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Association between pre-diagnosis geriatric syndromes and overall survival in older adults with cancer (the INCAPAC study)

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGALVIN, Angeline
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFRASCA, Matthieu
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSOUBEYRAN, Pierre
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRONDEAU, Virginie
ORCID: 0000-0001-7109-4831
IDREF: 16662988X
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELVA, Fleur
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPERES, Karine
ORCID: 0000-0002-0720-0684
IDREF: 080634001
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOUREAU, Gaelle
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMATHOULIN-PELISSIER, Simone
dc.date.accessioned2023-10-17T10:08:11Z
dc.date.available2023-10-17T10:08:11Z
dc.date.issued2023-07-01
dc.identifier.issn1879-4076en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184463
dc.description.abstractEnSeveral population-based studies have reported disparities in overall survival (OS) among older patients with cancer. However, geriatric syndromes, known to be associated with OS in the geriatric population, were rarely studied. Thus, our aim was to identify the determinants of OS among French older adults with cancer, including geriatric syndromes before cancer diagnosis. Using cancer registries, we identified older subjects (≥65 years) with cancer in three French prospective cohort studies on aging from the Gironde department. Survival time was calculated from the date of diagnosis to the date of all-cause death or to the date of last follow-up, whichever came first. Demographic and socioeconomic characteristics, smoking status, self-rated health, cancer-related factors (stage at diagnosis, treatment), as well as geriatric syndromes (polypharmacy, activity limitation, depressive symptomatology, and cognitive impairment or dementia) were studied. Analyses were performed using Cox proportional hazard models for the whole population, then by age group (65-84 and 85+). Among the 607 subjects included in the study, the median age at cancer diagnosis was 84 years. Smoking habits, activity limitations, cognitive impairment or dementia, advanced cancer stage and absence of treatment were significantly associated with lower OS in the analysis including the whole population. Women presented higher OS. Factors associated with OS differed by age group. Polypharmacy was inversely associated with OS in older adults aged 65-84 and 85 + . Our findings support that geriatric assessment is needed to identify patients at higher risk of death and that an evaluation of activity limitation in older adults is essential. Improving early detection could enable interventions to address factors (activity limitations, cognitive impairment) associated with OS, potentially reducing disparities and lead to earlier palliative care.
dc.language.isoENen_US
dc.subject.enHumans
dc.subject.enAged
dc.subject.enFemale
dc.subject.enAged
dc.subject.en80 and over
dc.subject.enProspective Studies
dc.subject.enSyndrome
dc.subject.enAging
dc.subject.enNeoplasms
dc.subject.enGeriatric Assessment
dc.subject.enDementia
dc.title.enAssociation between pre-diagnosis geriatric syndromes and overall survival in older adults with cancer (the INCAPAC study)
dc.title.alternativeJ Geriatr Oncolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jgo.2023.101539en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37320933en_US
bordeaux.journalJournal of Geriatric Oncologyen_US
bordeaux.page101539en_US
bordeaux.volume14en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue6en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENEen_US
bordeaux.teamBIOSTATen_US
bordeaux.teamACTIVEen_US
bordeaux.teamLEHAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National Du Canceren_US
bordeaux.import.sourcepubmed
hal.identifierhal-04245889
hal.version1
hal.date.transferred2023-10-17T10:08:13Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Geriatric%20Oncology&rft.date=2023-07-01&rft.volume=14&rft.issue=6&rft.spage=101539&rft.epage=101539&rft.eissn=1879-4076&rft.issn=1879-4076&rft.au=GALVIN,%20Angeline&FRASCA,%20Matthieu&SOUBEYRAN,%20Pierre&RONDEAU,%20Virginie&DELVA,%20Fleur&rft.genre=article


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