Identification of early gene expression profiles associated with long-lasting antibody responses to the Ebola vaccine Ad26.ZEBOV/MVA-BN-Filo
| dc.rights.license | open | en_US |
| dc.contributor.author | BLENGIO, Fabiola | |
| dc.contributor.author | HOCINI, Hakim | |
| hal.structure.identifier | Statistics In System biology and Translational Medicine [SISTM] | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | RICHERT, Laura | |
| dc.contributor.author | LEFEBVRE, Cécile | |
| hal.structure.identifier | Statistics In System biology and Translational Medicine [SISTM] | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DURAND, Melany | |
| hal.structure.identifier | Statistics In System biology and Translational Medicine [SISTM] | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | HEJBLUM, Boris
ORCID: 0000-0003-0646-452X IDREF: 189970316 | |
| dc.contributor.author | TISSERAND, Pascaline | |
| dc.contributor.author | MCLEAN, Chelsea | |
| dc.contributor.author | LUHN, Kerstin | |
| hal.structure.identifier | Statistics In System biology and Translational Medicine [SISTM] | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | THIEBAUT, Rodolphe | |
| dc.contributor.author | LEVY, Yves | |
| dc.date.accessioned | 2023-11-07T14:41:55Z | |
| dc.date.available | 2023-11-07T14:41:55Z | |
| dc.date.issued | 2023-09-26 | |
| dc.identifier.issn | 2211-1247 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/184670 | |
| dc.description.abstractEn | Ebola virus disease is a severe hemorrhagic fever with a high fatality rate. We investigate transcriptome profiles at 3 h, 1 day, and 7 days after vaccination with Ad26.ZEBOV and MVA-BN-Filo. 3 h after Ad26.ZEBOV injection, we observe an increase in genes related to antigen presentation, sensing, and T and B cell receptors. The highest response occurs 1 day after Ad26.ZEBOV injection, with an increase of the gene expression of interferon-induced antiviral molecules, monocyte activation, and sensing receptors. This response is regulated by the HESX1, ATF3, ANKRD22, and ETV7 transcription factors. A plasma cell signature is observed on day 7 post-Ad26.ZEBOV vaccination, with an increase of CD138, MZB1, CD38, CD79A, and immunoglobulin genes. We have identified early expressed genes correlated with the magnitude of the antibody response 21 days after the MVA-BN-Filo and 364 days after Ad26.ZEBOV vaccinations. Our results provide early gene signatures that correlate with vaccine-induced Ebola virus glycoprotein-specific antibodies. | |
| dc.description.sponsorship | Initiative for the creation of a Vaccine Research Institute - ANR-10-LABX-0077 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject.en | Humans | |
| dc.subject.en | Ebola Vaccines | |
| dc.subject.en | Hemorrhagic Fever | |
| dc.subject.en | Ebola | |
| dc.subject.en | Antibody Formation | |
| dc.subject.en | Ebolavirus | |
| dc.subject.en | Transcriptome | |
| dc.subject.en | Vaccination | |
| dc.subject.en | Antibodies | |
| dc.subject.en | Viral | |
| dc.subject.en | Vaccinia virus | |
| dc.title.en | Identification of early gene expression profiles associated with long-lasting antibody responses to the Ebola vaccine Ad26.ZEBOV/MVA-BN-Filo | |
| dc.title.alternative | Cell Rep | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.celrep.2023.113101 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 37691146 | en_US |
| dc.description.sponsorshipEurope | Horizon 2020 research and innovation programme | en_US |
| bordeaux.journal | Cell Reports | en_US |
| bordeaux.page | 113101 | en_US |
| bordeaux.volume | 42 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 9 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | INRIA | en_US |
| bordeaux.team | SISTM | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Innovative Medicines Initiative | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04273901 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-11-07T14:41:58Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cell%20Reports&rft.date=2023-09-26&rft.volume=42&rft.issue=9&rft.spage=113101&rft.epage=113101&rft.eissn=2211-1247&rft.issn=2211-1247&rft.au=BLENGIO,%20Fabiola&HOCINI,%20Hakim&RICHERT,%20Laura&LEFEBVRE,%20C%C3%A9cile&DURAND,%20Melany&rft.genre=article |
