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Polygenic risk of major depressive disorder as a risk factor for venous thromboembolism.

dc.rights.licenseopenen_US
dc.contributor.authorWARD, Joey
dc.contributor.authorLE, Ngoc-Quynh
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSURYAKANT, Suryakant
dc.contributor.authorBRODY, Jennifer A
dc.contributor.authorAMOUYEL, Philippe
dc.contributor.authorBOLAND, Anne
dc.contributor.authorBOWN, Rosemary
dc.contributor.authorCULLEN, Breda
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorDELEUZE, Jean-François
dc.contributor.authorEMMERICH, Joseph
dc.contributor.authorGRAHAM, Nicholas
dc.contributor.authorGERMAIN, Marine
dc.contributor.authorANDERSON, Jana J
dc.contributor.authorPELL, Jill P
dc.contributor.authorLYALL, Donald M
dc.contributor.authorLYALL, Laura M
dc.contributor.authorSMITH, Daniel J
dc.contributor.authorWIGGINS, Kerri L
dc.contributor.authorSORIA, José Manuel
dc.contributor.authorSOUTO, Juan Carlos
dc.contributor.authorMORANGE, Pierre-Emmanuel
dc.contributor.authorSMITH, Nicholas L
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTREGOUET, David-Alexandre
dc.contributor.authorSABATER-LLEAL, Maria
dc.contributor.authorSTRAWBRIDGE, Rona J
dc.date.accessioned2023-11-07T14:15:54Z
dc.date.available2023-11-07T14:15:54Z
dc.date.issued2023-09-14
dc.identifier.issn2473-9537en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184664
dc.description.abstractEnMajor depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ) are associated with an increased risk of cardiovascular diseases, including venous thromboembolism (VTE). The reasons for this are complex and include obesity, smoking, and use of hormones and psychotropic medications. Genetic studies have increasingly provided evidence of the shared genetic risk of psychiatric and cardiometabolic illnesses. This study aimed to determine whether a genetic predisposition to MDD, BD, or SCZ is associated with an increased risk of VTE. Genetic correlations using the largest genome-wide genetic meta-analyses summary statistics for MDD, BD, and SCZ (Psychiatric Genetics Consortium) and a recent genome-wide genetic meta-analysis of VTE (INVENT Consortium) demonstrated a positive association between VTE and MDD but not BD or SCZ. The same summary statistics were used to construct polygenic risk scores for MDD, BD, and SCZ in UK Biobank participants of self-reported White British ancestry. These were assessed for impact on self-reported VTE risk (10 786 cases, 285 124 controls), using logistic regression, in sex-specific and sex-combined analyses. We identified significant positive associations between polygenic risk for MDD and the risk of VTE in men, women, and sex-combined analyses, independent of the known risk factors. Secondary analyses demonstrated that this association was not driven by those with lifetime experience of mental illness. Meta-analyses of individual data from 6 additional independent cohorts replicated the sex-combined association. This report provides evidence for shared biological mechanisms leading to MDD and VTE and suggests that, in the absence of genetic data, a family history of MDD might be considered when assessing the risk of VTE.
dc.description.sponsorshipMedical Genomics - ANR-10-LABX-0013en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enMale
dc.subject.enHumans
dc.subject.enFemale
dc.subject.enDepressive Disorder
dc.subject.enMajor
dc.subject.enVenous Thromboembolism
dc.subject.enBipolar Disorder
dc.subject.enSchizophrenia
dc.subject.enRisk Factors
dc.title.enPolygenic risk of major depressive disorder as a risk factor for venous thromboembolism.
dc.title.alternativeBlood Adven_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1182/bloodadvances.2023010562en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37399490en_US
bordeaux.journalBlood Advancesen_US
bordeaux.page5341-5350en_US
bordeaux.volume7en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue18en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamELEANORen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDBritish Heart Foundationen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDFondation de Franceen_US
bordeaux.identifier.funderIDFondation Leducqen_US
bordeaux.import.sourcepubmed
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Blood%20Advances&rft.date=2023-09-14&rft.volume=7&rft.issue=18&rft.spage=5341-5350&rft.epage=5341-5350&rft.eissn=2473-9537&rft.issn=2473-9537&rft.au=WARD,%20Joey&LE,%20Ngoc-Quynh&SURYAKANT,%20Suryakant&BRODY,%20Jennifer%20A&AMOUYEL,%20Philippe&rft.genre=article


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