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Trends in Cancer Incidence in Different Antiretroviral Treatment-Eras amongst People with HIV

dc.rights.licenseopenen_US
dc.contributor.authorGREENBERG, Lauren
dc.contributor.authorRYOM, Lene
dc.contributor.authorBAKOWSKA, Elzbieta
dc.contributor.authorWIT, Ferdinand
dc.contributor.authorBUCHER, Heiner C.
dc.contributor.authorBRAUN, Dominique L.
dc.contributor.authorPHILLIPS, Andrew
dc.contributor.authorSABIN, Caroline
dc.contributor.authorD'ARMINIO MONFORTE, Antonella
dc.contributor.authorZANGERLE, Robert
dc.contributor.authorSMITH, Colette
dc.contributor.authorDE WIT, Stephane
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorBONNET, Fabrice
dc.contributor.authorPRADIER, Christian
dc.contributor.authorMUSSINI, Cristina
dc.contributor.authorMUCCINI, Camilla
dc.contributor.authorVEHRESCHILD, Jorg J
dc.contributor.authorHOY, Jennifer
dc.contributor.authorSVEDHEM, Veronica
dc.contributor.authorMIRO, Jose M.
dc.contributor.authorWASMUTH, Jan-Christian
dc.contributor.authorREISS, Peter
dc.contributor.authorLLIBRE, Josep M
dc.contributor.authorCHKHARTISHVILI, Nikoloz
dc.contributor.authorSTEPHAN, Christoph
dc.contributor.authorHATLEBERG, Camilla I.
dc.contributor.authorNEESGAARD, Bastian
dc.contributor.authorPETERS, Lars
dc.contributor.authorJASCHINSKI, Nadine
dc.contributor.authorDEDES, Nikos
dc.contributor.authorKUZOVATOVA, Elena
dc.contributor.authorVAN DER VALK, Marc
dc.contributor.authorMENOZZI, Marianna
dc.contributor.authorLEHMANN, Clara
dc.contributor.authorPETOUMENOS, Kathy
dc.contributor.authorGARGES, Harmony
dc.contributor.authorROONEY, Jim
dc.contributor.authorYOUNG, Lital
dc.contributor.authorLUNDGREN, Jens D.
dc.contributor.authorBANSI-MATHARU, Loveleen
dc.contributor.authorMOCROFT, Amanda
dc.date.accessioned2023-11-13T09:27:40Z
dc.date.available2023-11-13T09:27:40Z
dc.date.issued2023-07-15
dc.identifier.issn2072-6694en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184719
dc.description.abstractEnDespite cancer being a leading comorbidity amongst individuals with HIV, there are limited data assessing cancer trends across different antiretroviral therapy (ART)-eras. We calculated age-standardised cancer incidence rates (IRs) from 2006-2021 in two international cohort collaborations (D:A:D and RESPOND). Poisson regression was used to assess temporal trends, adjusted for potential confounders. Amongst 64,937 individuals (31% ART-naïve at baseline) and 490,376 total person-years of follow-up (PYFU), there were 3763 incident cancers (IR 7.7/1000 PYFU [95% CI 7.4, 7.9]): 950 AIDS-defining cancers (ADCs), 2813 non-ADCs, 1677 infection-related cancers, 1372 smoking-related cancers, and 719 BMI-related cancers (groups were not mutually exclusive). Age-standardised IRs for overall cancer remained fairly constant over time (8.22/1000 PYFU [7.52, 8.97] in 2006-2007, 7.54 [6.59, 8.59] in 2020-2021). The incidence of ADCs (3.23 [2.79, 3.72], 0.99 [0.67, 1.42]) and infection-related cancers (4.83 [4.2, 5.41], 2.43 [1.90, 3.05]) decreased over time, whilst the incidence of non-ADCs (4.99 [4.44, 5.58], 6.55 [5.67, 7.53]), smoking-related cancers (2.38 [2.01, 2.79], 3.25 [2.63-3.96]), and BMI-related cancers (1.07 [0.83, 1.37], 1.88 [1.42, 2.44]) increased. Trends were similar after adjusting for demographics, comorbidities, HIV-related factors, and ART use. These results highlight the need for better prevention strategies to reduce the incidence of NADCs, smoking-, and BMI-related cancers.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enHIV
dc.subject.enNon-AIDS defining cancer
dc.subject.enAIDS defining cancer
dc.subject.enIncidence
dc.subject.enTrends
dc.subject.enSmoking
dc.subject.enInfection
dc.subject.enBody mass index
dc.title.enTrends in Cancer Incidence in Different Antiretroviral Treatment-Eras amongst People with HIV
dc.title.alternativeCancers (Basel)en_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/cancers15143640en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37509301en_US
bordeaux.journalCancersen_US
bordeaux.volume15en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue14en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamGHIGSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDViiV Healthcareen_US
bordeaux.identifier.funderIDGilead Sciencesen_US
bordeaux.identifier.funderIDMerck Sharp and Dohmeen_US
bordeaux.identifier.funderIDInstitut de Recherche pour le Développementen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04281691
hal.version1
hal.date.transferred2023-11-13T09:27:48Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cancers&rft.date=2023-07-15&rft.volume=15&rft.issue=14&rft.eissn=2072-6694&rft.issn=2072-6694&rft.au=GREENBERG,%20Lauren&RYOM,%20Lene&BAKOWSKA,%20Elzbieta&WIT,%20Ferdinand&BUCHER,%20Heiner%20C.&rft.genre=article


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