Stricter Blood Pressure Control Is Associated With Lower Left Ventricular Mass in Children After Kidney Transplantation: A Longitudinal Analysis of the 4C-T Study
| dc.rights.license | open | en_US |
| dc.contributor.author | SUGIANTO, Rizky I | |
| dc.contributor.author | GRABITZ, Carl | |
| dc.contributor.author | BAYAZIT, Aysun | |
| dc.contributor.author | DUZOVA, Ali | |
| dc.contributor.author | THURN-VALSASSINA, Daniela | |
| dc.contributor.author | MEMARAN, Nima | |
| dc.contributor.author | DOYON, Anke | |
| dc.contributor.author | CANPOLAT, Nur | |
| dc.contributor.author | KAPLAN BULUT, Ipek | |
| dc.contributor.author | AZUKAITIS, Karolis | |
| dc.contributor.author | OBRYCKI, Łukasz | |
| dc.contributor.author | ANARAT, Ali | |
| dc.contributor.author | BÜSCHER, Rainer | |
| dc.contributor.author | CALISKAN, Salim | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | HARAMBAT, Jerome | |
| dc.contributor.author | LUGANI, Francesca | |
| dc.contributor.author | OZCAKAR, Zeynep B | |
| dc.contributor.author | PARIPOVIĆ, Dušan | |
| dc.contributor.author | RANCHIN, Bruno | |
| dc.contributor.author | QUERFELD, Uwe | |
| dc.contributor.author | SCHAEFER, Franz | |
| dc.contributor.author | SCHMIDT, Bernhard M W | |
| dc.contributor.author | MELK, Anette | |
| dc.date.accessioned | 2023-11-14T10:26:31Z | |
| dc.date.available | 2023-11-14T10:26:31Z | |
| dc.date.issued | 2023-09-01 | |
| dc.identifier.issn | 1524-4563 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/184751 | |
| dc.description.abstractEn | We assessed the effect of blood pressure (BP) control on left ventricular mass index (LVMI) and left ventricular hypertrophy (LVH). Ninety-six patients (64 males) ≥9 months post-kidney transplantation from the 4C-T (Cardiovascular Comorbidity in Children with Chronic Kidney Disease and Transplantation) study were analyzed longitudinally (mean follow-up, 2.6±1.3 years). Cumulative systolic blood pressure (SBP)/diastolic BP exposure was calculated as a time-averaged area under the curve and categorized: ≤50th, 50th to ≤75th, 75th to ≤90th, and >90th percentile (pct). We performed adjusted linear and logistic mixed models for LVMI and LVH, respectively. At baseline, LVMI was 49.7±12.7g/m with 64% (n=61) kidney transplantation recipients displaying LVH. Compared with patients with cumulative SBP exposure >90th pct, patients with cumulative SBP of 50th to ≤75th showed a significant LVMI reduction of -5.24g/m (=0.007). A similar tendency was seen for cumulative SBP≤50th (β=-3.70 g/m; =0.067), but patients with cumulative SBP of 75th to ≤90th pct showed no reduction. A post hoc analysis in patients with cumulative SBP≤75th revealed that median SBP exposure was at 57.5th pct. For cumulative diastolic BP, a significant LVMI reduction was seen in all 3 categories ≤90th pct compared with patients >90th pct. Patients with cumulative SBP of ≤50th or 50th to ≤75th pct showed 79% or 83% lower odds of developing LVH, respectively. Patients with cumulative diastolic BP ≤50th showed a tendency of 82% lower odds for LVH (95% CI, 0.03-1.07). Stricter BP control led to regression of LVMI and LVH. Our data suggest a BP target below the 60th pct, which needs to be substantiated in a randomized controlled trial. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Child | |
| dc.subject.en | Humans | |
| dc.subject.en | Male | |
| dc.subject.en | Blood Pressure | |
| dc.subject.en | Comorbidity | |
| dc.subject.en | Hypertension | |
| dc.subject.en | Hypertrophy | |
| dc.subject.en | Left Ventricular | |
| dc.subject.en | Kidney Transplantation | |
| dc.subject.en | Renal Insufficiency | |
| dc.subject.en | Chronic | |
| dc.subject.en | Longitudinal Studies | |
| dc.title.en | Stricter Blood Pressure Control Is Associated With Lower Left Ventricular Mass in Children After Kidney Transplantation: A Longitudinal Analysis of the 4C-T Study | |
| dc.title.alternative | Hypertension | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1161/HYPERTENSIONAHA.123.21187 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 37462031 | en_US |
| bordeaux.journal | Hypertension | en_US |
| bordeaux.page | 1900-1908 | en_US |
| bordeaux.volume | 80 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 9 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | LEHA | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | European Renal Association-European Dialysis and Transplant Association | en_US |
| bordeaux.identifier.funderID | Roche Organ Transplant Research Foundation | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04284195 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-11-14T10:26:35Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Hypertension&rft.date=2023-09-01&rft.volume=80&rft.issue=9&rft.spage=1900-1908&rft.epage=1900-1908&rft.eissn=1524-4563&rft.issn=1524-4563&rft.au=SUGIANTO,%20Rizky%20I&GRABITZ,%20Carl&BAYAZIT,%20Aysun&DUZOVA,%20Ali&THURN-VALSASSINA,%20Daniela&rft.genre=article |
