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Epigenome-Wide Associations of Placental DNA Methylation and Behavioral and Emotional Difficulties in Children at 3 Years of Age
| dc.rights.license | open | en_US |
| dc.contributor.author | NAKAMURA, Aurélie | |
| dc.contributor.author | BROSÉUS, Lucile | |
| dc.contributor.author | TOST, Jörg | |
| dc.contributor.author | VAIMAN, Daniel | |
| dc.contributor.author | MARTINS, Silvia | |
| dc.contributor.author | KEYES, Katherine | |
| dc.contributor.author | BONELLO, Kim | |
| dc.contributor.author | FEKOM, Mathilde | |
| dc.contributor.author | STRANDBERG-LARSEN, Katrine | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SUTTER-DALLAY, Anne-Laure | |
| dc.contributor.author | HEUDE, Barbara | |
| dc.contributor.author | MELCHIOR, Maria | |
| dc.contributor.author | LEPEULE, Johanna | |
| dc.date.accessioned | 2023-10-17T09:44:32Z | |
| dc.date.available | 2023-10-17T09:44:32Z | |
| dc.date.issued | 2023-07-21 | |
| dc.identifier.issn | 1422-0067 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/184455 | |
| dc.description.abstractEn | The placenta is a key organ for fetal and brain development. Its epigenome can be regarded as a biochemical record of the prenatal environment and a potential mechanism of its association with the future health of the fetus. We investigated associations between placental DNA methylation levels and child behavioral and emotional difficulties, assessed at 3 years of age using the Strengths and Difficulties Questionnaire (SDQ) in 441 mother-child dyads from the EDEN cohort. Hypothesis-driven and exploratory analyses (on differentially methylated probes (EWAS) and regions (DMR)) were adjusted for confounders, technical factors, and cell composition estimates, corrected for multiple comparisons, and stratified by child sex. Hypothesis-driven analyses showed an association of cg26703534 () with emotional symptoms, and exploratory analyses identified two probes, cg09126090 (intergenic region) and cg10305789 (), as negatively associated with peer relationship problems, as well as 33 DMRs, mostly positively associated with at least one of the SDQ subscales. Among girls, most associations were seen with emotional difficulties, whereas in boys, DMRs were as much associated with emotional than behavioral difficulties. This study provides the first evidence of associations between placental DNA methylation and child behavioral and emotional difficulties. Our results suggest sex-specific associations and might provide new insights into the mechanisms of neurodevelopment. | |
| dc.description.sponsorship | Exposition prénatale au tabac et à la pollution atmosphérique et effets sur la santé respiratoire et le neurodévelopment de l'enfant: rôle de la méthylation placentaire - ANR-18-CE36-0005 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Male | |
| dc.subject.en | Humans | |
| dc.subject.en | Female | |
| dc.subject.en | Pregnancy | |
| dc.subject.en | DNA Methylation | |
| dc.subject.en | Placenta | |
| dc.subject.en | Epigenome | |
| dc.subject.en | Emotions | |
| dc.subject.en | Fetus | |
| dc.title | Epigenome-Wide Associations of Placental DNA Methylation and Behavioral and Emotional Difficulties in Children at 3 Years of Age | |
| dc.title.alternative | Int J Mol Sci | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3390/ijms241411772 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 37511531 | en_US |
| dc.description.sponsorshipEurope | Horizon 2020 research and innovation programme | en_US |
| bordeaux.journal | International Journal of Molecular Sciences | en_US |
| bordeaux.page | 11772 | en_US |
| bordeaux.volume | 24 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 14 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | HEALTHY | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Institut pour la Recherche en Santé Publique | en_US |
| bordeaux.identifier.funderID | Institut National Du Cancer | en_US |
| bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Ministère de la Santé | en_US |
| bordeaux.identifier.funderID | Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail | en_US |
| bordeaux.identifier.funderID | Mutuelle Générale de l'Education Nationale | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04245800 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-10-17T09:44:36Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
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