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dc.rights.licenseopenen_US
dc.contributor.authorBRUZOS, Alicia L.
dc.contributor.authorSANTAMARINA, Martin
dc.contributor.authorGARCIA-SOUTO, Daniel
dc.contributor.authorDIAZ, Seila
dc.contributor.authorROCHA, Sara
dc.contributor.authorVINA-FEAS, Alejandro
dc.contributor.authorZAMORA, Jorge
dc.contributor.authorLEE, Yunah
dc.contributor.authorQUAIL, Michael A.
dc.contributor.authorOTERO, Iago
dc.contributor.authorPEQUENO-VALTIERRA, Ana
dc.contributor.authorTEMES, Javier
dc.contributor.authorRODRIGUEZ-CASTRO, Jorge
dc.contributor.authorARAMBURU, Leyre
dc.contributor.authorVIDAL-CAPON, Andre
dc.contributor.authorVILLANUEVA, Antonio
dc.contributor.authorCOSTAS, Damian
dc.contributor.authorRODRIGUEZ, Rosana
dc.contributor.authorPRIETO, Tamara
dc.contributor.authorTOMAS, Laura
dc.contributor.authorALVARINO, Pilar
dc.contributor.authorALONSO, Juana
dc.contributor.authorCAO, Asuncion
dc.contributor.authorIGLESIAS, David
dc.contributor.authorCARBALLAL, Maria J.
dc.contributor.authorAMARAL, Ana M.
dc.contributor.authorBALSEIRO, Pablo
dc.contributor.authorCALADO, Ricardo
dc.contributor.authorEL KHALFI, Bouchra
dc.contributor.authorIZAGIRRE, Urtzi
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorDE MONTAUDOUIN, Xavier
dc.contributor.authorPADE, Nicolas G.
dc.contributor.authorPROBERT, Ian
dc.contributor.authorRICARDO, Fernando
dc.contributor.authorRUIZ, Pamela
dc.contributor.authorSKAZINA, Maria
dc.contributor.authorSMOLARZ, Katarzyna
dc.contributor.authorPASANTES, Juan J.
dc.contributor.authorVILLALBA, Antonio
dc.contributor.authorNING, Zemin
dc.contributor.authorJU, Young Seok
dc.contributor.authorPOSADA, David
dc.contributor.authorDEMEULEMEESTER, Jonas
dc.contributor.authorBAEZ-ORTEGA, Adrian
dc.contributor.authorTUBIO, Jose M. C.
dc.date.accessioned2023-11-08T10:34:44Z
dc.date.available2023-11-08T10:34:44Z
dc.date.issued2023-10-02
dc.identifier.urioai:crossref.org:10.1038/s43018-023-00641-9
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184679
dc.description.abstractEnTransmissible cancers are malignant cell lineages that spread clonally between individuals. Several such cancers, termed bivalve transmissible neoplasia (BTN), induce leukemia-like disease in marine bivalves. This is the case of BTN lineages affecting the common cockle, Cerastoderma edule, which inhabits the Atlantic coasts of Europe and northwest Africa. To investigate the evolution of cockle BTN, we collected 6,854 cockles, diagnosed 390 BTN tumors, generated a reference genome and assessed genomic variation across 61 tumors. Our analyses confirmed the existence of two BTN lineages with hemocytic origins. Mitochondrial variation revealed mitochondrial capture and host co-infection events. Mutational analyses identified lineage-specific signatures, one of which likely reflects DNA alkylation. Cytogenetic and copy number analyses uncovered pervasive genomic instability, with whole-genome duplication, oncogene amplification and alkylation-repair suppression as likely drivers. Satellite DNA distributions suggested ancient clonal origins. Our study illuminates long-term cancer evolution under the sea and reveals tolerance of extreme instability in neoplastic genomes.
dc.language.isoENen_US
dc.sourcecrossref
dc.title.enSomatic evolution of marine transmissible leukemias in the common cockle, Cerastoderma edule
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s43018-023-00641-9en_US
dc.subject.halSciences de l'environnementen_US
bordeaux.journalNature Canceren_US
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamECOBIOCen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.identifierhal-04274962
hal.version1
hal.date.transferred2023-11-08T10:34:51Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Cancer&rft.date=2023-10-02&rft.au=BRUZOS,%20Alicia%20L.&SANTAMARINA,%20Martin&GARCIA-SOUTO,%20Daniel&DIAZ,%20Seila&ROCHA,%20Sara&rft.genre=article


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