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Spirometric patterns in young and middle-aged adults: a 20-year European study

dc.rights.licenseopenen_US
dc.contributor.authorCARSIN, Anne-Elie
dc.contributor.authorGARCIA-AYMERICH, Judith
dc.contributor.authorACCORDINI, Simone
dc.contributor.authorDHARMAGE, Shyamali
dc.contributor.authorLEYNAERT, Bénédicte
dc.contributor.authorDE LAS HERAS, Marti
dc.contributor.authorCASAS, Lidia
dc.contributor.authorCAVIEZEL, Seraina
dc.contributor.authorDEMOLY, Pascal
dc.contributor.authorFORSBERG, Bertil
dc.contributor.authorGISLASON, Thorarinn
dc.contributor.authorCORSICO, Angelo Guido
dc.contributor.authorJANSON, Christer
dc.contributor.authorJOGI, Rain
dc.contributor.authorMARTÍNEZ-MORATALLA, Jesús
dc.contributor.authorNOWAK, Dennis
dc.contributor.authorGÓMEZ, Leopoldo Palacios
dc.contributor.authorPIN, Isabelle
dc.contributor.authorPROBST-HENSCH, Nicole
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRAHERISON-SEMJEN, Chantal
dc.contributor.authorSQUILLACIOTI, Giulia
dc.contributor.authorSVANES, Cecilie
dc.contributor.authorTORÉN, Kjell
dc.contributor.authorURRUTIA, Isabel
dc.contributor.authorHUERTA, Ismael
dc.contributor.authorANTO, Josep Maria
dc.contributor.authorJARVIS, Debbie
dc.contributor.authorGUERRA, Stefano
dc.date.accessioned2023-11-13T14:28:27Z
dc.date.available2023-11-13T14:28:27Z
dc.date.issued2023-09-27
dc.identifier.issn1468-3296en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184742
dc.description.abstractEnUnderstanding the natural history of abnormal spirometric patterns at different stages of life is critical to identify and optimise preventive strategies. We aimed to describe characteristics and risk factors of restrictive and obstructive spirometric patterns occurring before 40 years (young onset) and between 40 and 61 years (mid-adult onset). We used data from the population-based cohort of the European Community Respiratory Health Survey (ECRHS). Prebronchodilator forced expiratory volume in one second (FEV) and forced vital capacity (FVC) were assessed longitudinally at baseline (ECRHS1, 1993-1994) and again 20 years later (ECRHS3, 2010-2013). Spirometry patterns were defined as: restrictive if FEV/FVC≥LLN and FVC<10th percentile, obstructive if FEV/FVC<LLN or normal otherwise. Five spirometry patterns were derived depending on whether participants never developed restrictive/obstructive (normal), developed restrictive/obstructive at baseline (young onset) or at last follow-up (mid-adult onset). The characteristics and risk factors associated with these patterns were described and assessed using multilevel multinomial logistic regression analysis adjusting for age, sex, sample (random or symptomatic) and centre. Among 3502 participants (mean age=30.4 (SD 5.4) at ECRHS1, 50.4 (SD 5.4) at ECRHS3), 2293 (65%) had a normal, 371 (11%) a young restrictive, 301 (9%) a young obstructive, 187 (5%) a mid-adult onset restrictive and 350 (10%) a mid-adult onset obstructive spirometric pattern. Being lean/underweight in childhood and young adult life was associated with the occurrence of the young spirometric restrictive pattern (relative risk ratio (RRR)=1.61 95% CI=1.21 to 2.14, and RRR=2.43 95% CI=1.80 to 3.29; respectively), so were respiratory infections before 5 years (RRR=1.48, 95% CI=1.05 to 2.08). The main determinants for young obstructive, mid-adult restrictive and mid-adult obstructive patterns were asthma, obesity and smoking, respectively. Spirometric patterns with onset in young and mid-adult life were associated with distinct characteristics and risk factors.
dc.language.isoENen_US
dc.subject.enCOPD epidemiology
dc.subject.enClinical Epidemiology
dc.title.enSpirometric patterns in young and middle-aged adults: a 20-year European study
dc.title.alternativeThoraxen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1136/thorax-2022-219696en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37758456en_US
bordeaux.journalThoraxen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstituto de Salud Carlos IIIen_US
bordeaux.identifier.funderIDGeneralitat de Catalunyaen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04282664
hal.version1
hal.date.transferred2023-11-13T14:28:30Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Thorax&amp;rft.date=2023-09-27&amp;rft.eissn=1468-3296&amp;rft.issn=1468-3296&amp;rft.au=CARSIN,%20Anne-Elie&amp;GARCIA-AYMERICH,%20Judith&amp;ACCORDINI,%20Simone&amp;DHARMAGE,%20Shyamali&amp;LEYNAERT,%20B%C3%A9n%C3%A9dicte&amp;rft.genre=article


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