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Epigenome-Wide Associations of Placental DNA Methylation and Behavioral and Emotional Difficulties in Children at 3 Years of Age

dc.rights.licenseopenen_US
dc.contributor.authorNAKAMURA, Aurélie
dc.contributor.authorBROSÉUS, Lucile
dc.contributor.authorTOST, Jörg
dc.contributor.authorVAIMAN, Daniel
dc.contributor.authorMARTINS, Silvia
dc.contributor.authorKEYES, Katherine
dc.contributor.authorBONELLO, Kim
dc.contributor.authorFEKOM, Mathilde
dc.contributor.authorSTRANDBERG-LARSEN, Katrine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSUTTER-DALLAY, Anne-Laure
dc.contributor.authorHEUDE, Barbara
dc.contributor.authorMELCHIOR, Maria
dc.contributor.authorLEPEULE, Johanna
dc.date.accessioned2023-10-17T09:44:32Z
dc.date.available2023-10-17T09:44:32Z
dc.date.issued2023-07-21
dc.identifier.issn1422-0067en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184455
dc.description.abstractEnThe placenta is a key organ for fetal and brain development. Its epigenome can be regarded as a biochemical record of the prenatal environment and a potential mechanism of its association with the future health of the fetus. We investigated associations between placental DNA methylation levels and child behavioral and emotional difficulties, assessed at 3 years of age using the Strengths and Difficulties Questionnaire (SDQ) in 441 mother-child dyads from the EDEN cohort. Hypothesis-driven and exploratory analyses (on differentially methylated probes (EWAS) and regions (DMR)) were adjusted for confounders, technical factors, and cell composition estimates, corrected for multiple comparisons, and stratified by child sex. Hypothesis-driven analyses showed an association of cg26703534 () with emotional symptoms, and exploratory analyses identified two probes, cg09126090 (intergenic region) and cg10305789 (), as negatively associated with peer relationship problems, as well as 33 DMRs, mostly positively associated with at least one of the SDQ subscales. Among girls, most associations were seen with emotional difficulties, whereas in boys, DMRs were as much associated with emotional than behavioral difficulties. This study provides the first evidence of associations between placental DNA methylation and child behavioral and emotional difficulties. Our results suggest sex-specific associations and might provide new insights into the mechanisms of neurodevelopment.
dc.description.sponsorshipExposition prénatale au tabac et à la pollution atmosphérique et effets sur la santé respiratoire et le neurodévelopment de l'enfant: rôle de la méthylation placentaireen_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enMale
dc.subject.enHumans
dc.subject.enFemale
dc.subject.enPregnancy
dc.subject.enDNA Methylation
dc.subject.enPlacenta
dc.subject.enEpigenome
dc.subject.enEmotions
dc.subject.enFetus
dc.titleEpigenome-Wide Associations of Placental DNA Methylation and Behavioral and Emotional Difficulties in Children at 3 Years of Age
dc.title.alternativeInt J Mol Scien_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/ijms241411772en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37511531en_US
dc.description.sponsorshipEuropeHorizon 2020 research and innovation programmeen_US
bordeaux.journalInternational Journal of Molecular Sciencesen_US
bordeaux.page11772en_US
bordeaux.volume24en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue14en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamHEALTHYen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut pour la Recherche en Santé Publiqueen_US
bordeaux.identifier.funderIDInstitut National Du Canceren_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDMinistère de la Santéen_US
bordeaux.identifier.funderIDAgence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travailen_US
bordeaux.identifier.funderIDMutuelle Générale de l'Education Nationaleen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04245800
hal.version1
hal.date.transferred2023-10-17T09:44:36Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
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