), but patients with cumulative SBP of 75th to ≤90th pct showed no reduction. A post hoc analysis in patients with cumulative SBP≤75th revealed that median SBP exposure was at 57.5th pct. For cumulative diastolic BP, a significant LVMI reduction was seen in all 3 categories ≤90th pct compared with patients >90th pct. Patients with cumulative SBP of ≤50th or 50th to ≤75th pct showed 79% or 83% lower odds of developing LVH, respectively. Patients with cumulative diastolic BP ≤50th showed a tendency of 82% lower odds for LVH (95% CI, 0.03-1.07). Stricter BP control led to regression of LVMI and LVH. Our data suggest a BP target below the 60th pct, which needs to be substantiated in a randomized controlled trial.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enChild
dc.subject.enHumans
dc.subject.enMale
dc.subject.enBlood Pressure
dc.subject.enComorbidity
dc.subject.enHypertension
dc.subject.enHypertrophy
dc.subject.enLeft Ventricular
dc.subject.enKidney Transplantation
dc.subject.enRenal Insufficiency
dc.subject.enChronic
dc.subject.enLongitudinal Studies
dc.title.enStricter Blood Pressure Control Is Associated With Lower Left Ventricular Mass in Children After Kidney Transplantation: A Longitudinal Analysis of the 4C-T Study
dc.title.alternativeHypertensionen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1161/HYPERTENSIONAHA.123.21187en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37462031en_US
bordeaux.journalHypertensionen_US
bordeaux.page1900-1908en_US
bordeaux.volume80en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDEuropean Renal Association-European Dialysis and Transplant Associationen_US
bordeaux.identifier.funderIDRoche Organ Transplant Research Foundationen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04284195
hal.version1
hal.date.transferred2023-11-14T10:26:35Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Hypertension&rft.date=2023-09-01&rft.volume=80&rft.issue=9&rft.spage=1900-1908&rft.epage=1900-1908&rft.eissn=1524-4563&rft.issn=1524-4563&rft.au=SUGIANTO,%20Rizky%20I&GRABITZ,%20Carl&BAYAZIT,%20Aysun&DUZOVA,%20Ali&THURN-VALSASSINA,%20Daniela&rft.genre=article


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